Prognostic value of lncRNA AFAP1‐AS1 in breast cancer: a meta‐analysis and validated study in Chinese population
Abstract Background Long non encoding RNA (lncRNA) plays a crucial role in breast cancer. However, the prognostic role of AFAP1‐AS1 in breast cancer remains unclear. Aims To investigate the relationship between the expression of long non‐coding RNA actin filament‐associated protein1 antisense RNA1 (...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.1923 |
| _version_ | 1827372929338310656 |
|---|---|
| author | Zhenxing Yang Tao Huang Chong Sheng Kaijuan Wang Yilin Li Yajing Feng Dandan Huo Fujiao Duan |
| author_facet | Zhenxing Yang Tao Huang Chong Sheng Kaijuan Wang Yilin Li Yajing Feng Dandan Huo Fujiao Duan |
| author_sort | Zhenxing Yang |
| collection | DOAJ |
| description | Abstract Background Long non encoding RNA (lncRNA) plays a crucial role in breast cancer. However, the prognostic role of AFAP1‐AS1 in breast cancer remains unclear. Aims To investigate the relationship between the expression of long non‐coding RNA actin filament‐associated protein1 antisense RNA1 (AFAP1‐AS1) and prognosis of breast cancer. Methods and Results Meta‐analysis was performed to explore the correlation between AFAP1‐AS1 and breast cancer. The AFAP1‐AS1expression in patients with breast cancer tissue and adjacent normal tissue from 153 patients was determined by qRT‐PCR. Bioinformatics and Cox proportional‐hazards risk model were used to explore the relationship between expression of AFAP1‐AS1 and prognosis. The combined analysis revealed a significant correlation between AFAP1‐AS1 expression and both overall survival (hazard ratios, HR = 2.33, 95%Cl: 1.94–2.81, p < 0.001) as well as disease‐free survival/progression‐free survival (HR = 2.94, 95%CI: 2.35–3.67, p < 0.001). The relation between expression of AFAP1‐AS1 and breast cancer was determined in 153 breast cancer and adjacent normal tissues. The findings revealed a significantly higher AFAP1‐AS1expression levels in breast cancer tissues compared to adjacent normal tissues (p < 0.001). Additionally, patients exhibiting heightened levels of AFAP1‐AS1 expression were correlated with an unfavorable prognosis (HR = 2.35, 95%CI: 1.47–3.74, p < 0.001), which aligns consistently with the findings of the pooled analysis. The subgroup analysis of clinical characteristics revealed a significant association between high expression of AFAP1‐AS1 and TNM stage (HR = 1.72, 95%CI: 1.11–2.65, p = 0.015). Conclusion This study demonstrated that AFAP1‐AS1 acts as an oncogene and may serve as a novel prognostic marker for breast cancer, particularly in the Chinese population. |
| first_indexed | 2024-03-08T11:08:24Z |
| format | Article |
| id | doaj.art-5b2649376132439bb2bc129954ac8435 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-03-08T11:08:24Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-5b2649376132439bb2bc129954ac84352024-01-26T14:25:02ZengWileyCancer Reports2573-83482024-01-0171n/an/a10.1002/cnr2.1923Prognostic value of lncRNA AFAP1‐AS1 in breast cancer: a meta‐analysis and validated study in Chinese populationZhenxing Yang0Tao Huang1Chong Sheng2Kaijuan Wang3Yilin Li4Yajing Feng5Dandan Huo6Fujiao Duan7Department of Medical Research Office the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital Zhengzhou ChinaDepartment of Medical Research Office the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital Zhengzhou ChinaCollege of Public Health Zhengzhou University Zhengzhou ChinaCollege of Public Health Zhengzhou University Zhengzhou ChinaDepartment of Medical Research Office the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital Zhengzhou ChinaDepartment of Hospital Infection Management the First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Medical Research Office the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital Zhengzhou ChinaDepartment of Medical Research Office the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital Zhengzhou ChinaAbstract Background