Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease
Sterile inflammation develops as part of an innate immunity response to molecules released upon tissue injury and collectively indicated as damage-associated molecular patterns (DAMPs). While coordinating the clearance of potential harmful stimuli, promotion of tissue repair, and restoration of tiss...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.601740/full |
| _version_ | 1828803444810448896 |
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| author | Anna Picca Anna Picca Flora Guerra Riccardo Calvani Riccardo Calvani Hélio José Coelho-Júnior Francesco Landi Francesco Landi Roberto Bernabei Roberto Bernabei Roberta Romano Cecilia Bucci Emanuele Marzetti Emanuele Marzetti |
| author_facet | Anna Picca Anna Picca Flora Guerra Riccardo Calvani Riccardo Calvani Hélio José Coelho-Júnior Francesco Landi Francesco Landi Roberto Bernabei Roberto Bernabei Roberta Romano Cecilia Bucci Emanuele Marzetti Emanuele Marzetti |
| author_sort | Anna Picca |
| collection | DOAJ |
| description | Sterile inflammation develops as part of an innate immunity response to molecules released upon tissue injury and collectively indicated as damage-associated molecular patterns (DAMPs). While coordinating the clearance of potential harmful stimuli, promotion of tissue repair, and restoration of tissue homeostasis, a hyper-activation of such an inflammatory response may be detrimental. The complex regulatory pathways modulating DAMPs generation and trafficking are actively investigated for their potential to provide relevant insights into physiological and pathological conditions. Abnormal circulating extracellular vesicles (EVs) stemming from altered endosomal-lysosomal system have also been reported in several age-related conditions, including cancer and neurodegeneration, and indicated as a promising route for therapeutic purposes. Along this pathway, mitochondria may dispose altered components to preserve organelle homeostasis. However, whether a common thread exists between DAMPs and EVs generation is yet to be clarified. A deeper understanding of the highly complex, dynamic, and variable intracellular and extracellular trafficking of DAMPs and EVs, including those of mitochondrial origin, is needed to unveil relevant pathogenic pathways and novel targets for drug development. Herein, we describe the mechanisms of generation of EVs and mitochondrial-derived vesicles along the endocytic pathway and discuss the involvement of the endosomal-lysosomal in cancer and neurodegeneration (i.e., Alzheimer’s and Parkinson’s disease). |
| first_indexed | 2024-12-12T07:23:36Z |
| format | Article |
| id | doaj.art-5b3db8f2442542b98dbae2159bbfc35e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T07:23:36Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-5b3db8f2442542b98dbae2159bbfc35e2022-12-22T00:33:14ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-11-011110.3389/fimmu.2020.601740601740Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and DiseaseAnna Picca0Anna Picca1Flora Guerra2Riccardo Calvani3Riccardo Calvani4Hélio José Coelho-Júnior5Francesco Landi6Francesco Landi7Roberto Bernabei8Roberto Bernabei9Roberta Romano10Cecilia Bucci11Emanuele Marzetti12Emanuele Marzetti13Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, ItalyAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, SwedenDepartment of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, ItalyAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, SwedenUniversità Cattolica del Sacro Cuore, Rome, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, ItalyUniversità Cattolica del Sacro Cuore, Rome, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, ItalyUniversità Cattolica del Sacro Cuore, Rome, ItalyDepartment of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, ItalyDepartment of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, ItalyUniversità Cattolica del Sacro Cuore, Rome, ItalySterile inflammation develops as part of an innate immunity response to molecules released upon tissue injury and collectively indicated as damage-associated molecular patterns (DAMPs). While coordinating the clearance of potential harmful stimuli, promotion of tissue repair, and restoration of tissue homeostasis, a hyper-activation of such an inflammatory response may be detrimental. The complex regulatory pathways modulating DAMPs generation and trafficking are actively investigated for their potential to provide relevant insights into physiological and pathological conditions. Abnormal circulating extracellular vesicles (EVs) stemming from altered endosomal-lysosomal system have also been reported in several age-related conditions, including cancer and neurodegeneration, and indicated as a promising route for therapeutic purposes. Along this pathway, mitochondria may dispose altered components to preserve organelle homeostasis. However, whether a common thread exists between DAMPs and EVs generation is yet to be clarified. A deeper understanding of the highly complex, dynamic, and variable intracellular and extracellular trafficking of DAMPs and EVs, including those of mitochondrial origin, is needed to unveil relevant pathogenic pathways and novel targets for drug development. Herein, we describe the mechanisms of generation of EVs and mitochondrial-derived vesicles along the endocytic pathway and discuss the involvement of the endosomal-lysosomal in cancer and neurodegeneration (i.e., Alzheimer’s and Parkinson’s disease).https://www.frontiersin.org/articles/10.3389/fimmu.2020.601740/fullAlzheimer’s diseasedamage-associated molecular patternsendo-lysosomal systeminflammationinnate immunitymitochondrial-derived vesicles |
| spellingShingle | Anna Picca Anna Picca Flora Guerra Riccardo Calvani Riccardo Calvani Hélio José Coelho-Júnior Francesco Landi Francesco Landi Roberto Bernabei Roberto Bernabei Roberta Romano Cecilia Bucci Emanuele Marzetti Emanuele Marzetti Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease Frontiers in Immunology Alzheimer’s disease damage-associated molecular patterns endo-lysosomal system inflammation innate immunity mitochondrial-derived vesicles |
| title | Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease |
| title_full | Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease |
| title_fullStr | Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease |
| title_full_unstemmed | Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease |
| title_short | Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease |
| title_sort | extracellular vesicles and damage associated molecular patterns a pandora s box in health and disease |
| topic | Alzheimer’s disease damage-associated molecular patterns endo-lysosomal system inflammation innate immunity mitochondrial-derived vesicles |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.601740/full |
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