Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children
<p>Abstract</p> <p>Objective</p> <p>The aim of the study was to investigate whether the G-174C polymorphism of the IL-6 gene is related to obesity and the incidence of the metabolic syndrome (MetS) according to IDF definition in children.</p> <p>Materials an...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-12-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | http://www.eurjmedres.com/content/14/S4/196 |
| _version_ | 1818393808421781504 |
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| author | Pyrzak B Wisniewska A Majcher A Popko K Wasik M Demkow U |
| author_facet | Pyrzak B Wisniewska A Majcher A Popko K Wasik M Demkow U |
| author_sort | Pyrzak B |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Objective</p> <p>The aim of the study was to investigate whether the G-174C polymorphism of the IL-6 gene is related to obesity and the incidence of the metabolic syndrome (MetS) according to IDF definition in children.</p> <p>Materials and methods</p> <p>The examined group included 124 obese children with BMI ≥ 2 SDS, and the control group consisted of 56 non-obese children with BMI < 1.0 SDS. Polymorphism identification was performed in total genomic DNA using PCR-RFLP method.</p> <p>Results</p> <p>In the obese children, carriers of C allele in homozygotic and heterozygotic genotypes were more frequent than in the control group. The carriers of C alleles presented with lower thickness of subcutaneous tissue and higher concentrations of HDL-C than the wild type. The incidence of MetS was 33% of the group of obese children. Analysis of the presence of MetS factors showed that there is more frequent MetS in the group with the wild homozygous genotype type.</p> <p>Conclusion</p> <p>Polymorphism 174G > C in the IL-6 gene does not seem to be associated with obesity and with the incidence of MetS in children.</p> |
| first_indexed | 2024-12-14T05:51:12Z |
| format | Article |
| id | doaj.art-5b2ac349d4de43008180b1421b28b59f |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-12-14T05:51:12Z |
| publishDate | 2009-12-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-5b2ac349d4de43008180b1421b28b59f2022-12-21T23:14:43ZengBMCEuropean Journal of Medical Research2047-783X2009-12-0114Suppl 419620010.1186/2047-783X-14-S4-196Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese childrenPyrzak BWisniewska AMajcher APopko KWasik MDemkow U<p>Abstract</p> <p>Objective</p> <p>The aim of the study was to investigate whether the G-174C polymorphism of the IL-6 gene is related to obesity and the incidence of the metabolic syndrome (MetS) according to IDF definition in children.</p> <p>Materials and methods</p> <p>The examined group included 124 obese children with BMI ≥ 2 SDS, and the control group consisted of 56 non-obese children with BMI < 1.0 SDS. Polymorphism identification was performed in total genomic DNA using PCR-RFLP method.</p> <p>Results</p> <p>In the obese children, carriers of C allele in homozygotic and heterozygotic genotypes were more frequent than in the control group. The carriers of C alleles presented with lower thickness of subcutaneous tissue and higher concentrations of HDL-C than the wild type. The incidence of MetS was 33% of the group of obese children. Analysis of the presence of MetS factors showed that there is more frequent MetS in the group with the wild homozygous genotype type.</p> <p>Conclusion</p> <p>Polymorphism 174G > C in the IL-6 gene does not seem to be associated with obesity and with the incidence of MetS in children.</p>http://www.eurjmedres.com/content/14/S4/196interleukin-6polymorphismobesitychildrenmetabolic syndrome |
| spellingShingle | Pyrzak B Wisniewska A Majcher A Popko K Wasik M Demkow U Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children European Journal of Medical Research interleukin-6 polymorphism obesity children metabolic syndrome |
| title | Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children |
| title_full | Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children |
| title_fullStr | Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children |
| title_full_unstemmed | Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children |
| title_short | Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children |
| title_sort | association between metabolic disturbances and g 174c polymorphism of interleukin 6 gene in obese children |
| topic | interleukin-6 polymorphism obesity children metabolic syndrome |
| url | http://www.eurjmedres.com/content/14/S4/196 |
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