CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2007-01-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001 |
| _version_ | 1828396573582688256 |
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| author | Renata dos Santos Coura Christiane de Fátima Silva Marques Rosalina J. Koifman Sergio Koifman Pedro Hernan Cabello Ana Hatagima |
| author_facet | Renata dos Santos Coura Christiane de Fátima Silva Marques Rosalina J. Koifman Sergio Koifman Pedro Hernan Cabello Ana Hatagima |
| author_sort | Renata dos Santos Coura |
| collection | DOAJ |
| description | The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11) was higher than in Caucasians (0.05), which may be a result of the Amerindian genetic component, that presents the highest frequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups. |
| first_indexed | 2024-12-10T08:32:27Z |
| format | Article |
| id | doaj.art-5b1b9d38d3b24ca18e335ff9d69f59db |
| institution | Directory Open Access Journal |
| issn | 1415-4757 1678-4685 |
| language | English |
| last_indexed | 2024-12-10T08:32:27Z |
| publishDate | 2007-01-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-5b1b9d38d3b24ca18e335ff9d69f59db2022-12-22T01:56:03ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46852007-01-013011510.1590/S1415-47572007000100001CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian populationRenata dos Santos CouraChristiane de Fátima Silva MarquesRosalina J. KoifmanSergio KoifmanPedro Hernan CabelloAna HatagimaThe enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11) was higher than in Caucasians (0.05), which may be a result of the Amerindian genetic component, that presents the highest frequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001cytochromes P450CYP1A1CYP2E1Brazil |
| spellingShingle | Renata dos Santos Coura Christiane de Fátima Silva Marques Rosalina J. Koifman Sergio Koifman Pedro Hernan Cabello Ana Hatagima CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population Genetics and Molecular Biology cytochromes P450 CYP1A1 CYP2E1 Brazil |
| title | CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population |
| title_full | CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population |
| title_fullStr | CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population |
| title_full_unstemmed | CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population |
| title_short | CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population |
| title_sort | cyp1a1 and cyp2e1 polymorphism frequencies in a large brazilian population |
| topic | cytochromes P450 CYP1A1 CYP2E1 Brazil |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001 |
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