The impact of mass drug administration of antibiotics on the gut microbiota of target populations
Abstract Antibiotics have become a mainstay of healthcare in the past century due to their activity against pathogens. This manuscript reviews the impact of antibiotic use on the intestinal microbiota in the context of mass drug administration (MDA). The importance of the gut microbiota to human met...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Infectious Diseases of Poverty |
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| Online Access: | https://doi.org/10.1186/s40249-022-00999-5 |
| _version_ | 1811328525234339840 |
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| author | Ethan K. Gough |
| author_facet | Ethan K. Gough |
| author_sort | Ethan K. Gough |
| collection | DOAJ |
| description | Abstract Antibiotics have become a mainstay of healthcare in the past century due to their activity against pathogens. This manuscript reviews the impact of antibiotic use on the intestinal microbiota in the context of mass drug administration (MDA). The importance of the gut microbiota to human metabolism and physiology is now well established, and antibiotic exposure may impact host health via collateral effects on the microbiota and its functions. To gain further insight into how gut microbiota respond to antibiotic perturbation and the implications for public health, factors that influence the impact of antibiotic exposure on the microbiota, potential health outcomes of antibiotic-induced microbiota alterations, and strategies that have the potential to ameliorate these wider antibiotic-associated microbiota perturbations are also reviewed. Graphical Abstract |
| first_indexed | 2024-04-13T15:27:41Z |
| format | Article |
| id | doaj.art-5b242ca170e9431da14eb08497e4c59c |
| institution | Directory Open Access Journal |
| issn | 2049-9957 |
| language | English |
| last_indexed | 2024-04-13T15:27:41Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Diseases of Poverty |
| spelling | doaj.art-5b242ca170e9431da14eb08497e4c59c2022-12-22T02:41:28ZengBMCInfectious Diseases of Poverty2049-99572022-06-0111112010.1186/s40249-022-00999-5The impact of mass drug administration of antibiotics on the gut microbiota of target populationsEthan K. Gough0Department of International Health, Human Nutrition Program, Johns Hopkins Bloomberg School of Public HealthAbstract Antibiotics have become a mainstay of healthcare in the past century due to their activity against pathogens. This manuscript reviews the impact of antibiotic use on the intestinal microbiota in the context of mass drug administration (MDA). The importance of the gut microbiota to human metabolism and physiology is now well established, and antibiotic exposure may impact host health via collateral effects on the microbiota and its functions. To gain further insight into how gut microbiota respond to antibiotic perturbation and the implications for public health, factors that influence the impact of antibiotic exposure on the microbiota, potential health outcomes of antibiotic-induced microbiota alterations, and strategies that have the potential to ameliorate these wider antibiotic-associated microbiota perturbations are also reviewed. Graphical Abstracthttps://doi.org/10.1186/s40249-022-00999-5AntibioticsMass drug administrationMicrobiotaMicrobiome |
| spellingShingle | Ethan K. Gough The impact of mass drug administration of antibiotics on the gut microbiota of target populations Infectious Diseases of Poverty Antibiotics Mass drug administration Microbiota Microbiome |
| title | The impact of mass drug administration of antibiotics on the gut microbiota of target populations |
| title_full | The impact of mass drug administration of antibiotics on the gut microbiota of target populations |
| title_fullStr | The impact of mass drug administration of antibiotics on the gut microbiota of target populations |
| title_full_unstemmed | The impact of mass drug administration of antibiotics on the gut microbiota of target populations |
| title_short | The impact of mass drug administration of antibiotics on the gut microbiota of target populations |
| title_sort | impact of mass drug administration of antibiotics on the gut microbiota of target populations |
| topic | Antibiotics Mass drug administration Microbiota Microbiome |
| url | https://doi.org/10.1186/s40249-022-00999-5 |
| work_keys_str_mv | AT ethankgough theimpactofmassdrugadministrationofantibioticsonthegutmicrobiotaoftargetpopulations AT ethankgough impactofmassdrugadministrationofantibioticsonthegutmicrobiotaoftargetpopulations |