Role of an Exclusion Diet (Reduced Disaccharides, Saturated Fats, Emulsifiers, Red and Ultraprocessed Meats) in Maintaining the Remission of Chronic Inflammatory Bowel Diseases in Adults
<i>Background and Objectives</i>: Inflammatory bowel diseases are a main focus in current research, with diet being an emerging therapeutic line due to its links in both onset and progression. A Western-style diet high in processed foods, food additives, red meat, and animal fat has been...
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MDPI AG
2023-02-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/2/329 |
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| author | Maria Nitescu Doina Istratescu Carmen Monica Preda Teodora Ecaterina Manuc Edouard Louis Mircea Manuc Tudor Stroie Mihai Catrinoiu Cristian George Tieranu Larisa Emanuela Badea Letitia Tugui Adriana Andrei Mihai Mircea Diculescu |
| author_facet | Maria Nitescu Doina Istratescu Carmen Monica Preda Teodora Ecaterina Manuc Edouard Louis Mircea Manuc Tudor Stroie Mihai Catrinoiu Cristian George Tieranu Larisa Emanuela Badea Letitia Tugui Adriana Andrei Mihai Mircea Diculescu |
| author_sort | Maria Nitescu |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Inflammatory bowel diseases are a main focus in current research, with diet being an emerging therapeutic line due to its links in both onset and progression. A Western-style diet high in processed foods, food additives, red meat, and animal fat has been linked to a higher risk of developing IBD. The aim of this study was to establish an association between an anti-inflammatory exclusion diet and maintenance of remission in IBD. Also, we assessed the efficacy and safety of this diet compared to a non-dietary group and the possible therapeutic effect of this diet in the maintenance of IBD remission. <i>Materials and Methods</i>: A total of 160 patients with IBD were screened for inclusion, but 21 did not met the inclusion criteria. Thus, 139 patients were assigned to either an exclusion diet or a regular diet according to their choice. <i>Results</i>: Clinical remission after six months was maintained in the exclusion diet arm (100%). In the control arm, four patients had clinically active disease (one patient with UC and three with CD), and 90 patients maintained the clinical remission state (95.7%) (<i>p</i>-value = 0.157). Regarding biochemical markers, ESR at baseline was higher in the exclusion diet arm: 29 (5–62) versus in the control arm 16 (4–48) (<i>p</i>-value = 0.019), but six months after, the groups were similar (<i>p</i>-value = 0.440). <i>Conclusions</i>: Patients who followed an exclusion diet maintained clinical remission more frequently. However, the threshold for statistical significance was not achieved. There was also a trend of improvement in inflammation tests in the intervention group. |
| first_indexed | 2024-03-11T08:27:15Z |
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| id | doaj.art-5b396487c6dc4b0481950ec1b3416327 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2025-03-20T00:33:20Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-5b396487c6dc4b0481950ec1b34163272024-10-09T11:11:34ZengMDPI AGMedicina1010-660X1648-91442023-02-0159232910.3390/medicina59020329Role of an Exclusion Diet (Reduced Disaccharides, Saturated Fats, Emulsifiers, Red and Ultraprocessed Meats) in Maintaining the Remission of Chronic Inflammatory Bowel Diseases in AdultsMaria Nitescu0Doina Istratescu1Carmen Monica Preda2Teodora Ecaterina Manuc3Edouard Louis4Mircea Manuc5Tudor Stroie6Mihai Catrinoiu7Cristian George Tieranu8Larisa Emanuela Badea9Letitia Tugui10Adriana Andrei11Mihai Mircea Diculescu12University of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaDepartment of Gastroenterology, University Hospital CHU Liège, 4000 Liège, BelgiumUniversity of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaGastroenterology & Hepatology Department, Elias Emergency Hospital, 011461 Bucharest, RomaniaDepartment