High-Density Lipoproteins and Mediterranean Diet: A Systematic Review
Cardiovascular disease (CVD) is the leading cause of global mortality and the study of high-density lipoproteins (HDL) particle composition and functionality has become a matter of high interest, particularly in light to the disappointing clinical data for HDL-cholesterol (HDL-C) raising therapies i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/3/955 |
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| author | Elena Grao-Cruces Lourdes M. Varela Maria E. Martin Beatriz Bermudez Sergio Montserrat-de la Paz |
| author_facet | Elena Grao-Cruces Lourdes M. Varela Maria E. Martin Beatriz Bermudez Sergio Montserrat-de la Paz |
| author_sort | Elena Grao-Cruces |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is the leading cause of global mortality and the study of high-density lipoproteins (HDL) particle composition and functionality has become a matter of high interest, particularly in light to the disappointing clinical data for HDL-cholesterol (HDL-C) raising therapies in CVD secondary prevention and the lack of association between HDL-C and the risk of CVD. Recent evidences suggest that HDL composition and functionality could be modulated by diet. The purpose of this systematic review was to investigate the effect of Mediterranean diet (MD) on changes in HDL structure and functionality in humans. A comprehensive search was conducted in four databases (PubMed, Scopus, Cochrane library and Web of Science) and 13 records were chosen. MD showed favorable effects on HDL functionality, particularly by improving HDL cholesterol efflux capacity and decreasing HDL oxidation. In addition, HDL composition and size were influenced by MD. Thus, MD is a protective factor against CVD associated with the improvement of HDL quality and the prevention of HDL dysfunctionality. |
| first_indexed | 2024-03-10T13:12:31Z |
| format | Article |
| id | doaj.art-5b22b9bb399f417cbef7bc0baf95e34d |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T13:12:31Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-5b22b9bb399f417cbef7bc0baf95e34d2023-11-21T10:39:49ZengMDPI AGNutrients2072-66432021-03-0113395510.3390/nu13030955High-Density Lipoproteins and Mediterranean Diet: A Systematic ReviewElena Grao-Cruces0Lourdes M. Varela1Maria E. Martin2Beatriz Bermudez3Sergio Montserrat-de la Paz4Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, 41009 Seville, SpainInstitute of Biomedicine of Seville, IBiS, Universitary Hospital Virgen del Rocio/CSIC/University of Seville, 41013 Seville, SpainDepartment of Cell Biology, Faculty of Biology, University of Seville, 41012 Seville, SpainDepartment of Cell Biology, Faculty of Biology, University of Seville, 41012 Seville, SpainDepartment of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, 41009 Seville, SpainCardiovascular disease (CVD) is the leading cause of global mortality and the study of high-density lipoproteins (HDL) particle composition and functionality has become a matter of high interest, particularly in light to the disappointing clinical data for HDL-cholesterol (HDL-C) raising therapies in CVD secondary prevention and the lack of association between HDL-C and the risk of CVD. Recent evidences suggest that HDL composition and functionality could be modulated by diet. The purpose of this systematic review was to investigate the effect of Mediterranean diet (MD) on changes in HDL structure and functionality in humans. A comprehensive search was conducted in four databases (PubMed, Scopus, Cochrane library and Web of Science) and 13 records were chosen. MD showed favorable effects on HDL functionality, particularly by improving HDL cholesterol efflux capacity and decreasing HDL oxidation. In addition, HDL composition and size were influenced by MD. Thus, MD is a protective factor against CVD associated with the improvement of HDL quality and the prevention of HDL dysfunctionality.https://www.mdpi.com/2072-6643/13/3/955high-density lipoproteinlipidomeproteomeMediterranean dietolive oil |
| spellingShingle | Elena Grao-Cruces Lourdes M. Varela Maria E. Martin Beatriz Bermudez Sergio Montserrat-de la Paz High-Density Lipoproteins and Mediterranean Diet: A Systematic Review Nutrients high-density lipoprotein lipidome proteome Mediterranean diet olive oil |
| title | High-Density Lipoproteins and Mediterranean Diet: A Systematic Review |
| title_full | High-Density Lipoproteins and Mediterranean Diet: A Systematic Review |
| title_fullStr | High-Density Lipoproteins and Mediterranean Diet: A Systematic Review |
| title_full_unstemmed | High-Density Lipoproteins and Mediterranean Diet: A Systematic Review |
| title_short | High-Density Lipoproteins and Mediterranean Diet: A Systematic Review |
| title_sort | high density lipoproteins and mediterranean diet a systematic review |
| topic | high-density lipoprotein lipidome proteome Mediterranean diet olive oil |
| url | https://www.mdpi.com/2072-6643/13/3/955 |
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