microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
Autosomal dominant polycystic kidney disease (ADPKD) is a life-threatening genetic disease that leads to renal failure. Here Hajarniset al. show that miR-17 modulates cyst progression in ADPKD through metabolic reprogramming of mitochondria and its inhibition slows cyst development and improves rena...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14395 |
| _version_ | 1818977631056429056 |
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| author | Sachin Hajarnis Ronak Lakhia Matanel Yheskel Darren Williams Mehran Sorourian Xueqing Liu Karam Aboudehen Shanrong Zhang Kara Kersjes Ryan Galasso Jian Li Vivek Kaimal Steven Lockton Scott Davis Andrea Flaten Joshua A. Johnson William L. Holland Christine M. Kusminski Philipp E. Scherer Peter C. Harris Marie Trudel Darren P. Wallace Peter Igarashi Edmund C. Lee John R. Androsavich Vishal Patel |
| author_facet | Sachin Hajarnis Ronak Lakhia Matanel Yheskel Darren Williams Mehran Sorourian Xueqing Liu Karam Aboudehen Shanrong Zhang Kara Kersjes Ryan Galasso Jian Li Vivek Kaimal Steven Lockton Scott Davis Andrea Flaten Joshua A. Johnson William L. Holland Christine M. Kusminski Philipp E. Scherer Peter C. Harris Marie Trudel Darren P. Wallace Peter Igarashi Edmund C. Lee John R. Androsavich Vishal Patel |
| author_sort | Sachin Hajarnis |
| collection | DOAJ |
| description | Autosomal dominant polycystic kidney disease (ADPKD) is a life-threatening genetic disease that leads to renal failure. Here Hajarniset al. show that miR-17 modulates cyst progression in ADPKD through metabolic reprogramming of mitochondria and its inhibition slows cyst development and improves renal functions. |
| first_indexed | 2024-12-20T16:30:48Z |
| format | Article |
| id | doaj.art-5b2531a29caa4303ae532695340657ca |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:30:48Z |
| publishDate | 2017-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5b2531a29caa4303ae532695340657ca2022-12-21T19:33:16ZengNature PortfolioNature Communications2041-17232017-02-018111510.1038/ncomms14395microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolismSachin Hajarnis0Ronak Lakhia1Matanel Yheskel2Darren Williams3Mehran Sorourian4Xueqing Liu5Karam Aboudehen6Shanrong Zhang7Kara Kersjes8Ryan Galasso9Jian Li10Vivek Kaimal11Steven Lockton12Scott Davis13Andrea Flaten14Joshua A. Johnson15William L. Holland16Christine M. Kusminski17Philipp E. Scherer18Peter C. Harris19Marie Trudel20Darren P. Wallace21Peter Igarashi22Edmund C. Lee23John R. Androsavich24Vishal Patel25Department of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical CenterDepartment of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical CenterDepartment of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical CenterDepartment of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical CenterRegulus Therapeutics Inc.Regulus Therapeutics Inc.Department of Medicine and Division of Nephrology, University of Minnesota Medical SchoolAdvanced Imaging Research Center, University of Texas Southwestern Medical CenterRegulus Therapeutics Inc.Regulus Therapeutics Inc.Regulus Therapeutics Inc.Regulus Therapeutics Inc.Regulus Therapeutics Inc.Regulus Therapeutics Inc.Department of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical CenterDepartment of Internal Medicine and Touchstone Diabetes Center, University of Texas Southwestern Medical CenterDepartment of Internal Medicine and Touchstone Diabetes Center, University of Texas Southwestern Medical CenterDepartment of Internal Medicine and Touchstone Diabetes Center, University of Texas Southwestern Medical CenterDepartment of Internal Medicine and Touchstone Diabetes Center, University of Texas Southwestern Medical CenterDepartment of Nephrology and Hypertension, Mayo College of MedicineMolecular Genetics and Development, Institut de Recherches Cliniques de Montreal, Universite de Montreal, Faculte de MedecineDepartment of Medicine and the Kidney Institute, University of Kansas Medical CenterDepartment of Medicine and Division of Nephrology, University of Minnesota Medical SchoolRegulus Therapeutics Inc.Regulus Therapeutics Inc.Department of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical CenterAutosomal dominant polycystic kidney disease (ADPKD) is a life-threatening genetic disease that leads to renal failure. Here Hajarniset al. show that miR-17 modulates cyst progression in ADPKD through metabolic reprogramming of mitochondria and its inhibition slows cyst development and improves renal functions.https://doi.org/10.1038/ncomms14395 |
| spellingShingle | Sachin Hajarnis Ronak Lakhia Matanel Yheskel Darren Williams Mehran Sorourian Xueqing Liu Karam Aboudehen Shanrong Zhang Kara Kersjes Ryan Galasso Jian Li Vivek Kaimal Steven Lockton Scott Davis Andrea Flaten Joshua A. Johnson William L. Holland Christine M. Kusminski Philipp E. Scherer Peter C. Harris Marie Trudel Darren P. Wallace Peter Igarashi Edmund C. Lee John R. Androsavich Vishal Patel microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism Nature Communications |
| title | microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism |
| title_full | microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism |
| title_fullStr | microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism |
| title_full_unstemmed | microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism |
| title_short | microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism |
| title_sort | microrna 17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism |
| url | https://doi.org/10.1038/ncomms14395 |
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