Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice
For the first time, the complexation of pentacyclic triterpenes of licorice (glycyrrhizic acid (GA) and its aglycone, glycyrrhetinic acid (GLA)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using both UV/Vis...
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Format: | Article |
Language: | English |
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Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina
2020-12-01
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Series: | Chimica Techno Acta |
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Online Access: | https://journals.urfu.ru/index.php/chimtech/article/view/4808 |
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author | S. S. Khizrieva E. V. Vetrova S. N. Borisenko E. V. Maksimenko N. I. Borisenko |
author_facet | S. S. Khizrieva E. V. Vetrova S. N. Borisenko E. V. Maksimenko N. I. Borisenko |
author_sort | S. S. Khizrieva |
collection | DOAJ |
description | For the first time, the complexation of pentacyclic triterpenes of licorice (glycyrrhizic acid (GA) and its aglycone, glycyrrhetinic acid (GLA)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using both UV/Vis spectroscopy and mass spectrometry (ESI MS). Formation of the host:guest complexes were registered: GA and GLA molecular complexes (Camph+2GA; Camph+2GLA) with stability constants К = 6.94 106 М-2 and К = 2.89 106 М-2, respectively. The research results demonstrate a considerable potential of ESI MS as a technique for simple and fast detection of formation of the complexes of GA /GLA and the novel drugs. |
first_indexed | 2024-12-20T22:24:52Z |
format | Article |
id | doaj.art-5b299b1f8736402aaf452d0385aad908 |
institution | Directory Open Access Journal |
issn | 2411-1414 |
language | English |
last_indexed | 2024-12-20T22:24:52Z |
publishDate | 2020-12-01 |
publisher | Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina |
record_format | Article |
series | Chimica Techno Acta |
spelling | doaj.art-5b299b1f8736402aaf452d0385aad9082022-12-21T19:24:50ZengUralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. ElʹcinaChimica Techno Acta2411-14142020-12-017419219810.15826/chimtech.2020.7.4.103711Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licoriceS. S. Khizrieva0E. V. Vetrova1S. N. Borisenko2E. V. Maksimenko3N. I. Borisenko4Southern Federal University, Rostov-on-DonSouthern Federal University, Rostov-on-DonSouthern Federal University, Rostov-on-DonSouthern Federal University, Rostov-on-DonSouthern Federal University, Rostov-on-DonFor the first time, the complexation of pentacyclic triterpenes of licorice (glycyrrhizic acid (GA) and its aglycone, glycyrrhetinic acid (GLA)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using both UV/Vis spectroscopy and mass spectrometry (ESI MS). Formation of the host:guest complexes were registered: GA and GLA molecular complexes (Camph+2GA; Camph+2GLA) with stability constants К = 6.94 106 М-2 and К = 2.89 106 М-2, respectively. The research results demonstrate a considerable potential of ESI MS as a technique for simple and fast detection of formation of the complexes of GA /GLA and the novel drugs.https://journals.urfu.ru/index.php/chimtech/article/view/4808campheceneglycyrrhizic acidglycyrrhetinic acidantiviral activitysupramolecular complexes |
spellingShingle | S. S. Khizrieva E. V. Vetrova S. N. Borisenko E. V. Maksimenko N. I. Borisenko Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice Chimica Techno Acta camphecene glycyrrhizic acid glycyrrhetinic acid antiviral activity supramolecular complexes |
title | Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice |
title_full | Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice |
title_fullStr | Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice |
title_full_unstemmed | Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice |
title_short | Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice |
title_sort | synthesis and study of complexes of the novel russian antiviral drug camphecene with pentacyclic triterpenes of licorice |
topic | camphecene glycyrrhizic acid glycyrrhetinic acid antiviral activity supramolecular complexes |
url | https://journals.urfu.ru/index.php/chimtech/article/view/4808 |
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