Development and characterization of niosomal gel of fusidic acid: in-vitro and ex-vivo approaches
Niosomes are multilamellar vesicles that efficiently deliver active substance into skin systemic circulation or skin layers. They are used in topical drug delivery system to enhance the skin permeation of active substance. So, the prime objective of this study was to develop a niosomal gel of fusidi...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Designed Monomers and Polymers |
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| Online Access: | http://dx.doi.org/10.1080/15685551.2022.2086411 |
| _version_ | 1811307371667914752 |
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| author | Muhammad Khurram Waqas Haleema Sadia Muhammad Imran Khan Muhammad Ovais Omer Muhammad Irfan Siddique Shaista Qamar Muhammad Zaman Muhammad Hammad Butt Mian Waqar Mustafa Naeem Rasool |
| author_facet | Muhammad Khurram Waqas Haleema Sadia Muhammad Imran Khan Muhammad Ovais Omer Muhammad Irfan Siddique Shaista Qamar Muhammad Zaman Muhammad Hammad Butt Mian Waqar Mustafa Naeem Rasool |
| author_sort | Muhammad Khurram Waqas |
| collection | DOAJ |
| description | Niosomes are multilamellar vesicles that efficiently deliver active substance into skin systemic circulation or skin layers. They are used in topical drug delivery system to enhance the skin permeation of active substance. So, the prime objective of this study was to develop a niosomal gel of fusidic acid to increase its skin permeation. Different formulations of niosomes of fusidic acid were designed by varying the cholesterol to surfactant ratio. Formulations containing fusidic acid, cholesterol, dihexadecyl pyridinium chloride, Span 60, or Tween 60 were prepared by thin film hydration method in rotary evaporator. The thin film formed in rotary flask was hydrated by phosphate buffer saline of pH 7.2. The niosomes formed were characterized through entrapment efficiency, size, polydispersity index (PDI), and zeta potential. The S3 formulation containing span 60 showed the highest entrapment efficiency (EE) of niosomes, so it was incorporated into Carbopol gel. Determination of pH, spreadability, rheological, and ex vivo permeation studies was conducted of niosomal gel. The results of ex vivo permeation studies showed high permeation of fusidic acid when gel was applied to an albino rat skin. According to the results and previous studies of niosomes, it can be concluded that niosomes enhanced the permeation of fusidic acid through the skin. |
| first_indexed | 2024-04-13T09:03:13Z |
| format | Article |
| id | doaj.art-5b33bcc3615844b482537f330c19f2b8 |
| institution | Directory Open Access Journal |
| issn | 1385-772X 1568-5551 |
| language | English |
| last_indexed | 2024-04-13T09:03:13Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Designed Monomers and Polymers |
| spelling | doaj.art-5b33bcc3615844b482537f330c19f2b82022-12-22T02:53:03ZengTaylor & Francis GroupDesigned Monomers and Polymers1385-772X1568-55512022-12-0125116517410.1080/15685551.2022.20864112086411Development and characterization of niosomal gel of fusidic acid: in-vitro and ex-vivo approachesMuhammad Khurram Waqas0Haleema Sadia1Muhammad Imran Khan2Muhammad Ovais Omer3Muhammad Irfan Siddique4Shaista Qamar5Muhammad Zaman6Muhammad Hammad Butt7Mian Waqar Mustafa8Naeem Rasool9University of Veterinary and Animal SciencesUniversity of Veterinary and Animal SciencesRiphah University Lahore CampusUniversity of Veterinary and Animal Sciences LahoreUniversity of Veterinary and Animal SciencesUniversity of Veterinary and Animal SciencesUniversity of Central PunjabUniversity of Central PunjabForman Christian College UniversityUniversity of Veterinary and Animal Sciences LahoreNiosomes are multilamellar vesicles that efficiently deliver active substance into skin systemic circulation or skin layers. They are used in topical drug delivery system to enhance the skin permeation of active substance. So, the prime objective of this study was to develop a niosomal gel of fusidic acid to increase its skin permeation. Different formulations of niosomes of fusidic acid were designed by varying the cholesterol to surfactant ratio. Formulations containing fusidic acid, cholesterol, dihexadecyl pyridinium chloride, Span 60, or Tween 60 were prepared by thin film hydration method in rotary evaporator. The thin film formed in rotary flask was hydrated by phosphate buffer saline of pH 7.2. The niosomes formed were characterized through entrapment efficiency, size, polydispersity index (PDI), and zeta potential. The S3 formulation containing span 60 showed the highest entrapment efficiency (EE) of niosomes, so it was incorporated into Carbopol gel. Determination of pH, spreadability, rheological, and ex vivo permeation studies was conducted of niosomal gel. The results of ex vivo permeation studies showed high permeation of fusidic acid when gel was applied to an albino rat skin. According to the results and previous studies of niosomes, it can be concluded that niosomes enhanced the permeation of fusidic acid through the skin.http://dx.doi.org/10.1080/15685551.2022.2086411fusidic acidniosomestopicalcarbopol gelpermeation |
| spellingShingle | Muhammad Khurram Waqas Haleema Sadia Muhammad Imran Khan Muhammad Ovais Omer Muhammad Irfan Siddique Shaista Qamar Muhammad Zaman Muhammad Hammad Butt Mian Waqar Mustafa Naeem Rasool Development and characterization of niosomal gel of fusidic acid: in-vitro and ex-vivo approaches Designed Monomers and Polymers fusidic acid niosomes topical carbopol gel permeation |
| title | Development and characterization of niosomal gel of fusidic acid: in-vitro and ex-vivo approaches |
| title_full | Development and characterization of niosomal gel of fusidic acid: in-vitro and ex-vivo approaches |
| title_fullStr | Development and characterization of niosomal gel of fusidic acid: in-vitro and ex-vivo approaches |
| title_full_unstemmed | Development and characterization of niosomal gel of fusidic acid: in-vitro and ex-vivo approaches |
| title_short | Development and characterization of niosomal gel of fusidic acid: in-vitro and ex-vivo approaches |
| title_sort | development and characterization of niosomal gel of fusidic acid in vitro and ex vivo approaches |
| topic | fusidic acid niosomes topical carbopol gel permeation |
| url | http://dx.doi.org/10.1080/15685551.2022.2086411 |
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