The Application of Biomedicine in Chemodynamic Therapy: From Material Design to Improved Strategies
Chemodynamic therapy (CDT) has garnered significant interest as an innovative approach for cancer treatment, owing to its notable tumor specificity and selectivity, minimal systemic toxicity and side effects, and absence of the requirement for field stimulation during treatment. This treatment utili...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/8/925 |
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| author | Bingwei Cheng Dong Li Changhong Li Ziqi Zhuang Peiyu Wang Gang Liu |
| author_facet | Bingwei Cheng Dong Li Changhong Li Ziqi Zhuang Peiyu Wang Gang Liu |
| author_sort | Bingwei Cheng |
| collection | DOAJ |
| description | Chemodynamic therapy (CDT) has garnered significant interest as an innovative approach for cancer treatment, owing to its notable tumor specificity and selectivity, minimal systemic toxicity and side effects, and absence of the requirement for field stimulation during treatment. This treatment utilizes nanocatalytic medicines containing transitional metals to release metal ions within tumor cells, subsequently initiating Fenton and Fenton-like reactions. These reactions convert hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) into hydroxyl radical (•OH) specifically within the acidic tumor microenvironment (TME), thereby inducing apoptosis in tumor cells. However, insufficient endogenous H<sub>2</sub>O<sub>2</sub>, the overexpressed reducing substances in the TME, and the weak acidity of solid tumors limit the performance of CDT and restrict its application in vivo. Therefore, a variety of nanozymes and strategies have been designed and developed in order to potentiate CDT against tumors, including the application of various nanozymes and different strategies to remodel TME for enhanced CDT (e.g., increasing the H<sub>2</sub>O<sub>2</sub> level in situ, depleting reductive substances, and lowering the pH value). This review presents an overview of the design and development of various nanocatalysts and the corresponding strategies employed to enhance catalytic drug targeting in recent years. Additionally, it delves into the prospects and obstacles that lie ahead for the future advancement of CDT. |
| first_indexed | 2024-03-11T00:06:27Z |
| format | Article |
| id | doaj.art-5b3848e1dae340ac8bd240a29f15654a |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-11T00:06:27Z |
| publishDate | 2023-08-01 |
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| series | Bioengineering |
| spelling | doaj.art-5b3848e1dae340ac8bd240a29f15654a2023-11-19T00:17:56ZengMDPI AGBioengineering2306-53542023-08-0110892510.3390/bioengineering10080925The Application of Biomedicine in Chemodynamic Therapy: From Material Design to Improved StrategiesBingwei Cheng0Dong Li1Changhong Li2Ziqi Zhuang3Peiyu Wang4Gang Liu5State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, ChinaCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, ChinaChemodynamic therapy (CDT) has garnered significant interest as an innovative approach for cancer treatment, owing to its notable tumor specificity and selectivity, minimal systemic toxicity and side effects, and absence of the requirement for field stimulation during treatment. This treatment utilizes nanocatalytic medicines containing transitional metals to release metal ions within tumor cells, subsequently initiating Fenton and Fenton-like reactions. These reactions convert hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) into hydroxyl radical (•OH) specifically within the acidic tumor microenvironment (TME), thereby inducing apoptosis in tumor cells. However, insufficient endogenous H<sub>2</sub>O<sub>2</sub>, the overexpressed reducing substances in the TME, and the weak acidity of solid tumors limit the performance of CDT and restrict its application in vivo. Therefore, a variety of nanozymes and strategies have been designed and developed in order to potentiate CDT against tumors, including the application of various nanozymes and different strategies to remodel TME for enhanced CDT (e.g., increasing the H<sub>2</sub>O<sub>2</sub> level in situ, depleting reductive substances, and lowering the pH value). This review presents an overview of the design and development of various nanocatalysts and the corresponding strategies employed to enhance catalytic drug targeting in recent years. Additionally, it delves into the prospects and obstacles that lie ahead for the future advancement of CDT.https://www.mdpi.com/2306-5354/10/8/925chemodynamic therapyFenton/Fenton-like reactionnanomedicine materialstumor microenvironment |
| spellingShingle | Bingwei Cheng Dong Li Changhong Li Ziqi Zhuang Peiyu Wang Gang Liu The Application of Biomedicine in Chemodynamic Therapy: From Material Design to Improved Strategies Bioengineering chemodynamic therapy Fenton/Fenton-like reaction nanomedicine materials tumor microenvironment |
| title | The Application of Biomedicine in Chemodynamic Therapy: From Material Design to Improved Strategies |
| title_full | The Application of Biomedicine in Chemodynamic Therapy: From Material Design to Improved Strategies |
| title_fullStr | The Application of Biomedicine in Chemodynamic Therapy: From Material Design to Improved Strategies |
| title_full_unstemmed | The Application of Biomedicine in Chemodynamic Therapy: From Material Design to Improved Strategies |
| title_short | The Application of Biomedicine in Chemodynamic Therapy: From Material Design to Improved Strategies |
| title_sort | application of biomedicine in chemodynamic therapy from material design to improved strategies |
| topic | chemodynamic therapy Fenton/Fenton-like reaction nanomedicine materials tumor microenvironment |
| url | https://www.mdpi.com/2306-5354/10/8/925 |
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