of Gastroenterology, Clinic Fundeni Institute, 022328 Bucharest, RomaniaDepartment of Gastroenterology, Clinic Fundeni Institute, 022328 Bucharest, RomaniaDepartment of Gastroenterology, Clinic Fundeni Institute, 022328 Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, Romania<i>Background and Objectives</i>: Inflammatory bowel diseases are a main focus in current research, with diet being an emerging therapeutic line due to its links in both onset and progression. A Western-style diet high in processed foods, food additives, red meat, and animal fat has been linked to a higher risk of developing IBD. The aim of this study was to establish an association between an anti-inflammatory exclusion diet and maintenance of remission in IBD. Also, we assessed the efficacy and safety of this diet compared to a non-dietary group and the possible therapeutic effect of this diet in the maintenance of IBD remission. <i>Materials and Methods</i>: A total of 160 patients with IBD were screened for inclusion, but 21 did not met the inclusion criteria. Thus, 139 patients were assigned to either an exclusion diet or a regular diet according to their choice. <i>Results</i>: Clinical remission after six months was maintained in the exclusion diet arm (100%). In the control arm, four patients had clinically active disease (one patient with UC and three with CD), and 90 patients maintained the clinical remission state (95.7%) (<i>p</i>-value = 0.157). Regarding biochemical markers, ESR at baseline was higher in the exclusion diet arm: 29 (5–62) versus in the control arm 16 (4–48) (<i>p</i>-value = 0.019), but six months after, the groups were similar (<i>p</i>-value = 0.440). <i>Conclusions</i>: Patients who followed an exclusion diet maintained clinical remission more frequently. However, the threshold for statistical significance was not achieved. There was also a trend of improvement in inflammation tests in the intervention group.https://www.mdpi.com/1648-9144/59/2/329inflammatory bowel diseaseCrohn’s diseaseulcerative colitisexclusion diet |
| spellingShingle | Maria Nitescu Doina Istratescu Carmen Monica Preda Teodora Ecaterina Manuc Edouard Louis Mircea Manuc Tudor Stroie Mihai Catrinoiu Cristian George Tieranu Larisa Emanuela Badea Letitia Tugui Adriana Andrei Mihai Mircea Diculescu Role of an Exclusion Diet (Reduced Disaccharides, Saturated Fats, Emulsifiers, Red and Ultraprocessed Meats) in Maintaining the Remission of Chronic Inflammatory Bowel Diseases in Adults Medicina inflammatory bowel disease Crohn’s disease ulcerative colitis exclusion diet |
| title | Role of an Exclusion Diet (Reduced Disaccharides, Saturated Fats, Emulsifiers, Red and Ultraprocessed Meats) in Maintaining the Remission of Chronic Inflammatory Bowel Diseases in Adults |
| title_full | Role of an Exclusion Diet (Reduced Disaccharides, Saturated Fats, Emulsifiers, Red and Ultraprocessed Meats) in Maintaining the Remission of Chronic Inflammatory Bowel Diseases in Adults |
| title_fullStr | Role of an Exclusion Diet (Reduced Disaccharides, Saturated Fats, Emulsifiers, Red and Ultraprocessed Meats) in Maintaining the Remission of Chronic Inflammatory Bowel Diseases in Adults |
| title_full_unstemmed | Role of an Exclusion Diet (Reduced Disaccharides, Saturated Fats, Emulsifiers, Red and Ultraprocessed Meats) in Maintaining the Remission of Chronic Inflammatory Bowel Diseases in Adults |
| title_short | Role of an Exclusion Diet (Reduced Disaccharides, Saturated Fats, Emulsifiers, Red and Ultraprocessed Meats) in Maintaining the Remission of Chronic Inflammatory Bowel Diseases in Adults |
| title_sort | role of an exclusion diet reduced disaccharides saturated fats emulsifiers red and ultraprocessed meats in maintaining the remission of chronic inflammatory bowel diseases in adults |
| topic | inflammatory bowel disease Crohn’s disease ulcerative colitis exclusion diet |
| url | https://www.mdpi.com/1648-9144/59/2/329 |
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