Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice

For the first time, the complexation of pentacyclic triterpenes of licorice (glycyrrhizic acid (GA) and its aglycone, glycyrrhetinic acid (GLA)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using both UV/Vis...

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Main Authors: S. S. Khizrieva, E. V. Vetrova, S. N. Borisenko, E. V. Maksimenko, N. I. Borisenko
Format: Article
Language:English
Published: Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina 2020-12-01
Series:Chimica Techno Acta
Subjects:
Online Access:https://journals.urfu.ru/index.php/chimtech/article/view/4808
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author S. S. Khizrieva
E. V. Vetrova
S. N. Borisenko
E. V. Maksimenko
N. I. Borisenko
author_facet S. S. Khizrieva
E. V. Vetrova
S. N. Borisenko
E. V. Maksimenko
N. I. Borisenko
author_sort S. S. Khizrieva
collection DOAJ
description For the first time, the complexation of pentacyclic triterpenes of licorice (glycyrrhizic acid (GA) and its aglycone, glycyrrhetinic acid (GLA)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using both UV/Vis spectroscopy and mass spectrometry (ESI MS). Formation of the host:guest complexes were registered: GA and GLA molecular complexes (Camph+2GA; Camph+2GLA) with stability constants К = 6.94 106 М-2 and К = 2.89 106 М-2, respectively. The research results demonstrate a considerable potential of ESI MS as a technique for simple and fast detection of formation of the complexes of GA /GLA and the novel drugs.
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spelling doaj.art-5b299b1f8736402aaf452d0385aad9082022-12-21T19:24:50ZengUralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. ElʹcinaChimica Techno Acta2411-14142020-12-017419219810.15826/chimtech.2020.7.4.103711Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licoriceS. S. Khizrieva0E. V. Vetrova1S. N. Borisenko2E. V. Maksimenko3N. I. Borisenko4Southern Federal University, Rostov-on-DonSouthern Federal University, Rostov-on-DonSouthern Federal University, Rostov-on-DonSouthern Federal University, Rostov-on-DonSouthern Federal University, Rostov-on-DonFor the first time, the complexation of pentacyclic triterpenes of licorice (glycyrrhizic acid (GA) and its aglycone, glycyrrhetinic acid (GLA)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using both UV/Vis spectroscopy and mass spectrometry (ESI MS). Formation of the host:guest complexes were registered: GA and GLA molecular complexes (Camph+2GA; Camph+2GLA) with stability constants К = 6.94 106 М-2 and К = 2.89 106 М-2, respectively. The research results demonstrate a considerable potential of ESI MS as a technique for simple and fast detection of formation of the complexes of GA /GLA and the novel drugs.https://journals.urfu.ru/index.php/chimtech/article/view/4808campheceneglycyrrhizic acidglycyrrhetinic acidantiviral activitysupramolecular complexes
spellingShingle S. S. Khizrieva
E. V. Vetrova
S. N. Borisenko
E. V. Maksimenko
N. I. Borisenko
Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice
Chimica Techno Acta
camphecene
glycyrrhizic acid
glycyrrhetinic acid
antiviral activity
supramolecular complexes
title Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice
title_full Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice
title_fullStr Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice
title_full_unstemmed Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice
title_short Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice
title_sort synthesis and study of complexes of the novel russian antiviral drug camphecene with pentacyclic triterpenes of licorice
topic camphecene
glycyrrhizic acid
glycyrrhetinic acid
antiviral activity
supramolecular complexes
url https://journals.urfu.ru/index.php/chimtech/article/view/4808
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