Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis
Abstract Background Late‐life aging is often associated with appetite reduction and weight loss. Physical activity (PA) may prevent these processes, but the molecular mechanisms involved remain elusive. The present study investigated the putative mediating aspect of growth differentiation factor 15...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-04-01
|
| Series: | Journal of Cachexia, Sarcopenia and Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcsm.13152 |
| _version_ | 1797854132343668736 |
|---|---|
| author | Jérémy Raffin Yves Rolland Angelo Parini Alexandre Lucas Sophie Guyonnet Bruno Vellas Philipe deSouto Barreto For the MAPT/DSA Group |
| author_facet | Jérémy Raffin Yves Rolland Angelo Parini Alexandre Lucas Sophie Guyonnet Bruno Vellas Philipe deSouto Barreto For the MAPT/DSA Group |
| author_sort | Jérémy Raffin |
| collection | DOAJ |
| description | Abstract Background Late‐life aging is often associated with appetite reduction and weight loss. Physical activity (PA) may prevent these processes, but the molecular mechanisms involved remain elusive. The present study investigated the putative mediating aspect of growth differentiation factor 15 (GDF‐15), a stress signalling protein involved in aging, exercise and appetite control, on the association between PA and late‐life‐associated weight loss. Methods One thousand eighty‐three healthy adults (63.8% women) aged 70 years and over who participated in the Multidomain Alzheimer Preventive Trial were included. Bodyweight (kg) and PA levels (square root of metabolic equivalent of task‐min/week) were assessed repeatedly from baseline to the 3‐year visit, whereas plasma GDF‐15 (pg/mL) was measured at the 1‐year visit. Multiple linear regressions were performed to test the association between first‐year mean PA level, 1‐year visit GDF‐15 concentration and subsequent bodyweight changes. Mediation analyses were used to investigate whether GDF‐15 mediated the association between first‐year mean PA levels and consecutive bodyweight changes. Results Multiple regression analyses demonstrated that higher first‐year mean PA levels significantly predicted lower GDF‐15 and bodyweight at 1 year (B = −2.22; SE = 0.79; P = 0.005). In addition, higher 1‐year visit GDF‐15 levels were associated with faster subsequent bodyweight loss (Time × GDF‐15 interaction B = −0.0004; SE = 0.0001; P = 0.003). Mediation analyses confirmed that GDF‐15 mediated the association between first‐year mean PA levels and subsequent bodyweight changes (mediated effect ab = 0.0018; bootstrap SE = 0.001; P < 0.05) and revealed that mean PA had no direct effect on subsequent bodyweight changes (c′ = 0.006; SE = 0.008; P > 0.05). Conclusions This study suggests that GDF‐15 may be one of the molecules mediating the link between PA and late‐life weight loss, but mechanistic studies are necessary to further support the present findings. |
| first_indexed | 2024-04-09T20:01:57Z |
| format | Article |
| id | doaj.art-5b27530bf2b24107b7b69d118ce29d2e |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2024-04-09T20:01:57Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-5b27530bf2b24107b7b69d118ce29d2e2023-04-03T02:38:50ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092023-04-0114277178010.1002/jcsm.13152Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysisJérémy Raffin0Yves Rolland1Angelo Parini2Alexandre Lucas3Sophie Guyonnet4Bruno Vellas5Philipe deSouto Barreto6For the MAPT/DSA GroupGérontopôle de Toulouse, Institut du Vieillissement Centre Hospitalo‐Universitaire de Toulouse Toulouse FranceGérontopôle de Toulouse, Institut du Vieillissement Centre Hospitalo‐Universitaire de Toulouse Toulouse FranceInstitute of Metabolic and Cardiovascular Diseases, UMR1048 Toulouse Cedex 4 FranceInstitute of Metabolic and Cardiovascular Diseases, UMR1048 Toulouse Cedex 4 FranceGérontopôle de Toulouse, Institut du Vieillissement Centre Hospitalo‐Universitaire de Toulouse Toulouse FranceGérontopôle de Toulouse, Institut du Vieillissement Centre Hospitalo‐Universitaire de Toulouse Toulouse FranceGérontopôle de Toulouse, Institut du Vieillissement Centre Hospitalo‐Universitaire