Genome-wide CRISPR-Cas9 screen analyzed by SLIDER identifies network of repressor complexes that regulate TRIM24

Genome-wide CRISPR-Cas9 screen analyzed by SLIDER identifies network of repressor complexes that regulate TRIM24

Summary: TRIM24 is an oncogenic chromatin reader that is frequently overexpressed in human tumors and associated with poor prognosis. However, TRIM24 is rarely mutated, duplicated, or rearranged in cancer. This raises questions about how TRIM24 is regulated and what changes in its regulation are res...

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Bibliographic Details
Main Authors:	Lalit R. Patel, Sabrina A. Stratton, Megan McLaughlin, Patrick Krause, Kendra Allton, Andrés López Rivas, Daniela Barbosa, Traver Hart, Michelle C. Barton
Format:	Article
Language:	English
Published:	Elsevier 2023-07-01
Series:	iScience
Subjects:	Cell biology Functional aspects of cell biology Biocomputational method Biochemical classification methods
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223012038

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