Association between serum 25-hydroxyvitamin d and myeloperoxidase: A cross-sectional study of a general population in China
BackgroundSeveral studies have found a strong association between cardiovascular diseases and myeloperoxidase (MPO) as a marker of oxidative stress. Although the anti-inflammatory effects of vitamin D in adults have been validated, evidence about the relationship between MPO and 25(OH)D is lacking....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.948691/full |
| _version_ | 1818001317868601344 |
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| author | Junteng Zhou Junteng Zhou Ruicen Li Ting Bao Wei Jiang Yan Huang |
| author_facet | Junteng Zhou Junteng Zhou Ruicen Li Ting Bao Wei Jiang Yan Huang |
| author_sort | Junteng Zhou |
| collection | DOAJ |
| description | BackgroundSeveral studies have found a strong association between cardiovascular diseases and myeloperoxidase (MPO) as a marker of oxidative stress. Although the anti-inflammatory effects of vitamin D in adults have been validated, evidence about the relationship between MPO and 25(OH)D is lacking. This study aimed to investigate the relationship between MPO and 25(OH)D in the general Chinese population.MethodsFrom November 2018 to August 2019, a total of 6414 subjects were enrolled in a tertiary referral hospital in China, which included 3,122 women and 3,292 men. The dependent and independent variables were MPO and 25(OH)D, respectively. The confounders included age, sex, body mass index, waist-hip ratio, smoking status, alcohol drinking status, calcium, and parathyroid hormone concentration.ResultsIn the fully adjusted model, we found that MPO decreased by 0.12 (95% CI −0.16, −0.08), ng/mL for each unit (1 nmol/L) increase in 25(OH)D. When 25(OH) D was divided into quartiles, compared with Q1 (< 41.4 nmol/L), the adjusted beta coefficients (β) of MPO in Q2–Q4 were −2.29 (95% CI, −4.31 to −0.27), −4.76 (95% CI, −6.83 to −2.69), and −6.07 (95% CI, −8.23 to −3.92), respectively (P for the trend < 0.0001). When 25(OH) D was divided according to clinical severity, compared with the severely deficient (< 30 nmol/L) s≥ 30, < 50 nmol/L) and sufficient groups (≥ 50 nmol/L) were −2.59 (95% CI, −5.87 to 0.69) and −5.87 (95% CI, −9.17 to −2.57), respectively (P for the trend < 0.0001).ConclusionAfter adjusting for age, sex, BMI, waist-hip ratio, smoking status, alcohol status, calcium, and PTH, circulating 25(OH)D was negatively associated with MPO. |
| first_indexed | 2024-04-14T03:31:54Z |
| format | Article |
| id | doaj.art-5b33fa332b4f416d8f1665f49c0ef9ee |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-14T03:31:54Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-5b33fa332b4f416d8f1665f49c0ef9ee2022-12-22T02:14:54ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-08-01910.3389/fnut.2022.948691948691Association between serum 25-hydroxyvitamin d and myeloperoxidase: A cross-sectional study of a general population in ChinaJunteng Zhou0Junteng Zhou1Ruicen Li2Ting Bao3Wei Jiang4Yan Huang5Health Management Center, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Cardiovascular Diseases, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, ChinaHealth Management Center, West China Hospital, Sichuan University, Chengdu, ChinaHealth Management Center, West China Hospital, Sichuan University, Chengdu, ChinaHealth Management Center, West China Hospital, Sichuan University, Chengdu, ChinaHealth Management Center, West China Hospital, Sichuan University, Chengdu, ChinaBackgroundSeveral studies have found a strong association between cardiovascular diseases and myeloperoxidase (MPO) as a marker of oxidative stress. Although the anti-inflammatory effects of vitamin D in adults have been validated, evidence about the relationship between MPO and 25(OH)D is lacking. This study aimed to investigate the relationship between MPO and 25(OH)D in the general Chinese population.MethodsFrom November 2018 to August 2019, a total of 6414 subjects were enrolled in a tertiary referral hospital in China, which included 3,122 women and 3,292 men. The dependent and independent variables were MPO and 25(OH)D, respectively. The confounders included age, sex, body mass index, waist-hip ratio, smoking status, alcohol drinking status, calcium, and parathyroid hormone concentration.ResultsIn the fully adjusted model, we found that MPO decreased by 0.12 (95% CI −0.16, −0.08), ng/mL for each unit (1 nmol/L) increase in 25(OH)D. When 25(OH) D was divided into quartiles, compared with Q1 (< 41.4 nmol/L), the adjusted beta coefficients (β) of MPO in Q2–Q4 were −2.29 (95% CI, −4.31 to −0.27), −4.76 (95% CI, −6.83 to −2.69), and −6.07 (95% CI, −8.23 to −3.92), respectively (P for the trend < 0.0001). When 25(OH) D was divided according to clinical severity, compared with the severely deficient (< 30 nmol/L) s≥ 30, < 50 nmol/L) and sufficient groups (≥ 50 nmol/L) were −2.59 (95% CI, −5.87 to 0.69) and −5.87 (95% CI, −9.17 to −2.57), respectively (P for the trend < 0.0001).ConclusionAfter adjusting for age, sex, BMI, waist-hip ratio, smoking status, alcohol status, calcium, and PTH, circulating 25(OH)D was negatively associated with MPO.https://www.frontiersin.org/articles/10.3389/fnut.2022.948691/fullmyeloperoxidaseassociationcross-sectional studycardiovascular diseases25-dihydroxyvitamin D |
| spellingShingle | Junteng Zhou Junteng Zhou Ruicen Li Ting Bao Wei Jiang Yan Huang Association between serum 25-hydroxyvitamin d and myeloperoxidase: A cross-sectional study of a general population in China Frontiers in Nutrition myeloperoxidase association cross-sectional study cardiovascular diseases 25-dihydroxyvitamin D |
| title | Association between serum 25-hydroxyvitamin d and myeloperoxidase: A cross-sectional study of a general population in China |
| title_full | Association between serum 25-hydroxyvitamin d and myeloperoxidase: A cross-sectional study of a general population in China |
| title_fullStr | Association between serum 25-hydroxyvitamin d and myeloperoxidase: A cross-sectional study of a general population in China |
| title_full_unstemmed | Association between serum 25-hydroxyvitamin d and myeloperoxidase: A cross-sectional study of a general population in China |
| title_short | Association between serum 25-hydroxyvitamin d and myeloperoxidase: A cross-sectional study of a general population in China |
| title_sort | association between serum 25 hydroxyvitamin d and myeloperoxidase a cross sectional study of a general population in china |
| topic | myeloperoxidase association cross-sectional study cardiovascular diseases 25-dihydroxyvitamin D |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.948691/full |
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