Pneumococcal pneumonia and the risk of stroke: a population-based follow-up study.
BACKGROUND: To investigate the risk of developing stroke in patients hospitalized following a diagnosis of pneumococcal pneumonia. METHODS: The study cohorts comprised of patients hospitalized with a principal diagnosis of pneumococcal pneumonia (n = 745), with a random sampling of control individu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3520842?pdf=render |
| _version_ | 1811319579793686528 |
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| author | Li-Fu Chen Hsin-Pai Chen Yung-Sung Huang Kuang-Yung Huang Pesus Chou Ching-Chih Lee |
| author_facet | Li-Fu Chen Hsin-Pai Chen Yung-Sung Huang Kuang-Yung Huang Pesus Chou Ching-Chih Lee |
| author_sort | Li-Fu Chen |
| collection | DOAJ |
| description | BACKGROUND: To investigate the risk of developing stroke in patients hospitalized following a diagnosis of pneumococcal pneumonia. METHODS: The study cohorts comprised of patients hospitalized with a principal diagnosis of pneumococcal pneumonia (n = 745), with a random sampling of control individuals in 2004 (n = 1490). The Cox proportional hazard model was used to compare the stroke-free survival rate between the cohorts after adjusting for possible confounding and risk factors for a two-year follow up. Instrumental variable analysis (IVA) was used to address potential biases associated with measured and unmeasured confounding variables. RESULTS: Of the 153 patients with stroke, 80 (10.7%) were from the pneumococcal pneumonia cohort, and 73 (4.9%) were from the control group. The risk of stroke was 3.65 times higher (95% confidence interval, 2.25-5.90; P<0.001) in patients with pneumococcal pneumonia after adjusting for patient characteristics, co-morbidities, geographic region, urbanization level of residence, and socioeconomic status during the first year. IVA showed an additional 14% risk of stroke for pneumococcal pneumonia patients (odds ratio = 1.14; 95% CI, 1.02-1.26, P = 0.032). CONCLUSIONS: Patients with pneumococcal pneumonia carry an increased risk for stroke than the general population. Further studies are warranted for developing better diagnostic and follow-up strategies for patients with increased risk. |
| first_indexed | 2024-04-13T12:45:27Z |
| format | Article |
| id | doaj.art-5b302a6e0d4d49cbab72c35636fe9d9d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T12:45:27Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5b302a6e0d4d49cbab72c35636fe9d9d2022-12-22T02:46:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5145210.1371/journal.pone.0051452Pneumococcal pneumonia and the risk of stroke: a population-based follow-up study.Li-Fu ChenHsin-Pai ChenYung-Sung HuangKuang-Yung HuangPesus ChouChing-Chih LeeBACKGROUND: To investigate the risk of developing stroke in patients hospitalized following a diagnosis of pneumococcal pneumonia. METHODS: The study cohorts comprised of patients hospitalized with a principal diagnosis of pneumococcal pneumonia (n = 745), with a random sampling of control individuals in 2004 (n = 1490). The Cox proportional hazard model was used to compare the stroke-free survival rate between the cohorts after adjusting for possible confounding and risk factors for a two-year follow up. Instrumental variable analysis (IVA) was used to address potential biases associated with measured and unmeasured confounding variables. RESULTS: Of the 153 patients with stroke, 80 (10.7%) were from the pneumococcal pneumonia cohort, and 73 (4.9%) were from the control group. The risk of stroke was 3.65 times higher (95% confidence interval, 2.25-5.90; P<0.001) in patients with pneumococcal pneumonia after adjusting for patient characteristics, co-morbidities, geographic region, urbanization level of residence, and socioeconomic status during the first year. IVA showed an additional 14% risk of stroke for pneumococcal pneumonia patients (odds ratio = 1.14; 95% CI, 1.02-1.26, P = 0.032). CONCLUSIONS: Patients with pneumococcal pneumonia carry an increased risk for stroke than the general population. Further studies are warranted for developing better diagnostic and follow-up strategies for patients with increased risk.http://europepmc.org/articles/PMC3520842?pdf=render |
| spellingShingle | Li-Fu Chen Hsin-Pai Chen Yung-Sung Huang Kuang-Yung Huang Pesus Chou Ching-Chih Lee Pneumococcal pneumonia and the risk of stroke: a population-based follow-up study. PLoS ONE |
| title | Pneumococcal pneumonia and the risk of stroke: a population-based follow-up study. |
| title_full | Pneumococcal pneumonia and the risk of stroke: a population-based follow-up study. |
| title_fullStr | Pneumococcal pneumonia and the risk of stroke: a population-based follow-up study. |
| title_full_unstemmed | Pneumococcal pneumonia and the risk of stroke: a population-based follow-up study. |
| title_short | Pneumococcal pneumonia and the risk of stroke: a population-based follow-up study. |
| title_sort | pneumococcal pneumonia and the risk of stroke a population based follow up study |
| url | http://europepmc.org/articles/PMC3520842?pdf=render |
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