de Toulouse Toulouse FranceAbstract Background Late‐life aging is often associated with appetite reduction and weight loss. Physical activity (PA) may prevent these processes, but the molecular mechanisms involved remain elusive. The present study investigated the putative mediating aspect of growth differentiation factor 15 (GDF‐15), a stress signalling protein involved in aging, exercise and appetite control, on the association between PA and late‐life‐associated weight loss. Methods One thousand eighty‐three healthy adults (63.8% women) aged 70 years and over who participated in the Multidomain Alzheimer Preventive Trial were included. Bodyweight (kg) and PA levels (square root of metabolic equivalent of task‐min/week) were assessed repeatedly from baseline to the 3‐year visit, whereas plasma GDF‐15 (pg/mL) was measured at the 1‐year visit. Multiple linear regressions were performed to test the association between first‐year mean PA level, 1‐year visit GDF‐15 concentration and subsequent bodyweight changes. Mediation analyses were used to investigate whether GDF‐15 mediated the association between first‐year mean PA levels and consecutive bodyweight changes. Results Multiple regression analyses demonstrated that higher first‐year mean PA levels significantly predicted lower GDF‐15 and bodyweight at 1 year (B = −2.22; SE = 0.79; P = 0.005). In addition, higher 1‐year visit GDF‐15 levels were associated with faster subsequent bodyweight loss (Time × GDF‐15 interaction B = −0.0004; SE = 0.0001; P = 0.003). Mediation analyses confirmed that GDF‐15 mediated the association between first‐year mean PA levels and subsequent bodyweight changes (mediated effect ab = 0.0018; bootstrap SE = 0.001; P < 0.05) and revealed that mean PA had no direct effect on subsequent bodyweight changes (c′ = 0.006; SE = 0.008; P > 0.05). Conclusions This study suggests that GDF‐15 may be one of the molecules mediating the link between PA and late‐life weight loss, but mechanistic studies are necessary to further support the present findings.https://doi.org/10.1002/jcsm.13152agingGDF‐15, physical activity, weight lossolder adults |
| spellingShingle | Jérémy Raffin Yves Rolland Angelo Parini Alexandre Lucas Sophie Guyonnet Bruno Vellas Philipe deSouto Barreto For the MAPT/DSA Group Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis Journal of Cachexia, Sarcopenia and Muscle aging GDF‐15, physical activity, weight loss older adults |
| title | Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis |
| title_full | Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis |
| title_fullStr | Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis |
| title_full_unstemmed | Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis |
| title_short | Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis |
| title_sort | association between physical activity growth differentiation factor 15 and bodyweight in older adults a longitudinal mediation analysis |
| topic | aging GDF‐15, physical activity, weight loss older adults |
| url | https://doi.org/10.1002/jcsm.13152 |
| work_keys_str_mv | AT jeremyraffin associationbetweenphysicalactivitygrowthdifferentiationfactor15andbodyweightinolderadultsalongitudinalmediationanalysis AT yvesrolland associationbetweenphysicalactivitygrowthdifferentiationfactor15andbodyweightinolderadultsalongitudinalmediationanalysis AT angeloparini associationbetweenphysicalactivitygrowthdifferentiationfactor15andbodyweightinolderadultsalongitudinalmediationanalysis AT alexandrelucas associationbetweenphysicalactivitygrowthdifferentiationfactor15andbodyweightinolderadultsalongitudinalmediationanalysis AT sophieguyonnet associationbetweenphysicalactivitygrowthdifferentiationfactor15andbodyweightinolderadultsalongitudinalmediationanalysis AT brunovellas associationbetweenphysicalactivitygrowthdifferentiationfactor15andbodyweightinolderadultsalongitudinalmediationanalysis AT philipedesoutobarreto associationbetweenphysicalactivitygrowthdifferentiationfactor15andbodyweightinolderadultsalongitudinalmediationanalysis AT forthemaptdsagroup associationbetweenphysicalactivitygrowthdifferentiationfactor15andbodyweightinolderadultsalongitudinalmediationanalysis |