Study of siRNA Delivery via Polymeric Nanoparticles in Combination with Angiogenesis Inhibitor for The Treatment of <i>AFP</i>-Related Liver Cancer

Study of siRNA Delivery via Polymeric Nanoparticles in Combination with Angiogenesis Inhibitor for The Treatment of <i>AFP</i>-Related Liver Cancer

Angiogenesis inhibitor drugs have been explored as important pharmacological agents for cancer therapy, including hepatocellular carcinoma. These agents have several drawbacks, such as drug resistance, nonspecific toxicity, and systemic side effects. Therefore, combination therapy of the drug and sm...

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Bibliographic Details
Main Authors: Kittiporn Punuch, Chamaiphorn Wongwan, Saranrat Jantana, Chayapol Somboonyosdech, Kamonlatth Rodponthukwaji, Natsuda Kunwong, Kytai T. Nguyen, Vorapan Sirivatanauksorn, Yongyut Sirivatanauksorn, Chatchawan Srisawat, Primana Punnakitikashem
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
hepatocellular carcinoma (HCC)
alpha-fetoprotein (AFP)
small interfering RNA (siRNA)
angiogenesis inhibitor
nanoparticle (NP)
polylactic-co-glycolic acid (PLGA)
Online Access:https://www.mdpi.com/1422-0067/23/20/12666

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