Cellular senescence and the tumour microenvironment
The senescence‐associated secretory phenotype (SASP), where senescent cells produce a variety of secreted proteins including inflammatory cytokines, chemokines, matrix remodelling factors, growth factors and so on, plays pivotal but varying roles in the tumour microenvironment. The effects of SASP o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-09-01
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| Series: | Molecular Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/1878-0261.13268 |
| _version_ | 1811183669084160000 |
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| author | Masaki Takasugi Yuya Yoshida Naoko Ohtani |
| author_facet | Masaki Takasugi Yuya Yoshida Naoko Ohtani |
| author_sort | Masaki Takasugi |
| collection | DOAJ |
| description | The senescence‐associated secretory phenotype (SASP), where senescent cells produce a variety of secreted proteins including inflammatory cytokines, chemokines, matrix remodelling factors, growth factors and so on, plays pivotal but varying roles in the tumour microenvironment. The effects of SASP on the surrounding microenvironment depend on the cell type and process of cellular senescence induction, which is often associated with innate immunity. Via SASP‐mediated paracrine effects, senescent cells can remodel the surrounding tissues by modulating the character of adjacent cells, such as stromal, immune cells, as well as cancer cells. The SASP is associated with both tumour‐suppressive and tumour‐promoting effects, as observed in senescence surveillance effects (tumour‐suppressive) and suppression of anti‐tumour immunity in most senescent cancer‐associated fibroblasts and senescent T cells (tumour‐promoting). In this review, we discuss the features and roles of senescent cells in tumour microenvironment with emphasis on their context‐dependency that determines whether they promote or suppress cancer development. Potential usage of recently developed drugs that suppress the SASP (senomorphics) or selectively kill senescence cells (senolytics) in cancer therapy are also discussed. |
| first_indexed | 2024-04-11T09:50:38Z |
| format | Article |
| id | doaj.art-5b22375b885d41c5871cb7b6dc813e06 |
| institution | Directory Open Access Journal |
| issn | 1574-7891 1878-0261 |
| language | English |
| last_indexed | 2024-04-11T09:50:38Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Oncology |
| spelling | doaj.art-5b22375b885d41c5871cb7b6dc813e062022-12-22T04:30:48ZengWileyMolecular Oncology1574-78911878-02612022-09-0116183333335110.1002/1878-0261.13268Cellular senescence and the tumour microenvironmentMasaki Takasugi0Yuya Yoshida1Naoko Ohtani2Department of Pathophysiology, Graduate School of Medicine Osaka Metropolitan University (formerly, Osaka City University) Osaka JapanDepartment of Pathophysiology, Graduate School of Medicine Osaka Metropolitan University (formerly, Osaka City University) Osaka JapanDepartment of Pathophysiology, Graduate School of Medicine Osaka Metropolitan University (formerly, Osaka City University) Osaka JapanThe senescence‐associated secretory phenotype (SASP), where senescent cells produce a variety of secreted proteins including inflammatory cytokines, chemokines, matrix remodelling factors, growth factors and so on, plays pivotal but varying roles in the tumour microenvironment. The effects of SASP on the surrounding microenvironment depend on the cell type and process of cellular senescence induction, which is often associated with innate immunity. Via SASP‐mediated paracrine effects, senescent cells can remodel the surrounding tissues by modulating the character of adjacent cells, such as stromal, immune cells, as well as cancer cells. The SASP is associated with both tumour‐suppressive and tumour‐promoting effects, as observed in senescence surveillance effects (tumour‐suppressive) and suppression of anti‐tumour immunity in most senescent cancer‐associated fibroblasts and senescent T cells (tumour‐promoting). In this review, we discuss the features and roles of senescent cells in tumour microenvironment with emphasis on their context‐dependency that determines whether they promote or suppress cancer development. Potential usage of recently developed drugs that suppress the SASP (senomorphics) or selectively kill senescence cells (senolytics) in cancer therapy are also discussed.https://doi.org/10.1002/1878-0261.13268anti‐tumour immunitycellular senescencesenescence‐associated secretory phenotypesenolysissenomorphicstumour microenvironment |
| spellingShingle | Masaki Takasugi Yuya Yoshida Naoko Ohtani Cellular senescence and the tumour microenvironment Molecular Oncology anti‐tumour immunity cellular senescence senescence‐associated secretory phenotype senolysis senomorphics tumour microenvironment |
| title | Cellular senescence and the tumour microenvironment |
| title_full | Cellular senescence and the tumour microenvironment |
| title_fullStr | Cellular senescence and the tumour microenvironment |
| title_full_unstemmed | Cellular senescence and the tumour microenvironment |
| title_short | Cellular senescence and the tumour microenvironment |
| title_sort | cellular senescence and the tumour microenvironment |
| topic | anti‐tumour immunity cellular senescence senescence‐associated secretory phenotype senolysis senomorphics tumour microenvironment |
| url | https://doi.org/10.1002/1878-0261.13268 |
| work_keys_str_mv | AT masakitakasugi cellularsenescenceandthetumourmicroenvironment AT yuyayoshida cellularsenescenceandthetumourmicroenvironment AT naokoohtani cellularsenescenceandthetumourmicroenvironment |