2-arachidonyl glycerol modulates astrocytic glutamine synthetase via p38 and ERK1/2 pathways

2-arachidonyl glycerol modulates astrocytic glutamine synthetase via p38 and ERK1/2 pathways

Abstract Background The glutamine synthetase (GS), an astrocyte-specific enzyme, is involved in lipopolysaccharide (LPS)-induced inflammation which activates the mitogen-activated protein kinase (MAPK) signaling. Endocannabinoid 2-arachidonyl glycerol (2-AG) has been described to serve as an endogen...

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Bibliographic Details
Main Authors: Shenghong Wang, Hua Zhang, Bin Geng, Qiqi Xie, Wenzhou Li, Yajun Deng, Weidong Shi, Yunyan Pan, Xuewen Kang, Jing Wang
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Neuroinflammation
Subjects:
2-AG
Astrocyte
Glutamine synthetase
MAPK
p38
ERK
Online Access:http://link.springer.com/article/10.1186/s12974-018-1254-x

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