A Histological and Morphometric Assessment of the Adult and Juvenile Rat Livers after Mild Traumatic Brain Injury
Traumatic brain injury (TBI) is one of the most severe problems of modern medicine that plays a dominant role in morbidity and mortality in economically developed countries. Our experimental study aimed to evaluate the histological and morphological changes occurring in the liver of adult and juveni...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/5/1121 |
| _version_ | 1797535075588374528 |
|---|---|
| author | Ruslan Prus Olena Appelhans Maksim Logash Petro Pokotylo Grzegorz Józef Nowicki Barbara Ślusarska |
| author_facet | Ruslan Prus Olena Appelhans Maksim Logash Petro Pokotylo Grzegorz Józef Nowicki Barbara Ślusarska |
| author_sort | Ruslan Prus |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) is one of the most severe problems of modern medicine that plays a dominant role in morbidity and mortality in economically developed countries. Our experimental study aimed to evaluate the histological and morphological changes occurring in the liver of adult and juvenile mildly traumatized rats (mTBI) in a time-dependent model. The experiment was performed on 70 adult white rats at three months of age and 70 juvenile rats aged 20 days. The mTBI was modelled by the Impact-Acceleration Model-free fall of weight in the parieto-occipital area. For histopathological comparison, the samples were taken on the 1st, 3rd, 5th, 7th, 14th, and 21st days after TBI. In adult rats, dominated changes in the microcirculatory bed in the form of blood stasis in sinusoidal capillaries and veins, RBC sludge, and adherence to the vessel wall with the subsequent appearance of perivascular and focal leukocytic infiltrates. In juvenile rats, changes in the parenchyma in the form of hepatocyte dystrophy prevailed. In both groups, the highest manifestation of the changes was observed on 5–7 days of the study. On 14–21 days, compensatory phenomena prevailed in both groups. Mild TBI causes changes in the liver of both adult and juvenile rats. The morphological pattern and dynamics of liver changes, due to mild TBI, are different in adult and juvenile rats. |
| first_indexed | 2024-03-10T11:39:49Z |
| format | Article |
| id | doaj.art-5b34783a44d645f7a5d47512e55e995d |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T11:39:49Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5b34783a44d645f7a5d47512e55e995d2023-11-21T18:34:31ZengMDPI AGCells2073-44092021-05-01105112110.3390/cells10051121A Histological and Morphometric Assessment of the Adult and Juvenile Rat Livers after Mild Traumatic Brain InjuryRuslan Prus0Olena Appelhans1Maksim Logash2Petro Pokotylo3Grzegorz Józef Nowicki4Barbara Ślusarska5Department of Normal and Pathological Clinical Anatomy, Odessa National Medical University, UA-65000 Odessa, UkraineDepartment of Normal and Pathological Clinical Anatomy, Odessa National Medical University, UA-65000 Odessa, UkraineDepartment of Normal Anatomy, Lviv National Medical University, UA-79010 Lviv, UkraineDepartment of Normal Anatomy, Lviv National Medical University, UA-79010 Lviv, UkraineDepartment of Family Medicine and Community Nursing, Medical University of Lublin, PL-20-081 Lublin, PolandDepartment of Family Medicine and Community Nursing, Medical University of Lublin, PL-20-081 Lublin, PolandTraumatic brain injury (TBI) is one of the most severe problems of modern medicine that plays a dominant role in morbidity and mortality in economically developed countries. Our experimental study aimed to evaluate the histological and morphological changes occurring in the liver of adult and juvenile mildly traumatized rats (mTBI) in a time-dependent model. The experiment was performed on 70 adult white rats at three months of age and 70 juvenile rats aged 20 days. The mTBI was modelled by the Impact-Acceleration Model-free fall of weight in the parieto-occipital area. For histopathological comparison, the samples were taken on the 1st, 3rd, 5th, 7th, 14th, and 21st days after TBI. In adult rats, dominated changes in the microcirculatory bed in the form of blood stasis in sinusoidal capillaries and veins, RBC sludge, and adherence to the vessel wall with the subsequent appearance of perivascular and focal leukocytic infiltrates. In juvenile rats, changes in the parenchyma in the form of hepatocyte dystrophy prevailed. In both groups, the highest manifestation of the changes was observed on 5–7 days of the study. On 14–21 days, compensatory phenomena prevailed in both groups. Mild TBI causes changes in the liver of both adult and juvenile rats. The morphological pattern and dynamics of liver changes, due to mild TBI, are different in adult and juvenile rats.https://www.mdpi.com/2073-4409/10/5/1121traumatic brain injurymild traumatic brain injuryliverjuvenile ratsextracranial complication |
| spellingShingle | Ruslan Prus Olena Appelhans Maksim Logash Petro Pokotylo Grzegorz Józef Nowicki Barbara Ślusarska A Histological and Morphometric Assessment of the Adult and Juvenile Rat Livers after Mild Traumatic Brain Injury Cells traumatic brain injury mild traumatic brain injury liver juvenile rats extracranial complication |
| title | A Histological and Morphometric Assessment of the Adult and Juvenile Rat Livers after Mild Traumatic Brain Injury |
| title_full | A Histological and Morphometric Assessment of the Adult and Juvenile Rat Livers after Mild Traumatic Brain Injury |
| title_fullStr | A Histological and Morphometric Assessment of the Adult and Juvenile Rat Livers after Mild Traumatic Brain Injury |
| title_full_unstemmed | A Histological and Morphometric Assessment of the Adult and Juvenile Rat Livers after Mild Traumatic Brain Injury |
| title_short | A Histological and Morphometric Assessment of the Adult and Juvenile Rat Livers after Mild Traumatic Brain Injury |
| title_sort | histological and morphometric assessment of the adult and juvenile rat livers after mild traumatic brain injury |
| topic | traumatic brain injury mild traumatic brain injury liver juvenile rats extracranial complication |
| url | https://www.mdpi.com/2073-4409/10/5/1121 |
| work_keys_str_mv | AT ruslanprus ahistologicalandmorphometricassessmentoftheadultandjuvenileratliversaftermildtraumaticbraininjury AT olenaappelhans ahistologicalandmorphometricassessmentoftheadultandjuvenileratliversaftermildtraumaticbraininjury AT maksimlogash ahistologicalandmorphometricassessmentoftheadultandjuvenileratliversaftermildtraumaticbraininjury AT petropokotylo ahistologicalandmorphometricassessmentoftheadultandjuvenileratliversaftermildtraumaticbraininjury AT grzegorzjozefnowicki ahistologicalandmorphometricassessmentoftheadultandjuvenileratliversaftermildtraumaticbraininjury AT barbaraslusarska ahistologicalandmorphometricassessmentoftheadultandjuvenileratliversaftermildtraumaticbraininjury AT ruslanprus histologicalandmorphometricassessmentoftheadultandjuvenileratliversaftermildtraumaticbraininjury AT olenaappelhans histologicalandmorphometricassessmentoftheadultandjuvenileratliversaftermildtraumaticbraininjury AT maksimlogash histologicalandmorphometricassessmentoftheadultandjuvenileratliversaftermildtraumaticbraininjury AT petropokotylo histologicalandmorphometricassessmentoftheadultandjuvenileratliversaftermildtraumaticbraininjury AT grzegorzjozefnowicki histologicalandmorphometricassessmentoftheadultandjuvenileratliversaftermildtraumaticbraininjury AT barbaraslusarska histologicalandmorphometricassessmentoftheadultandjuvenileratliversaftermildtraumaticbraininjury |