Global Distribution and Natural Recombination of Hepatitis D Virus: Implication of Kyrgyzstan Emerging HDVs in the Clinical Outcomes
Discrepancies in human hepatitis delta virus (HDV) genotypes impact the virus’ biological behavior, clinical manifestation, and treatment response. Herein, this report aims to explore the role of recombination in the worldwide genotypic distribution and genetic diversity of HDV. Three-hundred-forty-...
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MDPI AG
2022-07-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/7/1467 |
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| author | Amina Nawal Bahoussi Pei-Hua Wang Yan-Yan Guo Nighat Rabbani Changxin Wu Li Xing |
| author_facet | Amina Nawal Bahoussi Pei-Hua Wang Yan-Yan Guo Nighat Rabbani Changxin Wu Li Xing |
| author_sort | Amina Nawal Bahoussi |
| collection | DOAJ |
| description | Discrepancies in human hepatitis delta virus (HDV) genotypes impact the virus’ biological behavior, clinical manifestation, and treatment response. Herein, this report aims to explore the role of recombination in the worldwide genotypic distribution and genetic diversity of HDV. Three-hundred-forty-eight human HDV full-length genomic sequences of ~1678 nt in length, isolated in twenty-eight countries worldwide between 1986 and 2018, were analysed. Similarity analysis and recombination mapping were performed, and forty-eight recombination events were identified, twenty-nine of which were isolated from Kyrgyzstan and determined to be involved in the diversity and extension of HDV sub-genotypes. HDV recombination occurred only between the genetically close genotypes (genotype 5 and genotype 2) or mainly within genotype 1, suggesting the complex replicative molecular mechanisms of HDV-RNA. The global distribution and classification of HDV genotypes have been updated, indicating that HDV recombination is one of the driving forces behind the biodiversity and the evolution of human HDV genomes. The outcome analysis suggests that the expansion of HDV sub-genotypes and the complex recombination networks might be related to the genomic character of Kyrgyzstan circulating strains and extensive mobility within countries and across borders. These findings will be of great importance in formulating more effective public health HDV surveillance strategies and guiding future molecular and epidemiological research to achieve better clinical outcomes. |
| first_indexed | 2024-03-09T10:10:22Z |
| format | Article |
| id | doaj.art-5b3d2b3d9ba34618a44899361b5588b9 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T10:10:22Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
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| series | Viruses |
| spelling | doaj.art-5b3d2b3d9ba34618a44899361b5588b92023-12-01T22:47:10ZengMDPI AGViruses1999-49152022-07-01147146710.3390/v14071467Global Distribution and Natural Recombination of Hepatitis D Virus: Implication of Kyrgyzstan Emerging HDVs in the Clinical OutcomesAmina Nawal Bahoussi0Pei-Hua Wang1Yan-Yan Guo2Nighat Rabbani3Changxin Wu4Li Xing5Institutes of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan 030006, ChinaInstitutes of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan 030006, ChinaInstitutes of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan 030006, ChinaInstitutes of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan 030006, ChinaInstitutes of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan 030006, ChinaInstitutes of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan 030006, ChinaDiscrepancies in human hepatitis delta virus (HDV) genotypes impact the virus’ biological behavior, clinical manifestation, and treatment response. Herein, this report aims to explore the role of recombination in the worldwide genotypic distribution and genetic diversity of HDV. Three-hundred-forty-eight human HDV full-length genomic sequences of ~1678 nt in length, isolated in twenty-eight countries worldwide between 1986 and 2018, were analysed. Similarity analysis and recombination mapping were performed, and forty-eight recombination events were identified, twenty-nine of which were isolated from Kyrgyzstan and determined to be involved in the diversity and extension of HDV sub-genotypes. HDV recombination occurred only between the genetically close genotypes (genotype 5 and genotype 2) or mainly within genotype 1, suggesting the complex replicative molecular mechanisms of HDV-RNA. The global distribution and classification of HDV genotypes have been updated, indicating that HDV recombination is one of the driving forces behind the biodiversity and the evolution of human HDV genomes. The outcome analysis suggests that the expansion of HDV sub-genotypes and the complex recombination networks might be related to the genomic character of Kyrgyzstan circulating strains and extensive mobility within countries and across borders. These findings will be of great importance in formulating more effective public health HDV surveillance strategies and guiding future molecular and epidemiological research to achieve better clinical outcomes.https://www.mdpi.com/1999-4915/14/7/1467<i>Deltavirus</i> genusHDV RNAviroidgenotypephylogenetic analysisgenomic recombination |
| spellingShingle | Amina Nawal Bahoussi Pei-Hua Wang Yan-Yan Guo Nighat Rabbani Changxin Wu Li Xing Global Distribution and Natural Recombination of Hepatitis D Virus: Implication of Kyrgyzstan Emerging HDVs in the Clinical Outcomes Viruses <i>Deltavirus</i> genus HDV RNA viroid genotype phylogenetic analysis genomic recombination |
| title | Global Distribution and Natural Recombination of Hepatitis D Virus: Implication of Kyrgyzstan Emerging HDVs in the Clinical Outcomes |
| title_full | Global Distribution and Natural Recombination of Hepatitis D Virus: Implication of Kyrgyzstan Emerging HDVs in the Clinical Outcomes |
| title_fullStr | Global Distribution and Natural Recombination of Hepatitis D Virus: Implication of Kyrgyzstan Emerging HDVs in the Clinical Outcomes |
| title_full_unstemmed | Global Distribution and Natural Recombination of Hepatitis D Virus: Implication of Kyrgyzstan Emerging HDVs in the Clinical Outcomes |
| title_short | Global Distribution and Natural Recombination of Hepatitis D Virus: Implication of Kyrgyzstan Emerging HDVs in the Clinical Outcomes |
| title_sort | global distribution and natural recombination of hepatitis d virus implication of kyrgyzstan emerging hdvs in the clinical outcomes |
| topic | <i>Deltavirus</i> genus HDV RNA viroid genotype phylogenetic analysis genomic recombination |
| url | https://www.mdpi.com/1999-4915/14/7/1467 |
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