WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response

WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response

Abstract RIG-I-MAVS signaling pathway plays a crucial role in defending against pathogen infection and maintaining immune balance. Upon detecting viral RNA, RIG-I triggers the formation of prion-like aggregates of the adaptor protein MAVS, which then activates the innate antiviral immune response. H...

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Bibliographic Details
Main Authors: Jiaxin Li, Rui Zhang, Changwan Wang, Junyan Zhu, Miao Ren, Yingbo Jiang, Xianteng Hou, Yangting Du, Qing Wu, Shishi Qi, Lin Li, She Chen, Hui Yang, Fajian Hou
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40567-5

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