Biological Potential of Polyphenols in the Context of Metabolic Syndrome: An Analysis of Studies on Animal Models
Metabolic syndrome (MetS) is a disease that has a complex etiology. It is defined as the co-occurrence of several pathophysiological disorders, including obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is currently a severe problem in the public health care system. As its prevalence inc...
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MDPI AG
2022-04-01
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| Online Access: | https://www.mdpi.com/2079-7737/11/4/559 |
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| author | Joanna Niewiadomska Aleksandra Gajek-Marecka Jacek Gajek Agnieszka Noszczyk-Nowak |
| author_facet | Joanna Niewiadomska Aleksandra Gajek-Marecka Jacek Gajek Agnieszka Noszczyk-Nowak |
| author_sort | Joanna Niewiadomska |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) is a disease that has a complex etiology. It is defined as the co-occurrence of several pathophysiological disorders, including obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is currently a severe problem in the public health care system. As its prevalence increases every year, it is now considered a global problem among adults and young populations. The treatment of choice comprises lifestyle changes based mainly on diet and physical activity. Therefore, researchers have been attempting to discover new substances that could help reduce or even reverse the symptoms when added to food. These attempts have resulted in numerous studies. Many of them have investigated the bioactive potential of polyphenols as a “possible remedy”, stemming from their antioxidative and anti-inflammatory effects and properties normalizing carbohydrate and lipid metabolism. Polyphenols may be supportive in preventing or delaying the onset of MetS or its complications. Additionally, the consumption of food rich in polyphenols should be considered as a supplement for antidiabetic drugs. To ensure the relevance of the studies on polyphenols’ properties, mechanisms of action, and potential human health benefits, researchers have used laboratory animals displaying pathophysiological changes specific to MetS. Polyphenols or their plant extracts were chosen according to the most advantageous mitigation of pathological changes in animal models best reflecting the components of MetS. The present paper comprises an overview of animal models of MetS, and promising polyphenolic compounds whose bioactive potential, effect on metabolic pathways, and supplementation-related benefits were analyzed based on in vivo animal models. |
| first_indexed | 2024-03-09T11:08:03Z |
| format | Article |
| id | doaj.art-5b219acab6374b2895de662d297cf972 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T11:08:03Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-5b219acab6374b2895de662d297cf9722023-12-01T00:51:31ZengMDPI AGBiology2079-77372022-04-0111455910.3390/biology11040559Biological Potential of Polyphenols in the Context of Metabolic Syndrome: An Analysis of Studies on Animal ModelsJoanna Niewiadomska0Aleksandra Gajek-Marecka1Jacek Gajek2Agnieszka Noszczyk-Nowak3Doctoral School of Wroclaw, University of Environmental and Life Sciences, 50-375 Wroclaw, PolandDepartment of Cardiology, Kłodzko County Hospital, 57-300 Kłodzko, PolandDepartment of Emergency Medical Service, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Internal and Diseases with Clinic for Horses, Dogs, and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, PolandMetabolic syndrome (MetS) is a disease that has a complex etiology. It is defined as the co-occurrence of several pathophysiological disorders, including obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is currently a severe problem in the public health care system. As its prevalence increases every year, it is now considered a global problem among adults and young populations. The treatment of choice comprises lifestyle changes based mainly on diet and physical activity. Therefore, researchers have been attempting to discover new substances that could help reduce or even reverse the symptoms when added to food. These attempts have resulted in numerous studies. Many of them have investigated the bioactive potential of polyphenols as a “possible remedy”, stemming from their antioxidative and anti-inflammatory effects and properties normalizing carbohydrate and lipid metabolism. Polyphenols may be supportive in preventing or delaying the onset of MetS or its complications. Additionally, the consumption of food rich in polyphenols should be considered as a supplement for antidiabetic drugs. To ensure the relevance of the studies on polyphenols’ properties, mechanisms of action, and potential human health benefits, researchers have used laboratory animals displaying pathophysiological changes specific to MetS. Polyphenols or their plant extracts were chosen according to the most advantageous mitigation of pathological changes in animal models best reflecting the components of MetS. The present paper comprises an overview of animal models of MetS, and promising polyphenolic compounds whose bioactive potential, effect on metabolic pathways, and supplementation-related benefits were analyzed based on in vivo animal models.https://www.mdpi.com/2079-7737/11/4/559polyphenolslaboratory animal modelsmetabolic syndrome |
| spellingShingle | Joanna Niewiadomska Aleksandra Gajek-Marecka Jacek Gajek Agnieszka Noszczyk-Nowak Biological Potential of Polyphenols in the Context of Metabolic Syndrome: An Analysis of Studies on Animal Models Biology polyphenols laboratory animal models metabolic syndrome |
| title | Biological Potential of Polyphenols in the Context of Metabolic Syndrome: An Analysis of Studies on Animal Models |
| title_full | Biological Potential of Polyphenols in the Context of Metabolic Syndrome: An Analysis of Studies on Animal Models |
| title_fullStr | Biological Potential of Polyphenols in the Context of Metabolic Syndrome: An Analysis of Studies on Animal Models |
| title_full_unstemmed | Biological Potential of Polyphenols in the Context of Metabolic Syndrome: An Analysis of Studies on Animal Models |
| title_short | Biological Potential of Polyphenols in the Context of Metabolic Syndrome: An Analysis of Studies on Animal Models |
| title_sort | biological potential of polyphenols in the context of metabolic syndrome an analysis of studies on animal models |
| topic | polyphenols laboratory animal models metabolic syndrome |
| url | https://www.mdpi.com/2079-7737/11/4/559 |
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