Swimming training attenuates the decrease of calcium responsiveness in female infarcted rats
Aim: To evaluate the influence of swimming training on calcium responsiveness of the myocardium of rats with different infarction sizes (MI).Method: female Wistar rats, sedentary sham (SS = 14), sedentary moderate MI (SMI = 8) and sedentary large MI (SLI = 10) were compared to trained sham (TS = 16)...
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.923603/full |
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| author | Leslie Andrews Portes Alexandra Alberta dos Santos Carlos Roberto Padovani Natália Cristina de Oliveira Natália Cristina de Oliveira Andrey Jorge Serra Paulo J. F. Tucci |
| author_facet | Leslie Andrews Portes Alexandra Alberta dos Santos Carlos Roberto Padovani Natália Cristina de Oliveira Natália Cristina de Oliveira Andrey Jorge Serra Paulo J. F. Tucci |
| author_sort | Leslie Andrews Portes |
| collection | DOAJ |
| description | Aim: To evaluate the influence of swimming training on calcium responsiveness of the myocardium of rats with different infarction sizes (MI).Method: female Wistar rats, sedentary sham (SS = 14), sedentary moderate MI (SMI = 8) and sedentary large MI (SLI = 10) were compared to trained sham (TS = 16), trained moderate MI (TMI = 9) and trained large MI (TLI = 10). After 4 weeks of MI, the animals swam for 60 min/day, 5 days/week, for additional 8 weeks. Papillary muscles of the left ventricle were subjected to different concentrations of extracellular calcium. Inotropism was evaluated through the developed tension (DT), the maximum positive value of the first temporal derivation (+Td/td) and the time to peak tension (TPT). Lusitropism was evaluated by the maximum negative value of the first temporal derivation (−Td/td) and time to 50% relaxation (50%TR). Statistical significance was determined using multivariate analysis of variance and a Hotelling T2 test for the absolute power values of all four extracellular calcium concentrations (p < 0.05).Results: MI depressed inotropism (from 17% to 51%) and lusitropism (from 22% to 54%) of the sedentary rats, but exercise attenuated the losses, especially regarding + dT/dt, TPT, −dT/dt and 50%TR. Exercise attenuated the decrease in myocardial responsiveness, proportionally to the size of the MI.Conclusion: Myocardial calcium responsiveness is favorably affected in animals with moderate and large MI after swimming exercise. |
| first_indexed | 2024-04-14T03:04:48Z |
| format | Article |
| id | doaj.art-5b38fcc763ac480d8c458a5f12e25436 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-14T03:04:48Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-5b38fcc763ac480d8c458a5f12e254362022-12-22T02:15:48ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-08-011310.3389/fphys.2022.923603923603Swimming training attenuates the decrease of calcium responsiveness in female infarcted ratsLeslie Andrews Portes0Alexandra Alberta dos Santos1Carlos Roberto Padovani2Natália Cristina de Oliveira3Natália Cristina de Oliveira4Andrey Jorge Serra5Paulo J. F. Tucci6Professor at UNASP, Researcher at LAFEX, Laboratory of Exercise Physiology, Adventist University of Sao Paulo, Sao Paulo, BrazilLaboratory of Cardiac Physiology and Cardiovascular Physiopathology, Federal University of Sao Paulo, Sao Paulo, BrazilDepartment of Biostatistics, Bioscience Institute, UNESP-State University of Sao Paulo, Sao Paulo, BrazilProfessor at UNASP, Researcher at LAFEX, Laboratory of Exercise Physiology, Adventist University of Sao Paulo, Sao Paulo, BrazilMaster Degree Program in Health Promotion at UNASP-Adventist University of São Paulo, Sao Paulo, BrazilLaboratory of Cardiac Physiology and Cardiovascular Physiopathology, Federal University of Sao Paulo, Sao Paulo, BrazilLaboratory of Cardiac Physiology and Cardiovascular Physiopathology, Federal University of Sao Paulo, Sao Paulo, BrazilAim: To evaluate the influence of swimming training on calcium responsiveness of the myocardium of rats with different infarction sizes (MI).Method: female Wistar rats, sedentary sham (SS = 14), sedentary moderate MI (SMI = 8) and sedentary large MI (SLI = 10) were compared to trained sham (TS = 16), trained moderate MI (TMI = 9) and trained large MI (TLI = 10). After 4 weeks of MI, the animals swam for 60 min/day, 5 days/week, for additional 8 weeks. Papillary muscles of the left ventricle were subjected to different concentrations of extracellular calcium. Inotropism was evaluated through the developed tension (DT), the maximum positive value of the first temporal derivation (+Td/td) and the time to peak tension (TPT). Lusitropism was evaluated by the maximum negative value of the first temporal derivation (−Td/td) and time to 50% relaxation (50%TR). Statistical significance was determined using multivariate analysis of variance and a Hotelling T2 test for the absolute power values of all four extracellular calcium concentrations (p < 0.05).Results: MI depressed inotropism (from 17% to 51%) and lusitropism (from 22% to 54%) of the sedentary rats, but exercise attenuated the losses, especially regarding + dT/dt, TPT, −dT/dt and 50%TR. Exercise attenuated the decrease in myocardial responsiveness, proportionally to the size of the MI.Conclusion: Myocardial calcium responsiveness is favorably affected in animals with moderate and large MI after swimming exercise.https://www.frontiersin.org/articles/10.3389/fphys.2022.923603/fullmyocardial infarctionratsinoprotpismlusitropismcalcium responsivityswimming exercise |
| spellingShingle | Leslie Andrews Portes Alexandra Alberta dos Santos Carlos Roberto Padovani Natália Cristina de Oliveira Natália Cristina de Oliveira Andrey Jorge Serra Paulo J. F. Tucci Swimming training attenuates the decrease of calcium responsiveness in female infarcted rats Frontiers in Physiology myocardial infarction rats inoprotpism lusitropism calcium responsivity swimming exercise |
| title | Swimming training attenuates the decrease of calcium responsiveness in female infarcted rats |
| title_full | Swimming training attenuates the decrease of calcium responsiveness in female infarcted rats |
| title_fullStr | Swimming training attenuates the decrease of calcium responsiveness in female infarcted rats |
| title_full_unstemmed | Swimming training attenuates the decrease of calcium responsiveness in female infarcted rats |
| title_short | Swimming training attenuates the decrease of calcium responsiveness in female infarcted rats |
| title_sort | swimming training attenuates the decrease of calcium responsiveness in female infarcted rats |
| topic | myocardial infarction rats inoprotpism lusitropism calcium responsivity swimming exercise |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.923603/full |
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