Measurement of glomerular filtration rate in patients undergoing obesity surgery
Abstract Background Most studies on obesity surgery have measured renal function using the estimated GFR. However, due to the reduction of muscle mass, and therefore creatinine that accompanies weight loss, such measures can falsely suggest an improvement in renal function. To balance the risks of s...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12882-018-1188-7 |
| _version_ | 1818385487270772736 |
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| author | Ling L. Chuah Alexander D. Miras Laura M. Perry Andrew H. Frankel David J. Towey Zahraa Al-Mayahi William Svensson Carel W. le Roux |
| author_facet | Ling L. Chuah Alexander D. Miras Laura M. Perry Andrew H. Frankel David J. Towey Zahraa Al-Mayahi William Svensson Carel W. le Roux |
| author_sort | Ling L. Chuah |
| collection | DOAJ |
| description | Abstract Background Most studies on obesity surgery have measured renal function using the estimated GFR. However, due to the reduction of muscle mass, and therefore creatinine that accompanies weight loss, such measures can falsely suggest an improvement in renal function. To balance the risks of surgery versus any potential benefits on renal function, we need to be able to determine renal function using valid and reliable methodologies. In this pilot study we aimed to measure renal function in patients with CKD undergoing obesity surgery using the gold standard 51Cr-EDTA GFR clearance methodology which is independent of measures of muscle mass. Methods Nine consecutive obese patients with CKD underwent obesity surgery. Their renal function was assessed using 51Cr-EDTA GFR, cystatin C and serum creatinine as well as using eGFR equations including MDRD CKD Epi, Cockcroft Gault and CKD Epi cystatin before and 12 months after surgery. Results Renal function using the 51Cr-EDTA measured GFR did not change significantly after surgery. Similar results were obtained when Cystatin C, CKD Epi cystatin, CKD Epi cystatin creatinine and adjusted Cockcroft Gault Creatinine clearance methods were used. In contrast there were either trends or significant improvements in renal function measured using the MDRD and CKD Epi equations. Conclusions In this pilot study using the gold standard 51Cr-EDTA method we found stabilisation in renal function after obesity surgery. Until further definitive data emerge it is critical to balance the risk and benefits of surgery, especially if renal function may not improve as often as previously suggested. Trial registration ClinicalTrials.gov NCT01507350. Registered June 2011. |
| first_indexed | 2024-12-14T03:38:56Z |
| format | Article |
| id | doaj.art-5b3ad2ad883b426a8c9aa06201fe2184 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-14T03:38:56Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-5b3ad2ad883b426a8c9aa06201fe21842022-12-21T23:18:33ZengBMCBMC Nephrology1471-23692018-12-011911410.1186/s12882-018-1188-7Measurement of glomerular filtration rate in patients undergoing obesity surgeryLing L. Chuah0Alexander D. Miras1Laura M. Perry2Andrew H. Frankel3David J. Towey4Zahraa Al-Mayahi5William Svensson6Carel W. le Roux7Section of Investigative Medicine, Imperial College LondonSection of Investigative Medicine, Imperial College LondonRadiological Sciences Unit, Imperial College Healthcare NHS TrustNephrology, Imperial College Healthcare NHS TrustRadiological Sciences Unit, Imperial College Healthcare NHS TrustSection of Investigative Medicine, Imperial College LondonNuclear Medicine, Imperial College Healthcare NHS TrustSection of Investigative Medicine, Imperial College LondonAbstract Background Most studies on obesity surgery have measured renal function using the estimated GFR. However, due to the reduction of muscle mass, and therefore creatinine that accompanies weight loss, such measures can falsely suggest an improvement in renal function. To balance the risks of surgery versus any potential benefits on renal function, we need to be able to determine renal function using valid and reliable methodologies. In this pilot study we aimed to measure renal function in patients with CKD undergoing obesity surgery using the gold standard 51Cr-EDTA GFR clearance methodology which is independent of measures of muscle mass. Methods Nine consecutive obese patients with CKD underwent obesity surgery. Their renal function was assessed using 51Cr-EDTA GFR, cystatin C and serum creatinine as well as using eGFR equations including MDRD CKD Epi, Cockcroft Gault and CKD Epi cystatin before and 12 months after surgery. Results Renal function using the 51Cr-EDTA measured GFR did not change significantly after surgery. Similar results were obtained when Cystatin C, CKD Epi cystatin, CKD Epi cystatin creatinine and adjusted Cockcroft Gault Creatinine clearance methods were used. In contrast there were either trends or significant improvements in renal function measured using the MDRD and CKD Epi equations. Conclusions In this pilot study using the gold standard 51Cr-EDTA method we found stabilisation in renal function after obesity surgery. Until further definitive data emerge it is critical to balance the risk and benefits of surgery, especially if renal function may not improve as often as previously suggested. Trial registration ClinicalTrials.gov NCT01507350. Registered June 2011.http://link.springer.com/article/10.1186/s12882-018-1188-7RenalCreatinineBariatricCr-EDTAGFR |
| spellingShingle | Ling L. Chuah Alexander D. Miras Laura M. Perry Andrew H. Frankel David J. Towey Zahraa Al-Mayahi William Svensson Carel W. le Roux Measurement of glomerular filtration rate in patients undergoing obesity surgery BMC Nephrology Renal Creatinine Bariatric Cr-EDTA GFR |
| title | Measurement of glomerular filtration rate in patients undergoing obesity surgery |
| title_full | Measurement of glomerular filtration rate in patients undergoing obesity surgery |
| title_fullStr | Measurement of glomerular filtration rate in patients undergoing obesity surgery |
| title_full_unstemmed | Measurement of glomerular filtration rate in patients undergoing obesity surgery |
| title_short | Measurement of glomerular filtration rate in patients undergoing obesity surgery |
| title_sort | measurement of glomerular filtration rate in patients undergoing obesity surgery |
| topic | Renal Creatinine Bariatric Cr-EDTA GFR |
| url | http://link.springer.com/article/10.1186/s12882-018-1188-7 |
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