Cytokines and Leukocytes Subpopulations Profile in SARS-CoV-2 Patients Depending on the CT Score Severity
The role of the adaptive microenvironment components in severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection is widely researched, but remains unclear. Studying the common dynamics of adaptive immune response changes can help understand the pathogenesis of coronavirus disease 2019...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/5/880 |
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| author | Elżbieta Rutkowska Iwona Kwiecień Magdalena Żabicka Artur Maliborski Agata Raniszewska Krzysztof Kłos Weronika Urbańska Izabella Klajnowicz Piotr Rzepecki Andrzej Chciałowski |
| author_facet | Elżbieta Rutkowska Iwona Kwiecień Magdalena Żabicka Artur Maliborski Agata Raniszewska Krzysztof Kłos Weronika Urbańska Izabella Klajnowicz Piotr Rzepecki Andrzej Chciałowski |
| author_sort | Elżbieta Rutkowska |
| collection | DOAJ |
| description | The role of the adaptive microenvironment components in severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection is widely researched, but remains unclear. Studying the common dynamics of adaptive immune response changes can help understand the pathogenesis of coronavirus disease 2019 (COVID-19), especially in critical patients. The aim of the present study was to determine the cytokines concentration and leukocyte subpopulations profiles in the severe COVID-19 (<i>n</i> = 23) and critical (<i>n</i> = 18) COVID-19 group distinguished by the computed tomography (CT) severity score. We observed lower percentage of lymphocyte subpopulation, higher neutrophils to lymphocytes ratio (NLR) and higher IL-6 concentration in critical COVID-19 group than in severe group. CT severity score was negative correlated with proportion of lymphocytes, lymphocytes T, CD4+ cells, Treg cells and NK cells and positive correlated with neutrophils, NLR, and IL-6. In critical group more correlations between cytokines and lymphocytes were observed, mainly between TNF-α, IL-1β and lymphocyte subpopulations. The collective assessment of the cytokine profile, leukocyte subpopulations and the CT severity score can help to characterize and differentiate patient in advanced COVID-19 than the study of single parameters. We have shown that the interconnection of elements of the adaptive microenvironment can play an important role in critical COVID-19 cases. |
| first_indexed | 2024-03-10T11:31:37Z |
| format | Article |
| id | doaj.art-5b3a1388547542299ada8cd8cb8e634f |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T11:31:37Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-5b3a1388547542299ada8cd8cb8e634f2023-11-21T19:10:11ZengMDPI AGViruses1999-49152021-05-0113588010.3390/v13050880Cytokines and Leukocytes Subpopulations Profile in SARS-CoV-2 Patients Depending on the CT Score SeverityElżbieta Rutkowska0Iwona Kwiecień1Magdalena Żabicka2Artur Maliborski3Agata Raniszewska4Krzysztof Kłos5Weronika Urbańska6Izabella Klajnowicz7Piotr Rzepecki8Andrzej Chciałowski9Laboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine, 04-141 Warsaw, PolandLaboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine, 04-141 Warsaw, PolandDepartment of Radiology, Military Institute of Medicine, 04-141 Warsaw, PolandDepartment of Radiology, Military Institute of Medicine, 04-141 Warsaw, PolandLaboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine, 04-141 Warsaw, PolandDepartment of Infectious Diseases and Allergology, Military Institute of Medicine, 04-141 Warsaw, PolandDepartment of Infectious Diseases and Allergology, Military Institute of Medicine, 04-141 Warsaw, PolandDepartment of Infectious Diseases and Allergology, Military Institute of Medicine, 04-141 Warsaw, PolandDepartment of Internal Medicine and Hematology, Military Institute of Medicine, 04-141 Warsaw, PolandDepartment of Infectious Diseases and Allergology, Military Institute of Medicine, 04-141 Warsaw, PolandThe role of the adaptive microenvironment components in severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection is widely researched, but remains unclear. Studying the common dynamics of adaptive immune response changes can help understand the pathogenesis of coronavirus disease 2019 (COVID-19), especially in critical patients. The aim of the present study was to determine the cytokines concentration and leukocyte subpopulations profiles in the severe COVID-19 (<i>n</i> = 23) and critical (<i>n</i> = 18) COVID-19 group distinguished by the computed tomography (CT) severity score. We observed lower percentage of lymphocyte subpopulation, higher neutrophils to lymphocytes ratio (NLR) and higher IL-6 concentration in critical COVID-19 group than in severe group. CT severity score was negative correlated with proportion of lymphocytes, lymphocytes T, CD4+ cells, Treg cells and NK cells and positive correlated with neutrophils, NLR, and IL-6. In critical group more correlations between cytokines and lymphocytes were observed, mainly between TNF-α, IL-1β and lymphocyte subpopulations. The collective assessment of the cytokine profile, leukocyte subpopulations and the CT severity score can help to characterize and differentiate patient in advanced COVID-19 than the study of single parameters. We have shown that the interconnection of elements of the adaptive microenvironment can play an important role in critical COVID-19 cases.https://www.mdpi.com/1999-4915/13/5/880SARS-CoV-2leukocytelymphocyteT regulatory cellcytokinesIL-6 |
| spellingShingle | Elżbieta Rutkowska Iwona Kwiecień Magdalena Żabicka Artur Maliborski Agata Raniszewska Krzysztof Kłos Weronika Urbańska Izabella Klajnowicz Piotr Rzepecki Andrzej Chciałowski Cytokines and Leukocytes Subpopulations Profile in SARS-CoV-2 Patients Depending on the CT Score Severity Viruses SARS-CoV-2 leukocyte lymphocyte T regulatory cell cytokines IL-6 |
| title | Cytokines and Leukocytes Subpopulations Profile in SARS-CoV-2 Patients Depending on the CT Score Severity |
| title_full | Cytokines and Leukocytes Subpopulations Profile in SARS-CoV-2 Patients Depending on the CT Score Severity |
| title_fullStr | Cytokines and Leukocytes Subpopulations Profile in SARS-CoV-2 Patients Depending on the CT Score Severity |
| title_full_unstemmed | Cytokines and Leukocytes Subpopulations Profile in SARS-CoV-2 Patients Depending on the CT Score Severity |
| title_short | Cytokines and Leukocytes Subpopulations Profile in SARS-CoV-2 Patients Depending on the CT Score Severity |
| title_sort | cytokines and leukocytes subpopulations profile in sars cov 2 patients depending on the ct score severity |
| topic | SARS-CoV-2 leukocyte lymphocyte T regulatory cell cytokines IL-6 |
| url | https://www.mdpi.com/1999-4915/13/5/880 |
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