Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma
Kidney cancer encompasses a range of primary cancers, such as clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC). Our knowledge about the tumor microenvironment (TME) of kidney cancer is still limited. Therefore, we comprehensively assessed the TME of kidney cancers (i...
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| Format: | Article |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.760031/full |
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| author | Bin Zheng Bin Zheng Bin Zheng Fang Xie Fang Xie Fajuan Cheng Fajuan Cheng Fajuan Cheng Jianwei Wang Zhongshun Yao Zhongshun Yao Wei He Wei He Wei He Zhihong Niu Zhihong Niu Zhihong Niu |
| author_facet | Bin Zheng Bin Zheng Bin Zheng Fang Xie Fang Xie Fajuan Cheng Fajuan Cheng Fajuan Cheng Jianwei Wang Zhongshun Yao Zhongshun Yao Wei He Wei He Wei He Zhihong Niu Zhihong Niu Zhihong Niu |
| author_sort | Bin Zheng |
| collection | DOAJ |
| description | Kidney cancer encompasses a range of primary cancers, such as clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC). Our knowledge about the tumor microenvironment (TME) of kidney cancer is still limited. Therefore, we comprehensively assessed the TME of kidney cancers (including ccRCC and pRCC) using the ESTIAMTE, and CIBERSORT algorithms, and conducted distinct functional and correlation analyses with data from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Gene Expression Omnibus (GEO), Connectivity map and CellMiner database. Next, we identified two immune-related hub genes, IGLL5 and IL2RA, which play essential roles in the TME as well as on survival in ccRCC and pRCC. Furthermore, ccRCC and pRCC samples from our medical center were collected to verify the clinical application value of these two immune-related genes. A specific enrichment analysis of immune cells related to IGLL5 and IL2RA was also conducted in two types of renal cell cancer. Based on selected genes, we predicted the drug response and uncovered novel drug candidate for RCC treatment. Considering the unfavorable outcomes of kidney cancer and emerging interest in TME-targeted treatments, our results may offer insights into immune-related molecular mechanisms and possible targets to control the kidney cancer. |
| first_indexed | 2024-12-15T00:19:01Z |
| format | Article |
| id | doaj.art-5b1cd164c05b4bfc87d83cae0d531212 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-15T00:19:01Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-5b1cd164c05b4bfc87d83cae0d5312122022-12-21T22:42:22ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-11-01810.3389/fmolb.2021.760031760031Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell CarcinomaBin Zheng0Bin Zheng1Bin Zheng2Fang Xie3Fang Xie4Fajuan Cheng5Fajuan Cheng6Fajuan Cheng7Jianwei Wang8Zhongshun Yao9Zhongshun Yao10Wei He11Wei He12Wei He13Zhihong Niu14Zhihong Niu15Zhihong Niu16Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Urology, Weihai Municipal Hospital, Weihai, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, ChinaDepartment of Nephrology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Urology, Shandong Provincial ENT Hospital Affiliated to Shandong University, Jinan, ChinaDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, ChinaKidney cancer encompasses a range of primary cancers, such as clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC). Our knowledge about the tumor microenvironment (TME) of kidney cancer is still limited. Therefore, we comprehensively assessed the TME of kidney cancers (including ccRCC and pRCC) using the ESTIAMTE, and CIBERSORT algorithms, and conducted distinct functional and correlation analyses with data from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Gene Expression Omnibus (GEO), Connectivity map and CellMiner database. Next, we identified two immune-related hub genes, IGLL5 and IL2RA, which play essential roles in the TME as well as on survival in ccRCC and pRCC. Furthermore, ccRCC and pRCC samples from our medical center were collected to verify the clinical application value of these two immune-related genes. A specific enrichment analysis of immune cells related to IGLL5 and IL2RA was also conducted in two types of renal cell cancer. Based on selected genes, we predicted the drug response and uncovered novel drug candidate for RCC treatment. Considering the unfavorable outcomes of kidney cancer and emerging interest in TME-targeted treatments, our results may offer insights into immune-related molecular mechanisms and possible targets to control the kidney cancer.https://www.frontiersin.org/articles/10.3389/fmolb.2021.760031/fullclear cell renal carcinomapapillary renal cell carcinomaprognosistumor microenvironmentimmunotherapy |
| spellingShingle | Bin Zheng Bin Zheng Bin Zheng Fang Xie Fang Xie Fajuan Cheng Fajuan Cheng Fajuan Cheng Jianwei Wang Zhongshun Yao Zhongshun Yao Wei He Wei He Wei He Zhihong Niu Zhihong Niu Zhihong Niu Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma Frontiers in Molecular Biosciences clear cell renal carcinoma papillary renal cell carcinoma prognosis tumor microenvironment immunotherapy |
| title | Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma |
| title_full | Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma |
| title_fullStr | Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma |
| title_full_unstemmed | Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma |
| title_short | Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma |
| title_sort | integrative analysis of immune related genes in the tumor microenvironment of renal clear cell carcinoma and renal papillary cell carcinoma |
| topic | clear cell renal carcinoma papillary renal cell carcinoma prognosis tumor microenvironment immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.760031/full |
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