Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study
COVID-19 vaccines are highly protective against severe disease; however, vaccine breakthrough infections resulting in hospitalization may still occur in a small percentage of vaccinated individuals. We investigated whether the clinical and microbiological features and outcomes were different between...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/5/733 |
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| author | Serap Şimşek Yavuz Gülşah Tunçer Özlem Altuntaş-Aydın Mehtap Aydın Filiz Pehlivanoğlu Yeşim Tok Sevim Mese Alper Gündüz Ceyda Geyiktepe Güçlü İklima Özdoğan Börçe Hemiş-Aydın Pınar Soğuksu Aysun Benli Seniha Başaran Kenan Midilli Haluk Eraksoy |
| author_facet | Serap Şimşek Yavuz Gülşah Tunçer Özlem Altuntaş-Aydın Mehtap Aydın Filiz Pehlivanoğlu Yeşim Tok Sevim Mese Alper Gündüz Ceyda Geyiktepe Güçlü İklima Özdoğan Börçe Hemiş-Aydın Pınar Soğuksu Aysun Benli Seniha Başaran Kenan Midilli Haluk Eraksoy |
| author_sort | Serap Şimşek Yavuz |
| collection | DOAJ |
| description | COVID-19 vaccines are highly protective against severe disease; however, vaccine breakthrough infections resulting in hospitalization may still occur in a small percentage of vaccinated individuals. We investigated whether the clinical and microbiological features and outcomes were different between hospitalized COVID-19 patients who were either fully vaccinated with Coronovac or not. All hospitalized COVID-19 patients who had at least one dose of Coronavac were included in the study. The oldest unvaccinated patients with comorbidities, who were hospitalized during the same period, were chosen as controls. All epidemiologic, clinical and laboratory data of the patients were recorded and compared between the fully vaccinated and unvaccinated individuals. There were 69 and 217 patients who had been either fully vaccinated with Coronavac or not, respectively. All breakthrough infections occurred in the first 3 months of vaccination. Fully vaccinated patients were older and had more comorbidities than unvaccinated patients. There were minor differences between the groups in symptoms, physical and laboratory findings, anti-spike IgG positivity rate and level, the severity of COVID-19, complications, and clinical improvement rate. The mortality rate of fully vaccinated patients was higher than the mortality rate in unvaccinated patients in univariate analysis, which was attributed to the fact that vaccinated patients were older and had more comorbidities. The severity and clinical outcomes of hospitalized patients with breakthrough COVID-19 after Coronavac vaccination were similar to those of unvaccinated patients. Our findings suggest that the immune response elicited by Coronovac could be insufficient to prevent COVID-19-related severe disease and death within 3 months of vaccination among elderly people with comorbidities. |
| first_indexed | 2024-03-10T01:39:21Z |
| format | Article |
| id | doaj.art-5b1b5d317b154d2da8a19aa6940ead49 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T01:39:21Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-5b1b5d317b154d2da8a19aa6940ead492023-11-23T13:26:20ZengMDPI AGVaccines2076-393X2022-05-0110573310.3390/vaccines10050733Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional StudySerap Şimşek Yavuz0Gülşah Tunçer1Özlem Altuntaş-Aydın2Mehtap Aydın3Filiz Pehlivanoğlu4Yeşim Tok5Sevim Mese6Alper Gündüz7Ceyda Geyiktepe Güçlü8İklima Özdoğan9Börçe Hemiş-Aydın10Pınar Soğuksu11Aysun Benli12Seniha Başaran13Kenan Midilli14Haluk Eraksoy15Department of Infectious Disease and Clinical Microbiology, İstanbul Faculty of Medicine, İstanbul University, İstanbul 34093, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Haseki Training and Research Hospital, İstanbul 34093, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Çam and Sakura City Hospital, İstanbul 34093, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Ümraniye Training and Research Hospital, İstanbul 34093, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Haseki Training and Research Hospital, İstanbul 34093, TurkeyDepartment of Medical Microbiology, Cerrahpaşa Faculty of Medicine, Division of Virology, Istanbul Cerrahpaşa University, İstanbul 34093, TurkeyDepartment of Medical Microbiology, Istanbul Faculty of Medicine, Division of