Targeting survivin in leukemia
Survivin, a member of the inhibitors of apoptosis family of proteins, is one of the most frequently upregulated transcripts in solid tumors and hematopoietic malignancies. Survivin’s importance in tumorigenesis is attributed to the fact that it has two functions: to suppress apoptosis and to regulat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-12-01
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| Series: | Oncology Reviews |
| Subjects: | |
| Online Access: | http://www.oncologyreviews.org/index.php/or/article/view/156 |
| _version_ | 1797966251765530624 |
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| author | Bing Z. Carter Michael Andreeff |
| author_facet | Bing Z. Carter Michael Andreeff |
| author_sort | Bing Z. Carter |
| collection | DOAJ |
| description | Survivin, a member of the inhibitors of apoptosis family of proteins, is one of the most frequently upregulated transcripts in solid tumors and hematopoietic malignancies. Survivin’s importance in tumorigenesis is attributed to the fact that it has two functions: to suppress apoptosis and to regulate cell division. The combination of these two functions gives a significant growth and survival advantage on neoplastic cells. This, together with its overexpression in cancer cells, its association with resistance to chemo- and other therapies, and the resulting poor prognosis observed in certain tumors makes survivin a promising target for therapy. In this review, we describe what is currently know about survivin regulation in normal and malignant cells, focusing in particular on the aberrant expression of the protein in leukemia and its possible clinical implications. Various strategies to target survivin will also be described. |
| first_indexed | 2024-04-11T02:12:48Z |
| format | Article |
| id | doaj.art-5b1e3581c420496ca6cb7bf07cf97a9e |
| institution | Directory Open Access Journal |
| issn | 1970-5557 1970-5565 |
| language | English |
| last_indexed | 2024-04-11T02:12:48Z |
| publishDate | 2011-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj.art-5b1e3581c420496ca6cb7bf07cf97a9e2023-01-03T01:51:44ZengFrontiers Media S.A.Oncology Reviews1970-55571970-55652011-12-0114Targeting survivin in leukemiaBing Z. Carter0Michael Andreeff1Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation and Cellular Therapy, HoustonDepartment of Leukemia, The University of Texas M.D. Anderson Cancer Center and Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation and Cellular Therapy, HoustonSurvivin, a member of the inhibitors of apoptosis family of proteins, is one of the most frequently upregulated transcripts in solid tumors and hematopoietic malignancies. Survivin’s importance in tumorigenesis is attributed to the fact that it has two functions: to suppress apoptosis and to regulate cell division. The combination of these two functions gives a significant growth and survival advantage on neoplastic cells. This, together with its overexpression in cancer cells, its association with resistance to chemo- and other therapies, and the resulting poor prognosis observed in certain tumors makes survivin a promising target for therapy. In this review, we describe what is currently know about survivin regulation in normal and malignant cells, focusing in particular on the aberrant expression of the protein in leukemia and its possible clinical implications. Various strategies to target survivin will also be described.http://www.oncologyreviews.org/index.php/or/article/view/156Survivin - Leukemia - IAPs - Expression - Targeting |
| spellingShingle | Bing Z. Carter Michael Andreeff Targeting survivin in leukemia Oncology Reviews Survivin - Leukemia - IAPs - Expression - Targeting |
| title | Targeting survivin in leukemia |
| title_full | Targeting survivin in leukemia |
| title_fullStr | Targeting survivin in leukemia |
| title_full_unstemmed | Targeting survivin in leukemia |
| title_short | Targeting survivin in leukemia |
| title_sort | targeting survivin in leukemia |
| topic | Survivin - Leukemia - IAPs - Expression - Targeting |
| url | http://www.oncologyreviews.org/index.php/or/article/view/156 |
| work_keys_str_mv | AT bingzcarter targetingsurvivininleukemia AT michaelandreeff targetingsurvivininleukemia |