Targeted Chromatinization and Repression of HIV-1 Provirus Transcription with Repurposed CRISPR/Cas9
The major barrier to HIV-1 cure is the persistence of latent provirus, which is not eradicated by antiretroviral therapy. The “shock and kill” approach entails stimulating viral production with latency-reversing agents followed by the killing of cells actively producing the virus by immune clearance...
Main Authors: | Alex Olson, Binita Basukala, Seunghee Lee, Matthew Gagne, Wilson W. Wong, Andrew J. Henderson |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-10-01
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Series: | Viruses |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4915/12/10/1154 |
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