Vedolizumab blocks α4β7 integrin-mediated T cell adhesion to MAdCAM-1 in microscopic colitis
Background: In Crohn’s disease and ulcerative colitis, the anti-α4β7 integrin antibody vedolizumab has demonstrated efficacy in phase III trials and has been successfully used under real-world conditions. Occasionally, it has also been used in other forms of inflammatory bowel disease (IBD) such as...
Main Authors: | Laura Besendorf, Tanja M. Müller, Carol-Immanuel Geppert, Ines Schneider, Laura Mühl, Imke Atreya, Francesco Vitali, Raja Atreya, Markus F. Neurath, Sebastian Zundler |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2022-06-01
|
Series: | Therapeutic Advances in Gastroenterology |
Online Access: | https://doi.org/10.1177/17562848221098899 |
Similar Items
-
Baseline levels of dynamic CD4+ T cell adhesion to MAdCAM-1 correlate with clinical response to vedolizumab treatment in ulcerative colitis: a cohort study
by: Clarissa Allner, et al.
Published: (2020-04-01) -
Clinical Response to Vedolizumab in Ulcerative Colitis Patients Is Associated with Changes in Integrin Expression Profiles
by: Friederike Fuchs, et al.
Published: (2017-07-01) -
Clinical experiences and predictors of success of treatment with vedolizumab in IBD patients: a cohort study
by: Laura Mühl, et al.
Published: (2021-01-01) -
The Force-Dependent Mechanism of an Integrin α4β7–MAdCAM-1 Interaction
by: Youmin Su, et al.
Published: (2023-11-01) -
Alpha4 integrin binding interfaces on VCAM-1 and MAdCAM-1. Integrin binding footprints identify accessory binding sites that play a role in integrin specificity.
by: Newham, P, et al.
Published: (1997)