Long non encoding RNA (lncRNA) plays a crucial role in breast cancer. However, the prognostic role of AFAP1‐AS1 in breast cancer remains unclear. Aims To investigate the relationship between the expression of long non‐coding RNA actin filament‐associated protein1 antisense RNA1 (AFAP1‐AS1) and prognosis of breast cancer. Methods and Results Meta‐analysis was performed to explore the correlation between AFAP1‐AS1 and breast cancer. The AFAP1‐AS1expression in patients with breast cancer tissue and adjacent normal tissue from 153 patients was determined by qRT‐PCR. Bioinformatics and Cox proportional‐hazards risk model were used to explore the relationship between expression of AFAP1‐AS1 and prognosis. The combined analysis revealed a significant correlation between AFAP1‐AS1 expression and both overall survival (hazard ratios, HR = 2.33, 95%Cl: 1.94–2.81, p < 0.001) as well as disease‐free survival/progression‐free survival (HR = 2.94, 95%CI: 2.35–3.67, p < 0.001). The relation between expression of AFAP1‐AS1 and breast cancer was determined in 153 breast cancer and adjacent normal tissues. The findings revealed a significantly higher AFAP1‐AS1expression levels in breast cancer tissues compared to adjacent normal tissues (p < 0.001). Additionally, patients exhibiting heightened levels of AFAP1‐AS1 expression were correlated with an unfavorable prognosis (HR = 2.35, 95%CI: 1.47–3.74, p < 0.001), which aligns consistently with the findings of the pooled analysis. The subgroup analysis of clinical characteristics revealed a significant association between high expression of AFAP1‐AS1 and TNM stage (HR = 1.72, 95%CI: 1.11–2.65, p = 0.015). Conclusion This study demonstrated that AFAP1‐AS1 acts as an oncogene and may serve as a novel prognostic marker for breast cancer, particularly in the Chinese population.https://doi.org/10.1002/cnr2.1923breast cancerlncRNA AFAP1‐AS1prognosissystem evaluation |
| spellingShingle | Zhenxing Yang Tao Huang Chong Sheng Kaijuan Wang Yilin Li Yajing Feng Dandan Huo Fujiao Duan Prognostic value of lncRNA AFAP1‐AS1 in breast cancer: a meta‐analysis and validated study in Chinese population Cancer Reports breast cancer lncRNA AFAP1‐AS1 prognosis system evaluation |
| title | Prognostic value of lncRNA AFAP1‐AS1 in breast cancer: a meta‐analysis and validated study in Chinese population |
| title_full | Prognostic value of lncRNA AFAP1‐AS1 in breast cancer: a meta‐analysis and validated study in Chinese population |
| title_fullStr | Prognostic value of lncRNA AFAP1‐AS1 in breast cancer: a meta‐analysis and validated study in Chinese population |
| title_full_unstemmed | Prognostic value of lncRNA AFAP1‐AS1 in breast cancer: a meta‐analysis and validated study in Chinese population |
| title_short | Prognostic value of lncRNA AFAP1‐AS1 in breast cancer: a meta‐analysis and validated study in Chinese population |
| title_sort | prognostic value of lncrna afap1 as1 in breast cancer a meta analysis and validated study in chinese population |
| topic | breast cancer lncRNA AFAP1‐AS1 prognosis system evaluation |
| url | https://doi.org/10.1002/cnr2.1923 |
| work_keys_str_mv | AT zhenxingyang prognosticvalueoflncrnaafap1as1inbreastcancerametaanalysisandvalidatedstudyinchinesepopulation AT taohuang prognosticvalueoflncrnaafap1as1inbreastcancerametaanalysisandvalidatedstudyinchinesepopulation AT chongsheng prognosticvalueoflncrnaafap1as1inbreastcancerametaanalysisandvalidatedstudyinchinesepopulation AT kaijuanwang prognosticvalueoflncrnaafap1as1inbreastcancerametaanalysisandvalidatedstudyinchinesepopulation AT yilinli prognosticvalueoflncrnaafap1as1inbreastcancerametaanalysisandvalidatedstudyinchinesepopulation AT yajingfeng prognosticvalueoflncrnaafap1as1inbreastcancerametaanalysisandvalidatedstudyinchinesepopulation AT dandanhuo prognosticvalueoflncrnaafap1as1inbreastcancerametaanalysisandvalidatedstudyinchinesepopulation AT fujiaoduan prognosticvalueoflncrnaafap1as1inbreastcancerametaanalysisandvalidatedstudyinchinesepopulation |