Virology and Fundamental Immunology, Istanbul University, İstanbul 34093, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Çam and Sakura City Hospital, İstanbul 34093, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Haseki Training and Research Hospital, İstanbul 34093, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Ümraniye Training and Research Hospital, İstanbul 34093, TurkeyDepartment of Infectious Disease and Clinical Microbiology, İstanbul Faculty of Medicine, İstanbul University, İstanbul 34093, TurkeyDepartment of Medical Microbiology, Istanbul Faculty of Medicine, Division of Virology and Fundamental Immunology, Istanbul University, İstanbul 34093, TurkeyDepartment of Infectious Disease and Clinical Microbiology, İstanbul Faculty of Medicine, İstanbul University, İstanbul 34093, TurkeyDepartment of Infectious Disease and Clinical Microbiology, İstanbul Faculty of Medicine, İstanbul University, İstanbul 34093, TurkeyDepartment of Medical Microbiology, Cerrahpaşa Faculty of Medicine, Division of Virology, Istanbul Cerrahpaşa University, İstanbul 34093, TurkeyDepartment of Infectious Disease and Clinical Microbiology, İstanbul Faculty of Medicine, İstanbul University, İstanbul 34093, TurkeyCOVID-19 vaccines are highly protective against severe disease; however, vaccine breakthrough infections resulting in hospitalization may still occur in a small percentage of vaccinated individuals. We investigated whether the clinical and microbiological features and outcomes were different between hospitalized COVID-19 patients who were either fully vaccinated with Coronovac or not. All hospitalized COVID-19 patients who had at least one dose of Coronavac were included in the study. The oldest unvaccinated patients with comorbidities, who were hospitalized during the same period, were chosen as controls. All epidemiologic, clinical and laboratory data of the patients were recorded and compared between the fully vaccinated and unvaccinated individuals. There were 69 and 217 patients who had been either fully vaccinated with Coronavac or not, respectively. All breakthrough infections occurred in the first 3 months of vaccination. Fully vaccinated patients were older and had more comorbidities than unvaccinated patients. There were minor differences between the groups in symptoms, physical and laboratory findings, anti-spike IgG positivity rate and level, the severity of COVID-19, complications, and clinical improvement rate. The mortality rate of fully vaccinated patients was higher than the mortality rate in unvaccinated patients in univariate analysis, which was attributed to the fact that vaccinated patients were older and had more comorbidities. The severity and clinical outcomes of hospitalized patients with breakthrough COVID-19 after Coronavac vaccination were similar to those of unvaccinated patients. Our findings suggest that the immune response elicited by Coronovac could be insufficient to prevent COVID-19-related severe disease and death within 3 months of vaccination among elderly people with comorbidities.https://www.mdpi.com/2076-393X/10/5/733COVID-19breakthrough COVID-19inactivated SARS-CoV-2 vaccineCoronavac |
| spellingShingle | Serap Şimşek Yavuz Gülşah Tunçer Özlem Altuntaş-Aydın Mehtap Aydın Filiz Pehlivanoğlu Yeşim Tok Sevim Mese Alper Gündüz Ceyda Geyiktepe Güçlü İklima Özdoğan Börçe Hemiş-Aydın Pınar Soğuksu Aysun Benli Seniha Başaran Kenan Midilli Haluk Eraksoy Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study Vaccines COVID-19 breakthrough COVID-19 inactivated SARS-CoV-2 vaccine Coronavac |
| title | Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study |
| title_full | Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study |
| title_fullStr | Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study |
| title_full_unstemmed | Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study |
| title_short | Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study |
| title_sort | comparison of the clinical and laboratory findings and outcomes of hospitalized covid 19 patients who were either fully vaccinated with coronavac or not an analytical cross sectional study |
| topic | COVID-19 breakthrough COVID-19 inactivated SARS-CoV-2 vaccine Coronavac |
| url | https://www.mdpi.com/2076-393X/10/5/733 |
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