Analysis of comorbidity in rheumatoid arthritis–associated interstitial lung disease: a nested case-cohort study
Objectives: To describe comorbid conditions in patients with rheumatoid arthritis–associated interstitial lung disease (RA-ILD) and to analyze factors associated with multimorbidity. Methods: Nested case-cohort study of 2 prospective cohorts: one with RA-ILD (cases) and another with RA but not ILD (...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222201438X |
| _version_ | 1811178928382935040 |
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| author | Natalia Mena-Vázquez Marta Rojas-Gimenez Carmen María Romero-Barco Myriam Gandía-Martínez Nair Perez-Gómez Francisco Javier Godoy-Navarrete Sara Manrique-Arija Aimara Garcia-Studer Jerusalem Calvo-Gutiérrez Clara Fuego Varela Pilar Morales-Garrido Patricia Castro Pérez Coral Mouriño-Rodriguez Isabel Añón-Oñate Francisco Espildora María Carmen Aguilar-Hurtado Rocío Redondo Ana Hidalgo Conde Rocío Arnedo Díez de los Ríos Eva Cabrera César Maria Luisa Velloso-Feijoo Antonio Fernández-Nebro |
| author_facet | Natalia Mena-Vázquez Marta Rojas-Gimenez Carmen María Romero-Barco Myriam Gandía-Martínez Nair Perez-Gómez Francisco Javier Godoy-Navarrete Sara Manrique-Arija Aimara Garcia-Studer Jerusalem Calvo-Gutiérrez Clara Fuego Varela Pilar Morales-Garrido Patricia Castro Pérez Coral Mouriño-Rodriguez Isabel Añón-Oñate Francisco Espildora María Carmen Aguilar-Hurtado Rocío Redondo Ana Hidalgo Conde Rocío Arnedo Díez de los Ríos Eva Cabrera César Maria Luisa Velloso-Feijoo Antonio Fernández-Nebro |
| author_sort | Natalia Mena-Vázquez |
| collection | DOAJ |
| description | Objectives: To describe comorbid conditions in patients with rheumatoid arthritis–associated interstitial lung disease (RA-ILD) and to analyze factors associated with multimorbidity. Methods: Nested case-cohort study of 2 prospective cohorts: one with RA-ILD (cases) and another with RA but not ILD (controls). The cohorts were matched for age, sex, and time since diagnosis. Multimorbidity was defined as the co-occurrence of 2 or more chronic diseases, in addition to RA and ILD. We evaluated the comorbid conditions included in the Charlson Comorbidity Index, cardiovascular risk factors, neuropsychiatric conditions, and other frequent conditions in RA. We also recorded clinical-laboratory variables, inflammatory activity according to the 28-joint Disease Activity Score, C-reactive protein (CRP), physical function, and pulmonary function. We performed 2 multivariate analyses to identify factors associated with multimorbidity in RA and RA-ILD. Results: The final study population comprised 110 cases and 104 controls. Multimorbidity was more frequent among cases than controls (80 [72.7] vs 60 [57.7]; p = 0.021). In both groups, multimorbidity was associated with ILD (OR [95% CI] 1.92 [1.03–3.59]; p = 0.039), age (OR [95% CI] 1.05 [1.01–1.08]; p = 0.004), CRP (OR [95% CI] 1.16 [1.05–1.29]; p = 0.003), and erosions (OR [95% CI] 1.05 [1.01–1.08]; p = 0.004); in the cases, it was associated with CRP (OR [95% CI] 1.17 [1.01–1.35]; p = 0.027), anti–citrullinated peptide antibody (OR [95% CI] 1.23 [1.14–13.02]; p = 0.049), and forced vital capacity (OR [95% CI] 0.79 [0.96–0.99]; p = 0.036). Conclusion: In patients with RA, multimorbidity was associated with ILD, systemic inflammation, and advanced age. |
| first_indexed | 2024-04-11T06:26:14Z |
| format | Article |
| id | doaj.art-5b210f3fc3134ae4993990e51792405c |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T06:26:14Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-5b210f3fc3134ae4993990e51792405c2022-12-22T04:40:21ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-01-01157114049Analysis of comorbidity in rheumatoid arthritis–associated interstitial lung disease: a nested case-cohort studyNatalia Mena-Vázquez0Marta Rojas-Gimenez1Carmen María Romero-Barco2Myriam Gandía-Martínez3Nair Perez-Gómez4Francisco Javier Godoy-Navarrete5Sara Manrique-Arija6Aimara Garcia-Studer7Jerusalem Calvo-Gutiérrez8Clara Fuego Varela9Pilar Morales-Garrido10Patricia Castro Pérez11Coral Mouriño-Rodriguez12Isabel Añón-Oñate13Francisco Espildora14María Carmen Aguilar-Hurtado15Rocío Redondo16Ana Hidalgo Conde17Rocío Arnedo Díez de los Ríos18Eva Cabrera César19Maria Luisa Velloso-Feijoo20Antonio Fernández-Nebro21Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain; UGC de Reumatología, Hospital Regional Universitario de Málaga, 29009 Málaga, Spain; Correspondence to: UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma Bionand, Hospital Regional Universitario de Málaga, Plaza del Hospital Civil s/n., 29009 Malaga, Spain.Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain; UGC de Reumatología, Hospital Universitario Reina Sofía de Córdoba, 14004 Córdoba, SpainInstituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain; UGC de Reumatología, Hospital Clínico Universitario Virgen de la Victoria, 29010 Málaga, SpainUGC de Reumatología, Hospital Universitario de Jerez, 11407 Cádiz, SpainUGC de Reumatología, Complejo Hospitalario Universitario de Vigo, 36214 Vigo, SpainHospital Universitario de Jaén, Jaén, SpainInstituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain; UGC de Reumatología, Hospital Regional Universitario de Málaga, 29009 Málaga, Spain; Departamento de Medicina. Universidad de Málaga, 29010 Málaga, SpainInstituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain; UGC de Reumatología, Hospital Regional Universitario de Málaga, 29009 Málaga, SpainInstituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain; UGC de Reumatología, Hospital Universitario Reina Sofía de Córdoba, 14004 Córdoba, SpainUGC de Reumatología, Hospital Universitario de Jerez, 11407 Cádiz, SpainUGC de Reumatología, Hospital Universitario Clínico San Cecilio, 18016 Granada, SpainUGC de Reumatología, Hospital Universitario de Getafe, Madrid, SpainUGC de Reumatología, Complejo Hospitalario Universitario de Vigo, 36214 Vigo, SpainHospital Universitario de Jaén, Jaén, SpainUGC de Neumología, Hospital Regional Universitario de Málaga, 29009 Málaga, SpainUGC de Radiodiagnóstico, Hospital Regional Universitario de Málaga, 29009 Málaga, SpainInstituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain; UGC de Reumatología, Hospital Regional Universitario de Málaga, 29009 Málaga, SpainServicio de Medicina Interna, Hospital Universitario Virgen de la Victoria, 29010 Málaga, SpainServicio de Medicina Interna, Hospital Universitario Virgen de la Victoria, 29010 Málaga, SpainUGC Neumología, Hospital Universitario Virgen de la Victoria, 29010 Málaga, SpainHospital Universitario Virgen de Valme, Sevilla, SpainInstituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain; UGC de Reumatología, Hospital Regional Universitario de Málaga, 29009 Málaga, Spain; Departamento de Medicina. Universidad de Málaga, 29010 Málaga, SpainObjectives: To describe comorbid conditions in patients with rheumatoid arthritis–associated interstitial lung disease (RA-ILD) and to analyze factors associated with multimorbidity. Methods: Nested case-cohort study of 2 prospective cohorts: one with RA-ILD (cases) and another with RA but not ILD (controls). The cohorts were matched for age, sex, and time since diagnosis. Multimorbidity was defined as the co-occurrence of 2 or more chronic diseases, in addition to RA and ILD. We evaluated the comorbid conditions included in the Charlson Comorbidity Index, cardiovascular risk factors, neuropsychiatric conditions, and other frequent conditions in RA. We also recorded clinical-laboratory variables, inflammatory activity according to the 28-joint Disease Activity Score, C-reactive protein (CRP), physical function, and pulmonary function. We performed 2 multivariate analyses to identify factors associated with multimorbidity in RA and RA-ILD. Results: The final study population comprised 110 cases and 104 controls. Multimorbidity was more frequent among cases than controls (80 [72.7] vs 60 [57.7]; p = 0.021). In both groups, multimorbidity was associated with ILD (OR [95% CI] 1.92 [1.03–3.59]; p = 0.039), age (OR [95% CI] 1.05 [1.01–1.08]; p = 0.004), CRP (OR [95% CI] 1.16 [1.05–1.29]; p = 0.003), and erosions (OR [95% CI] 1.05 [1.01–1.08]; p = 0.004); in the cases, it was associated with CRP (OR [95% CI] 1.17 [1.01–1.35]; p = 0.027), anti–citrullinated peptide antibody (OR [95% CI] 1.23 [1.14–13.02]; p = 0.049), and forced vital capacity (OR [95% CI] 0.79 [0.96–0.99]; p = 0.036). Conclusion: In patients with RA, multimorbidity was associated with ILD, systemic inflammation, and advanced age.http://www.sciencedirect.com/science/article/pii/S075333222201438XRheumatoid arthritisInterstitial lung diseaseComorbidityMultimorbidityInflammation |
| spellingShingle | Natalia Mena-Vázquez Marta Rojas-Gimenez Carmen María Romero-Barco Myriam Gandía-Martínez Nair Perez-Gómez Francisco Javier Godoy-Navarrete Sara Manrique-Arija Aimara Garcia-Studer Jerusalem Calvo-Gutiérrez Clara Fuego Varela Pilar Morales-Garrido Patricia Castro Pérez Coral Mouriño-Rodriguez Isabel Añón-Oñate Francisco Espildora María Carmen Aguilar-Hurtado Rocío Redondo Ana Hidalgo Conde Rocío Arnedo Díez de los Ríos Eva Cabrera César Maria Luisa Velloso-Feijoo Antonio Fernández-Nebro Analysis of comorbidity in rheumatoid arthritis–associated interstitial lung disease: a nested case-cohort study Biomedicine & Pharmacotherapy Rheumatoid arthritis Interstitial lung disease Comorbidity Multimorbidity Inflammation |
| title | Analysis of comorbidity in rheumatoid arthritis–associated interstitial lung disease: a nested case-cohort study |
| title_full | Analysis of comorbidity in rheumatoid arthritis–associated interstitial lung disease: a nested case-cohort study |
| title_fullStr | Analysis of comorbidity in rheumatoid arthritis–associated interstitial lung disease: a nested case-cohort study |
| title_full_unstemmed | Analysis of comorbidity in rheumatoid arthritis–associated interstitial lung disease: a nested case-cohort study |
| title_short | Analysis of comorbidity in rheumatoid arthritis–associated interstitial lung disease: a nested case-cohort study |
| title_sort | analysis of comorbidity in rheumatoid arthritis associated interstitial lung disease a nested case cohort study |
| topic | Rheumatoid arthritis Interstitial lung disease Comorbidity Multimorbidity Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S075333222201438X |
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