Are there differences in hepatitis-B immunization status between diabetes and non-diabetes subjects in Korea?
ObjectivesThe American Diabetes Association (ADA) recommends hepatitis-B virusVIruS vaccination for unvaccinated adults with diabetes. However, the Korean Diabetes Association (KDA) did not recommend hepatitis-B vaccination for unvaccinated adults with diabetes. This study was performed to assess th...
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| Format: | Article |
| Language: | English |
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Kosin University College of Medicine
2018-06-01
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| Series: | Kosin Medical Journal |
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| Online Access: | http://www.kosinmedj.org/upload/pdf/ksmc033-01-05.pdf |
| _version_ | 1811255722445373440 |
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| author | Ji Young Park Su Kyoung Kwon |
| author_facet | Ji Young Park Su Kyoung Kwon |
| author_sort | Ji Young Park |
| collection | DOAJ |
| description | ObjectivesThe American Diabetes Association (ADA) recommends hepatitis-B virusVIruS vaccination for unvaccinated adults with diabetes. However, the Korean Diabetes Association (KDA) did not recommend hepatitis-B vaccination for unvaccinated adults with diabetes. This study was performed to assess the differences in hepatitis-B virus antigen and antibody status between Korean patients with diabetes and those without by using national survey data. MethodsWe analyzed hepatitis-B virus antigen and antibody status in 9,771 South Korean people from the general population based on the Korean National Health and Nutrition Examination Survey. Diabetes patients were defined as those with a measured fasting plasma glucose over 126 mg/dL or those who had been previously diagnosed with diabetes by other health care centers. ResultsSubjects with diabetes accounted for 812 (8.3%) among the 9771 study subjects. The prevalence ofhepatitis-B (HBsAg) seropositive subjects was not significantly different (3.9% vs. 4.6%, P = 0.09) between subjects with diabetes and those without. The prevalence of hepatitis-B antibody (HBsAb) positive subjects and unimmunized subjects was not significantly different (55.2% vs. 58.2%, P = 0.09, 40.9% vs. 37.2%, P = 0.09) between the two groups. The prevalence of unimmunized subjects decreased by age (< 20 years 33.3 % vs. 33.0%, 20~29 years 49.1% vs. 41.2%, 30~39 years 41.9% vs. 37.7%, 40~49 years 35.1% vs. 33.5%, 50~59 years 39.0% vs. 38.0%, 60~69 years 41.2% vs. 39.8%, > 70 years 48.5% vs. 42.8%) but was not significantly different between the 2 groups. ConclusionsFrom this study, we conclude that there are not sufficient grounds to recommend routine hepatitis-B virus vaccination for unvaccinated Korean subjects with diabetes at this point in time in Korea. Further prospective studies will be needed. |
| first_indexed | 2024-04-12T17:29:08Z |
| format | Article |
| id | doaj.art-5b1c995a8b5142278d23980233ce0fb4 |
| institution | Directory Open Access Journal |
| issn | 2005-9531 2586-7024 |
| language | English |
| last_indexed | 2024-04-12T17:29:08Z |
| publishDate | 2018-06-01 |
| publisher | Kosin University College of Medicine |
| record_format | Article |
| series | Kosin Medical Journal |
| spelling | doaj.art-5b1c995a8b5142278d23980233ce0fb42022-12-22T03:23:11ZengKosin University College of MedicineKosin Medical Journal2005-95312586-70242018-06-01331415010.7180/kmj.2018.33.1.41211Are there differences in hepatitis-B immunization status between diabetes and non-diabetes subjects in Korea?Ji Young Park0Su Kyoung Kwon1Department of Internal Medicine, Division of Infection, College of Medicine, Kosin University, Busan, KoreaDepartment of Internal Medicine, Division of Endocrinology and Metabolism, College of Medicine, Kosin University, Busan, KoreaObjectivesThe American Diabetes Association (ADA) recommends hepatitis-B virusVIruS vaccination for unvaccinated adults with diabetes. However, the Korean Diabetes Association (KDA) did not recommend hepatitis-B vaccination for unvaccinated adults with diabetes. This study was performed to assess the differences in hepatitis-B virus antigen and antibody status between Korean patients with diabetes and those without by using national survey data. MethodsWe analyzed hepatitis-B virus antigen and antibody status in 9,771 South Korean people from the general population based on the Korean National Health and Nutrition Examination Survey. Diabetes patients were defined as those with a measured fasting plasma glucose over 126 mg/dL or those who had been previously diagnosed with diabetes by other health care centers. ResultsSubjects with diabetes accounted for 812 (8.3%) among the 9771 study subjects. The prevalence ofhepatitis-B (HBsAg) seropositive subjects was not significantly different (3.9% vs. 4.6%, P = 0.09) between subjects with diabetes and those without. The prevalence of hepatitis-B antibody (HBsAb) positive subjects and unimmunized subjects was not significantly different (55.2% vs. 58.2%, P = 0.09, 40.9% vs. 37.2%, P = 0.09) between the two groups. The prevalence of unimmunized subjects decreased by age (< 20 years 33.3 % vs. 33.0%, 20~29 years 49.1% vs. 41.2%, 30~39 years 41.9% vs. 37.7%, 40~49 years 35.1% vs. 33.5%, 50~59 years 39.0% vs. 38.0%, 60~69 years 41.2% vs. 39.8%, > 70 years 48.5% vs. 42.8%) but was not significantly different between the 2 groups. ConclusionsFrom this study, we conclude that there are not sufficient grounds to recommend routine hepatitis-B virus vaccination for unvaccinated Korean subjects with diabetes at this point in time in Korea. Further prospective studies will be needed.http://www.kosinmedj.org/upload/pdf/ksmc033-01-05.pdfdiabeteshepatitis bimmunizationkorean national health and nutrition |
| spellingShingle | Ji Young Park Su Kyoung Kwon Are there differences in hepatitis-B immunization status between diabetes and non-diabetes subjects in Korea? Kosin Medical Journal diabetes hepatitis b immunization korean national health and nutrition |
| title | Are there differences in hepatitis-B immunization status between diabetes and non-diabetes subjects in Korea? |
| title_full | Are there differences in hepatitis-B immunization status between diabetes and non-diabetes subjects in Korea? |
| title_fullStr | Are there differences in hepatitis-B immunization status between diabetes and non-diabetes subjects in Korea? |
| title_full_unstemmed | Are there differences in hepatitis-B immunization status between diabetes and non-diabetes subjects in Korea? |
| title_short | Are there differences in hepatitis-B immunization status between diabetes and non-diabetes subjects in Korea? |
| title_sort | are there differences in hepatitis b immunization status between diabetes and non diabetes subjects in korea |
| topic | diabetes hepatitis b immunization korean national health and nutrition |
| url | http://www.kosinmedj.org/upload/pdf/ksmc033-01-05.pdf |
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