Indirect spectrophotometric determination of paracetamol via oxidative coupling reaction with 4-(2-pyridylazo)-resorcinoI
A rapid, sensitive and simple spectrophotometric method is proposed for the determination of paracetamol, The method is based on the oxidation of the hydrolytic product of paracetamol by potassium periodate and coupled with 4-(2-pyridylazo)-resorcinoI in the presence of sodium hydroxide. The absorba...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Arabic |
| Published: |
College of Education for Pure Sciences
2006-01-01
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| Series: | مجلة التربية والعلم |
| Subjects: | |
| Online Access: | https://edusj.mosuljournals.com/article_79220_f6ab0e5bb151cfc98afb22a2a419602e.pdf |
| _version_ | 1818175211428642816 |
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| author | Thabit Al-Ghabsha Theiaa N. Al-Sabha Amal Saeed |
| author_facet | Thabit Al-Ghabsha Theiaa N. Al-Sabha Amal Saeed |
| author_sort | Thabit Al-Ghabsha |
| collection | DOAJ |
| description | A rapid, sensitive and simple spectrophotometric method is proposed for the determination of paracetamol, The method is based on the oxidation of the hydrolytic product of paracetamol by potassium periodate and coupled with 4-(2-pyridylazo)-resorcinoI in the presence of sodium hydroxide. The absorbance of the yellowish-brown product is measured at 450 nm and the molar absorptivity found to be 5252 l.mol" '.cm'1. The product conforms to Beer's law over the range 0.4-22.0fig ml". The method is successfully employed for assay of paracetamol in tablets and results have been compared with those obtained by the official method.<br /> Keywords: Paracetamol; oxidative coupling; spectrophotometry. |
| first_indexed | 2024-12-11T19:56:41Z |
| format | Article |
| id | doaj.art-5b32747242bf40c88f69cb3d72a83b50 |
| institution | Directory Open Access Journal |
| issn | 1812-125X 2664-2530 |
| language | Arabic |
| last_indexed | 2024-12-11T19:56:41Z |
| publishDate | 2006-01-01 |
| publisher | College of Education for Pure Sciences |
| record_format | Article |
| series | مجلة التربية والعلم |
| spelling | doaj.art-5b32747242bf40c88f69cb3d72a83b502022-12-22T00:52:37ZaraCollege of Education for Pure Sciencesمجلة التربية والعلم1812-125X2664-25302006-01-01181112110.33899/edusj.2006.7922079220Indirect spectrophotometric determination of paracetamol via oxidative coupling reaction with 4-(2-pyridylazo)-resorcinoIThabit Al-GhabshaTheiaa N. Al-SabhaAmal SaeedA rapid, sensitive and simple spectrophotometric method is proposed for the determination of paracetamol, The method is based on the oxidation of the hydrolytic product of paracetamol by potassium periodate and coupled with 4-(2-pyridylazo)-resorcinoI in the presence of sodium hydroxide. The absorbance of the yellowish-brown product is measured at 450 nm and the molar absorptivity found to be 5252 l.mol" '.cm'1. The product conforms to Beer's law over the range 0.4-22.0fig ml". The method is successfully employed for assay of paracetamol in tablets and results have been compared with those obtained by the official method.<br /> Keywords: Paracetamol; oxidative coupling; spectrophotometry.https://edusj.mosuljournals.com/article_79220_f6ab0e5bb151cfc98afb22a2a419602e.pdfspectrophotometricparacetamoloxidative coupling reactionpyridylazo |
| spellingShingle | Thabit Al-Ghabsha Theiaa N. Al-Sabha Amal Saeed Indirect spectrophotometric determination of paracetamol via oxidative coupling reaction with 4-(2-pyridylazo)-resorcinoI مجلة التربية والعلم spectrophotometric paracetamol oxidative coupling reaction pyridylazo |
| title | Indirect spectrophotometric determination of paracetamol via oxidative coupling reaction with 4-(2-pyridylazo)-resorcinoI |
| title_full | Indirect spectrophotometric determination of paracetamol via oxidative coupling reaction with 4-(2-pyridylazo)-resorcinoI |
| title_fullStr | Indirect spectrophotometric determination of paracetamol via oxidative coupling reaction with 4-(2-pyridylazo)-resorcinoI |
| title_full_unstemmed | Indirect spectrophotometric determination of paracetamol via oxidative coupling reaction with 4-(2-pyridylazo)-resorcinoI |
| title_short | Indirect spectrophotometric determination of paracetamol via oxidative coupling reaction with 4-(2-pyridylazo)-resorcinoI |
| title_sort | indirect spectrophotometric determination of paracetamol via oxidative coupling reaction with 4 2 pyridylazo resorcinoi |
| topic | spectrophotometric paracetamol oxidative coupling reaction pyridylazo |
| url | https://edusj.mosuljournals.com/article_79220_f6ab0e5bb151cfc98afb22a2a419602e.pdf |
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