Intracranial Arterial Calcifications: Potential Biomarkers of Stroke Risk and Outcome
Intracranial artery calcifications (IAC), a common and easily identifiable finding on computed tomorgraphy angiography (CTA), has gained recognition as a possible risk factor for ischemic stroke. While atherosclerosis of intracranial arteries is believed to be a mechanism that commonly contributes t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.900579/full |
| _version_ | 1811188144943398912 |
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| author | Gianna M. Fote Sophia Raefsky Kelton Mock Amit Chaudhari Mohammad Shafie Wengui Yu |
| author_facet | Gianna M. Fote Sophia Raefsky Kelton Mock Amit Chaudhari Mohammad Shafie Wengui Yu |
| author_sort | Gianna M. Fote |
| collection | DOAJ |
| description | Intracranial artery calcifications (IAC), a common and easily identifiable finding on computed tomorgraphy angiography (CTA), has gained recognition as a possible risk factor for ischemic stroke. While atherosclerosis of intracranial arteries is believed to be a mechanism that commonly contributes to ischemic stroke, and coronary artery calcification is well-established as a predictor of both myocardial infarction (MI) and ischemic stroke risk, IAC is not currently used as a prognostic tool for stroke risk or recurrence. This review examines the pathophysiology and prevalence of IAC, and current evidence suggesting that IAC may be a useful tool for prediction of stroke incidence, recurrence, and response to acute ischemic stroke therapy. |
| first_indexed | 2024-04-11T14:15:48Z |
| format | Article |
| id | doaj.art-5b1c8903a2ac48c38a0ffa7b0eba4e84 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T14:15:48Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-5b1c8903a2ac48c38a0ffa7b0eba4e842022-12-22T04:19:33ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-09-011310.3389/fneur.2022.900579900579Intracranial Arterial Calcifications: Potential Biomarkers of Stroke Risk and OutcomeGianna M. Fote0Sophia Raefsky1Kelton Mock2Amit Chaudhari3Mohammad Shafie4Wengui Yu5School of Medicine, University of California, Irvine, Irvine, CA, United StatesDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, United StatesSchool of Medicine, University of California, Irvine, Irvine, CA, United StatesDepartment of Neurology, University of California, Irvine, Irvine, CA, United StatesDepartment of Neurology, University of California, Irvine, Irvine, CA, United StatesDepartment of Neurology, University of California, Irvine, Irvine, CA, United StatesIntracranial artery calcifications (IAC), a common and easily identifiable finding on computed tomorgraphy angiography (CTA), has gained recognition as a possible risk factor for ischemic stroke. While atherosclerosis of intracranial arteries is believed to be a mechanism that commonly contributes to ischemic stroke, and coronary artery calcification is well-established as a predictor of both myocardial infarction (MI) and ischemic stroke risk, IAC is not currently used as a prognostic tool for stroke risk or recurrence. This review examines the pathophysiology and prevalence of IAC, and current evidence suggesting that IAC may be a useful tool for prediction of stroke incidence, recurrence, and response to acute ischemic stroke therapy.https://www.frontiersin.org/articles/10.3389/fneur.2022.900579/fullstrokecalcificationatherosclerosisimagingbiomarker |
| spellingShingle | Gianna M. Fote Sophia Raefsky Kelton Mock Amit Chaudhari Mohammad Shafie Wengui Yu Intracranial Arterial Calcifications: Potential Biomarkers of Stroke Risk and Outcome Frontiers in Neurology stroke calcification atherosclerosis imaging biomarker |
| title | Intracranial Arterial Calcifications: Potential Biomarkers of Stroke Risk and Outcome |
| title_full | Intracranial Arterial Calcifications: Potential Biomarkers of Stroke Risk and Outcome |
| title_fullStr | Intracranial Arterial Calcifications: Potential Biomarkers of Stroke Risk and Outcome |
| title_full_unstemmed | Intracranial Arterial Calcifications: Potential Biomarkers of Stroke Risk and Outcome |
| title_short | Intracranial Arterial Calcifications: Potential Biomarkers of Stroke Risk and Outcome |
| title_sort | intracranial arterial calcifications potential biomarkers of stroke risk and outcome |
| topic | stroke calcification atherosclerosis imaging biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.900579/full |
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