The SARS-CoV-2 Antibodies, Their Diagnostic Utility, and Their Potential for Vaccine Development
Antibodies (Abs) are important immune mediators and powerful diagnostic markers in a wide range of infectious diseases. Understanding the humoral immunity or the development of effective antibodies against SARS-CoV-2 is a prerequisite for limiting disease burden in the community and aids in the deve...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/8/1346 |
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| author | Khalid Hajissa Ali Mussa Mohmed Isaqali Karobari Muhammad Adamu Abbas Ibrahim Khider Ibrahim Ali A Assiry Azhar Iqbal Saad Alhumaid Abbas Al Mutair Ali A. Rabaan Pietro Messina Giuseppe Alessandro Scardina |
| author_facet | Khalid Hajissa Ali Mussa Mohmed Isaqali Karobari Muhammad Adamu Abbas Ibrahim Khider Ibrahim Ali A Assiry Azhar Iqbal Saad Alhumaid Abbas Al Mutair Ali A. Rabaan Pietro Messina Giuseppe Alessandro Scardina |
| author_sort | Khalid Hajissa |
| collection | DOAJ |
| description | Antibodies (Abs) are important immune mediators and powerful diagnostic markers in a wide range of infectious diseases. Understanding the humoral immunity or the development of effective antibodies against SARS-CoV-2 is a prerequisite for limiting disease burden in the community and aids in the development of new diagnostic, therapeutic, and vaccination options. Accordingly, the role of antiviral antibodies in the resistance to and diagnosis of SARS-CoV-2 infection was explored. Antibody testing showed the potential in adding important diagnostic value to the routine diagnosis and clinical management of COVID-19. They could also play a critical role in COVID-19 surveillance, allowing for a better understanding of the full scope of the disease. The development of several vaccines and the success of passive immunotherapy suggest that anti-SARS-CoV-2 antibodies have the potential to be used in the treatment and prevention of SARS-CoV-2 infection. In this review, we highlight the role of antibodies in the diagnosis of SARS-CoV-2 infection and provide an update on their protective roles in controlling SARS-CoV-2 infection as well as vaccine development. |
| first_indexed | 2024-03-09T12:23:39Z |
| format | Article |
| id | doaj.art-5b24d83d2f974306b8463145f7211027 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T12:23:39Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-5b24d83d2f974306b8463145f72110272023-11-30T22:37:43ZengMDPI AGVaccines2076-393X2022-08-01108134610.3390/vaccines10081346The SARS-CoV-2 Antibodies, Their Diagnostic Utility, and Their Potential for Vaccine DevelopmentKhalid Hajissa0Ali Mussa1Mohmed Isaqali Karobari2Muhammad Adamu Abbas3Ibrahim Khider Ibrahim4Ali A Assiry5Azhar Iqbal6Saad Alhumaid7Abbas Al Mutair8Ali A. Rabaan9Pietro Messina10Giuseppe Alessandro Scardina11Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, MalaysiaDepartment of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, MalaysiaConservative Dentistry Unit, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kota Bharu 16150, Kelantan, MalaysiaDepartment of Medical Microbiology and Parasitology, College of Health Sciences, Bayero University Kano, Kano 3011, NigeriaDepartment of Haematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum 11111, SudanPreventive Dental Science Department, Faculty of Dentistry, Najran University, Najran 55461, Saudi ArabiaDepartment of Restorative Dentistry, College of Dentistry, Jouf University, Sakaka 72345, Saudi ArabiaAdministration of Pharmaceutical Care, Al-Ahsa Health Cluster, Ministry of Health, Al-Ahsa 31982, Saudi ArabiaResearch Center, Almoosa Specialist Hospital, Al-Ahsa 36342, Saudi ArabiaMolecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi ArabiaDepartment of Surgical, Oncological and Stomatological Disciplines, University of Palermo, 90133 Palermo, ItalyDepartment of Surgical, Oncological and Stomatological Disciplines, University of Palermo, 90133 Palermo, ItalyAntibodies (Abs) are important immune mediators and powerful diagnostic markers in a wide range of infectious diseases. Understanding the humoral immunity or the development of effective antibodies against SARS-CoV-2 is a prerequisite for limiting disease burden in the community and aids in the development of new diagnostic, therapeutic, and vaccination options. Accordingly, the role of antiviral antibodies in the resistance to and diagnosis of SARS-CoV-2 infection was explored. Antibody testing showed the potential in adding important diagnostic value to the routine diagnosis and clinical management of COVID-19. They could also play a critical role in COVID-19 surveillance, allowing for a better understanding of the full scope of the disease. The development of several vaccines and the success of passive immunotherapy suggest that anti-SARS-CoV-2 antibodies have the potential to be used in the treatment and prevention of SARS-CoV-2 infection. In this review, we highlight the role of antibodies in the diagnosis of SARS-CoV-2 infection and provide an update on their protective roles in controlling SARS-CoV-2 infection as well as vaccine development.https://www.mdpi.com/2076-393X/10/8/1346COVID-19SARS-CoV-2antibodiestestingserodiagnosticimmunotherapy |
| spellingShingle | Khalid Hajissa Ali Mussa Mohmed Isaqali Karobari Muhammad Adamu Abbas Ibrahim Khider Ibrahim Ali A Assiry Azhar Iqbal Saad Alhumaid Abbas Al Mutair Ali A. Rabaan Pietro Messina Giuseppe Alessandro Scardina The SARS-CoV-2 Antibodies, Their Diagnostic Utility, and Their Potential for Vaccine Development Vaccines COVID-19 SARS-CoV-2 antibodies testing serodiagnostic immunotherapy |
| title | The SARS-CoV-2 Antibodies, Their Diagnostic Utility, and Their Potential for Vaccine Development |
| title_full | The SARS-CoV-2 Antibodies, Their Diagnostic Utility, and Their Potential for Vaccine Development |
| title_fullStr | The SARS-CoV-2 Antibodies, Their Diagnostic Utility, and Their Potential for Vaccine Development |
| title_full_unstemmed | The SARS-CoV-2 Antibodies, Their Diagnostic Utility, and Their Potential for Vaccine Development |
| title_short | The SARS-CoV-2 Antibodies, Their Diagnostic Utility, and Their Potential for Vaccine Development |
| title_sort | sars cov 2 antibodies their diagnostic utility and their potential for vaccine development |
| topic | COVID-19 SARS-CoV-2 antibodies testing serodiagnostic immunotherapy |
| url | https://www.mdpi.com/2076-393X/10/8/1346 |
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