The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility
OBJECTIVE: This study aimed to determine the frequency of the PROGINS polymorphism in women with endometriosis-associated infertility, in infertile women without endometriosis and in controls. INTRODUCTION: The human progesterone receptor gene has two isoforms that modulate the biological action of...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier España
2010-01-01
|
| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010001100002 |
| _version_ | 1818236342744645632 |
|---|---|
| author | Cristiane Gimenes Bianca Bianco Fernanda Abani Mafra Victor Rosset Denise Maria Christofolini Caio Parente Barbosa |
| author_facet | Cristiane Gimenes Bianca Bianco Fernanda Abani Mafra Victor Rosset Denise Maria Christofolini Caio Parente Barbosa |
| author_sort | Cristiane Gimenes |
| collection | DOAJ |
| description | OBJECTIVE: This study aimed to determine the frequency of the PROGINS polymorphism in women with endometriosis-associated infertility, in infertile women without endometriosis and in controls. INTRODUCTION: The human progesterone receptor gene has two isoforms that modulate the biological action of progesterone: isoform A, which is capable of inhibiting the activation of the estrogen receptors, and isoform B, which has the capacity to activate the estrogen receptors. Several polymorphisms have been described for this gene, among which one stands out: a polymorphism named PROGINS, which has been speculated to be related to the genesis of endometriosis by several studies with conflicting results. METHODS: This was a prospective study that included 148 patients with endometriosis-associated infertility, 50 idiopathic infertile patients and 179 fertile women as controls. The PROGINS polymorphism was studied by PCR. RESULTS: Genotypes P1P1, P1P2 and P2P2 (P2 representing the PROGINS polymorphism) of the progesterone receptor gene presented frequencies of 93.9%, 5.4% and 0.7%, respectively, in the women with endometriosis-associated infertility (p=0.2101, OR=0.51, 95% CI=0.24-1.09); 94.4%, 4.2% and 1.4%, respectively, in the patients with minimal/mild endometriosis (p=0.2725, OR=0.53, 95% CI=0.20-1.43); 93.5%, 6.5% and 0%, respectively, among the patients with moderate/severe endometriosis (p=0.3679, OR=0.49, 95% CI=0.18-1.31); 86.0%, 14.0% and 0%, respectively, in idiopathic infertile women (p=0.8146, OR=1.10, 95% CI=0.46-2.63); and 88.3%, 10.6% and 1.1%, respectively, in the control group. CONCLUSION: The data suggest that PROGINS is not related either to endometriosis-associated infertility or to idiopathic infertility in the population studied. |
| first_indexed | 2024-12-12T12:08:21Z |
| format | Article |
| id | doaj.art-5b29ad0974174c6f89b6f37bef1fbe57 |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-12-12T12:08:21Z |
| publishDate | 2010-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-5b29ad0974174c6f89b6f37bef1fbe572022-12-22T00:24:56ZengElsevier EspañaClinics1807-59321980-53222010-01-0165111073107610.1590/S1807-59322010001100002The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertilityCristiane GimenesBianca BiancoFernanda Abani MafraVictor RossetDenise Maria ChristofoliniCaio Parente BarbosaOBJECTIVE: This study aimed to determine the frequency of the PROGINS polymorphism in women with endometriosis-associated infertility, in infertile women without endometriosis and in controls. INTRODUCTION: The human progesterone receptor gene has two isoforms that modulate the biological action of progesterone: isoform A, which is capable of inhibiting the activation of the estrogen receptors, and isoform B, which has the capacity to activate the estrogen receptors. Several polymorphisms have been described for this gene, among which one stands out: a polymorphism named PROGINS, which has been speculated to be related to the genesis of endometriosis by several studies with conflicting results. METHODS: This was a prospective study that included 148 patients with endometriosis-associated infertility, 50 idiopathic infertile patients and 179 fertile women as controls. The PROGINS polymorphism was studied by PCR. RESULTS: Genotypes P1P1, P1P2 and P2P2 (P2 representing the PROGINS polymorphism) of the progesterone receptor gene presented frequencies of 93.9%, 5.4% and 0.7%, respectively, in the women with endometriosis-associated infertility (p=0.2101, OR=0.51, 95% CI=0.24-1.09); 94.4%, 4.2% and 1.4%, respectively, in the patients with minimal/mild endometriosis (p=0.2725, OR=0.53, 95% CI=0.20-1.43); 93.5%, 6.5% and 0%, respectively, among the patients with moderate/severe endometriosis (p=0.3679, OR=0.49, 95% CI=0.18-1.31); 86.0%, 14.0% and 0%, respectively, in idiopathic infertile women (p=0.8146, OR=1.10, 95% CI=0.46-2.63); and 88.3%, 10.6% and 1.1%, respectively, in the control group. CONCLUSION: The data suggest that PROGINS is not related either to endometriosis-associated infertility or to idiopathic infertility in the population studied.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010001100002endometriosispolymorphismPROGINSprogesterone receptor geneinfertility |
| spellingShingle | Cristiane Gimenes Bianca Bianco Fernanda Abani Mafra Victor Rosset Denise Maria Christofolini Caio Parente Barbosa The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility Clinics endometriosis polymorphism PROGINS progesterone receptor gene infertility |
| title | The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility |
| title_full | The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility |
| title_fullStr | The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility |
| title_full_unstemmed | The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility |
| title_short | The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility |
| title_sort | progins progesterone receptor gene polymorphism is not related to endometriosis associated infertility or to idiopathic infertility |
| topic | endometriosis polymorphism PROGINS progesterone receptor gene infertility |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010001100002 |
| work_keys_str_mv | AT cristianegimenes theproginsprogesteronereceptorgenepolymorphismisnotrelatedtoendometriosisassociatedinfertilityortoidiopathicinfertility AT biancabianco theproginsprogesteronereceptorgenepolymorphismisnotrelatedtoendometriosisassociatedinfertilityortoidiopathicinfertility AT fernandaabanimafra theproginsprogesteronereceptorgenepolymorphismisnotrelatedtoendometriosisassociatedinfertilityortoidiopathicinfertility AT victorrosset theproginsprogesteronereceptorgenepolymorphismisnotrelatedtoendometriosisassociatedinfertilityortoidiopathicinfertility AT denisemariachristofolini theproginsprogesteronereceptorgenepolymorphismisnotrelatedtoendometriosisassociatedinfertilityortoidiopathicinfertility AT caioparentebarbosa theproginsprogesteronereceptorgenepolymorphismisnotrelatedtoendometriosisassociatedinfertilityortoidiopathicinfertility AT cristianegimenes proginsprogesteronereceptorgenepolymorphismisnotrelatedtoendometriosisassociatedinfertilityortoidiopathicinfertility AT biancabianco proginsprogesteronereceptorgenepolymorphismisnotrelatedtoendometriosisassociatedinfertilityortoidiopathicinfertility AT fernandaabanimafra proginsprogesteronereceptorgenepolymorphismisnotrelatedtoendometriosisassociatedinfertilityortoidiopathicinfertility AT victorrosset proginsprogesteronereceptorgenepolymorphismisnotrelatedtoendometriosisassociatedinfertilityortoidiopathicinfertility AT denisemariachristofolini proginsprogesteronereceptorgenepolymorphismisnotrelatedtoendometriosisassociatedinfertilityortoidiopathicinfertility AT caioparentebarbosa proginsprogesteronereceptorgenepolymorphismisnotrelatedtoendometriosisassociatedinfertilityortoidiopathicinfertility |