Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes

Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes

Summary: The eukaryotic BBSome is a transport complex within cilia and assembled by chaperonin-like BBS proteins. Recent work indicates nuclear functions for BBS proteins in mammals, but it is unclear how common these are in extant proteins or when they evolved. We screened for BBS orthologues acros...

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Bibliographic Details
Main Authors: Alexander Ewerling, Vanessa Maissl, Bill Wickstead, Helen Louise May-Simera
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Molecular biology
Evolutionary biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422300487X

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