Polydopamine surface-modified hyperbranched polymeric nanoparticles for synergistic chemo/photothermal therapy of oral cancer
A novel drug delivery system for the treatment of oral cancer was developed using a facile polydopamine (PDA)-based surface modification and a binding mechanism linking folic acid-targeting ligands. The system was able to achieve the following objectives: loading of chemotherapeutic agents, active t...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1174014/full |
| _version_ | 1827953505177960448 |
|---|---|
| author | Xingyong Yin Xingyong Yin Zimu Li Yi Zhang Xiaowei Zeng Qiuxu Wang Zhigang Liang |
| author_facet | Xingyong Yin Xingyong Yin Zimu Li Yi Zhang Xiaowei Zeng Qiuxu Wang Zhigang Liang |
| author_sort | Xingyong Yin |
| collection | DOAJ |
| description | A novel drug delivery system for the treatment of oral cancer was developed using a facile polydopamine (PDA)-based surface modification and a binding mechanism linking folic acid-targeting ligands. The system was able to achieve the following objectives: loading of chemotherapeutic agents, active targeting, pH responsiveness, and prolonged in vivo blood circulation. DOX-loaded polymeric nanoparticles (DOX/H20-PLA@PDA NPs) were functionalized with amino-poly (ethylene glycol)-folic acid (H2N-PEG-FA) after coating them with PDA to form the targeting combination, DOX/H20-PLA@PDA-PEG-FA NPs. The novel NPs exhibited drug delivery characteristics similar to DOX/H20-PLA@ PDA NPs. Meanwhile, the incorporated H2N-PEG-FA contributed to active targeting, as illustrated in cellular uptake assays and animal studies. In vitro cytotoxicity and in vivo anti-tumor studies have shown that the novel nanoplatforms exhibit extremely effective therapeutic effects. In conclusion, the multifunctional PDA-modified H20-PLA@PDA-PEG-FA NPs offer a promising chemotherapeutic strategy to improve the treatment of oral cancer. |
| first_indexed | 2024-04-09T14:15:09Z |
| format | Article |
| id | doaj.art-5b35ee4f756f4153b63f8938ba17d7d7 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-09T14:15:09Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-5b35ee4f756f4153b63f8938ba17d7d72023-05-05T12:45:47ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-05-011110.3389/fbioe.2023.11740141174014Polydopamine surface-modified hyperbranched polymeric nanoparticles for synergistic chemo/photothermal therapy of oral cancerXingyong Yin0Xingyong Yin1Zimu Li2Yi Zhang3Xiaowei Zeng4Qiuxu Wang5Zhigang Liang6Department of Stomatology, Shenzhen Second People’s Hospital, Shenzhen, ChinaGuangzhou Medical University, Guangzhou, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, ChinaDepartment of Stomatology, Shenzhen Second People’s Hospital, Shenzhen, ChinaDepartment of Stomatology, Shenzhen Second People’s Hospital, Shenzhen, ChinaA novel drug delivery system for the treatment of oral cancer was developed using a facile polydopamine (PDA)-based surface modification and a binding mechanism linking folic acid-targeting ligands. The system was able to achieve the following objectives: loading of chemotherapeutic agents, active targeting, pH responsiveness, and prolonged in vivo blood circulation. DOX-loaded polymeric nanoparticles (DOX/H20-PLA@PDA NPs) were functionalized with amino-poly (ethylene glycol)-folic acid (H2N-PEG-FA) after coating them with PDA to form the targeting combination, DOX/H20-PLA@PDA-PEG-FA NPs. The novel NPs exhibited drug delivery characteristics similar to DOX/H20-PLA@ PDA NPs. Meanwhile, the incorporated H2N-PEG-FA contributed to active targeting, as illustrated in cellular uptake assays and animal studies. In vitro cytotoxicity and in vivo anti-tumor studies have shown that the novel nanoplatforms exhibit extremely effective therapeutic effects. In conclusion, the multifunctional PDA-modified H20-PLA@PDA-PEG-FA NPs offer a promising chemotherapeutic strategy to improve the treatment of oral cancer.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1174014/fullcancer nanotechnologypolydopaminesurface modificationoral cancersynergistic therapy |
| spellingShingle | Xingyong Yin Xingyong Yin Zimu Li Yi Zhang Xiaowei Zeng Qiuxu Wang Zhigang Liang Polydopamine surface-modified hyperbranched polymeric nanoparticles for synergistic chemo/photothermal therapy of oral cancer Frontiers in Bioengineering and Biotechnology cancer nanotechnology polydopamine surface modification oral cancer synergistic therapy |
| title | Polydopamine surface-modified hyperbranched polymeric nanoparticles for synergistic chemo/photothermal therapy of oral cancer |
| title_full | Polydopamine surface-modified hyperbranched polymeric nanoparticles for synergistic chemo/photothermal therapy of oral cancer |
| title_fullStr | Polydopamine surface-modified hyperbranched polymeric nanoparticles for synergistic chemo/photothermal therapy of oral cancer |
| title_full_unstemmed | Polydopamine surface-modified hyperbranched polymeric nanoparticles for synergistic chemo/photothermal therapy of oral cancer |
| title_short | Polydopamine surface-modified hyperbranched polymeric nanoparticles for synergistic chemo/photothermal therapy of oral cancer |
| title_sort | polydopamine surface modified hyperbranched polymeric nanoparticles for synergistic chemo photothermal therapy of oral cancer |
| topic | cancer nanotechnology polydopamine surface modification oral cancer synergistic therapy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1174014/full |
| work_keys_str_mv | AT xingyongyin polydopaminesurfacemodifiedhyperbranchedpolymericnanoparticlesforsynergisticchemophotothermaltherapyoforalcancer AT xingyongyin polydopaminesurfacemodifiedhyperbranchedpolymericnanoparticlesforsynergisticchemophotothermaltherapyoforalcancer AT zimuli polydopaminesurfacemodifiedhyperbranchedpolymericnanoparticlesforsynergisticchemophotothermaltherapyoforalcancer AT yizhang polydopaminesurfacemodifiedhyperbranchedpolymericnanoparticlesforsynergisticchemophotothermaltherapyoforalcancer AT xiaoweizeng polydopaminesurfacemodifiedhyperbranchedpolymericnanoparticlesforsynergisticchemophotothermaltherapyoforalcancer AT qiuxuwang polydopaminesurfacemodifiedhyperbranchedpolymericnanoparticlesforsynergisticchemophotothermaltherapyoforalcancer AT zhigangliang polydopaminesurfacemodifiedhyperbranchedpolymericnanoparticlesforsynergisticchemophotothermaltherapyoforalcancer |