IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis

IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis

Summary: Group 3 innate lymphoid cells (ILC3s) are vital for defending tissue barriers from invading pathogens. Hypoxia influences the production of intestinal ILC3-derived cytokines by activating HIF. Yet, the mechanisms governing HIF-1α in ILC3s and other innate RORγt+ cells during in vivo infecti...

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Bibliographic Details
Main Authors: Ana Valle-Noguera, Lucía Sancho-Temiño, Raquel Castillo-González, Cristina Villa-Gómez, María José Gomez-Sánchez, Anne Ochoa-Ramos, Patricia Yagüe-Fernández, Blanca Soler Palacios, Virginia Zorita, Berta Raposo-Ponce, José María González-Granado, Julián Aragonés, Aránzazu Cruz-Adalia
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723015206

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