Artifact-Removed Quantitative Analysis of Choriocapillaris Flow Voids
Objectives:To investigate choriocapillaris flow voids (FV) with a new optical coherence tomography angiography (OCTA) image processing strategy that can eliminate artifacts caused by vitreous opacities, sub-retinal pigment epithelium fluid and deposits, and subretinal fluid (SRF) by thresholding the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2023-02-01
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| Series: | Türk Oftalmoloji Dergisi |
| Subjects: | |
| Online Access: |
http://www.oftalmoloji.org/archives/archive-detail/article-preview/artifact-removed-quantitative-analysis-of-chorioca/58683
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| _version_ | 1797894328712953856 |
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| author | M. Giray Ersöz Mümin Hocaoğlu Işıl Sayman Muslubaş Serra Arf Erdost Yıldız Murat Karaçorlu |
| author_facet | M. Giray Ersöz Mümin Hocaoğlu Işıl Sayman Muslubaş Serra Arf Erdost Yıldız Murat Karaçorlu |
| author_sort | M. Giray Ersöz |
| collection | DOAJ |
| description | Objectives:To investigate choriocapillaris flow voids (FV) with a new optical coherence tomography angiography (OCTA) image processing strategy that can eliminate artifacts caused by vitreous opacities, sub-retinal pigment epithelium fluid and deposits, and subretinal fluid (SRF) by thresholding the en-face OCT image of the outer retina.Materials and Methods:We retrospectively reviewed medical records of patients with drusen and patients with active central serous chorioretinopathy (CSC). FV number (FVn), average area (FVav), and maximum area (FVmax) and the percentage of nonperfused choriocapillaris area (PNPCA) obtained using the proposed strategy were compared with those obtained by removing only artifacts caused by the superficial capillary plexus (SCP).Results:The SRF group included 21 eyes with active CSC and the drusen group included 29 eyes with nonexudative age-related macular degeneration. FVav, FVmax, FVn, and PNPCA obtained using the algorithm were significantly lower than those obtained by removing only SCP-related artefacts in both groups (all p<0.05). The algorithm was also able to remove 96.9% of artifacts secondary to vitreous opacities and all artifacts secondary to serous pigment epithelial detachments.Conclusion:Choriocapillaris nonperfusion areas on OCTA images may be overestimated in eyes with RPE abnormalities and SRF due to artifacts. These artifact areas on choriocapillaris OCTA images can be removed using thresholded images of the outer retina en-face OCT scans. Our new artifact-removal strategy is useful in the assessment of choriocapillaris FV in eyes with SRF, drusen, drusen-like deposits, and pigment epithelial detachment. |
| first_indexed | 2024-04-10T07:07:11Z |
| format | Article |
| id | doaj.art-5b3a06a2e36d4c4db9154d90a05acac4 |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-04-10T07:07:11Z |
| publishDate | 2023-02-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-5b3a06a2e36d4c4db9154d90a05acac42023-02-27T05:53:27ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612023-02-01531374310.4274/tjo.galenos.2022.2385513049054Artifact-Removed Quantitative Analysis of Choriocapillaris Flow VoidsM. Giray Ersöz0Mümin Hocaoğlu1Işıl Sayman Muslubaş2Serra Arf3Erdost Yıldız4Murat Karaçorlu5 Biruni Üniversitesi Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, İstanbul, Türkiye İstanbul Retina Enstitüsü, İstanbul, Türkiye İstanbul Retina Enstitüsü, İstanbul, Türkiye İstanbul Retina Enstitüsü, İstanbul, Türkiye Koç Üniversitesi Tıp Fakültesi, Translasyonel Tıp Uygulama ve Araştırma Merkezi, İstanbul, Türkiye İstanbul Retina Enstitüsü, İstanbul, Türkiye Objectives:To investigate choriocapillaris flow voids (FV) with a new optical coherence tomography angiography (OCTA) image processing strategy that can eliminate artifacts caused by vitreous opacities, sub-retinal pigment epithelium fluid and deposits, and subretinal fluid (SRF) by thresholding the en-face OCT image of the outer retina.Materials and Methods:We retrospectively reviewed medical records of patients with drusen and patients with active central serous chorioretinopathy (CSC). FV number (FVn), average area (FVav), and maximum area (FVmax) and the percentage of nonperfused choriocapillaris area (PNPCA) obtained using the proposed strategy were compared with those obtained by removing only artifacts caused by the superficial capillary plexus (SCP).Results:The SRF group included 21 eyes with active CSC and the drusen group included 29 eyes with nonexudative age-related macular degeneration. FVav, FVmax, FVn, and PNPCA obtained using the algorithm were significantly lower than those obtained by removing only SCP-related artefacts in both groups (all p<0.05). The algorithm was also able to remove 96.9% of artifacts secondary to vitreous opacities and all artifacts secondary to serous pigment epithelial detachments.Conclusion:Choriocapillaris nonperfusion areas on OCTA images may be overestimated in eyes with RPE abnormalities and SRF due to artifacts. These artifact areas on choriocapillaris OCTA images can be removed using thresholded images of the outer retina en-face OCT scans. Our new artifact-removal strategy is useful in the assessment of choriocapillaris FV in eyes with SRF, drusen, drusen-like deposits, and pigment epithelial detachment. http://www.oftalmoloji.org/archives/archive-detail/article-preview/artifact-removed-quantitative-analysis-of-chorioca/58683 artifact removalchoriocapillaris flow voidsdrusenoptical coherence tomography angiographysubretinal fluid |
| spellingShingle | M. Giray Ersöz Mümin Hocaoğlu Işıl Sayman Muslubaş Serra Arf Erdost Yıldız Murat Karaçorlu Artifact-Removed Quantitative Analysis of Choriocapillaris Flow Voids Türk Oftalmoloji Dergisi artifact removal choriocapillaris flow voids drusen optical coherence tomography angiography subretinal fluid |
| title | Artifact-Removed Quantitative Analysis of Choriocapillaris Flow Voids |
| title_full | Artifact-Removed Quantitative Analysis of Choriocapillaris Flow Voids |
| title_fullStr | Artifact-Removed Quantitative Analysis of Choriocapillaris Flow Voids |
| title_full_unstemmed | Artifact-Removed Quantitative Analysis of Choriocapillaris Flow Voids |
| title_short | Artifact-Removed Quantitative Analysis of Choriocapillaris Flow Voids |
| title_sort | artifact removed quantitative analysis of choriocapillaris flow voids |
| topic | artifact removal choriocapillaris flow voids drusen optical coherence tomography angiography subretinal fluid |
| url |
http://www.oftalmoloji.org/archives/archive-detail/article-preview/artifact-removed-quantitative-analysis-of-chorioca/58683
|
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