Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6

Abstract Background Metformin, a type 2 diabetes treatment, improves the cognitive function of aged mice; however, whether the protective effects of metformin on cognitive function in aged mice are associated with the gut microbiome is poorly understood. Although some studies suggest that the gut mi...

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Bibliographic Details
Main Authors: Xiaoqi Zhu, Junyan Shen, Shengyu Feng, Ce Huang, Hao Wang, Fengjiao Huo, Hailiang Liu
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Microbiome
Subjects:
Online Access:https://doi.org/10.1186/s40168-023-01567-1