Exploring the selective gray matter profile of autism spectrum disorder through Bayes Factor Modeling
Introduction Despite decades of brain MRI research demonstrating atypical neuroanatomical substrate in patients with autism spectrum disorder (ASD), it remains unclear whether and to what extent disorder-selective neuroanatomical abnormalities occur in this spectrum. This, and the fact that multipl...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S092493382201642X/type/journal_article |
| _version_ | 1797616129418461184 |
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| author | D. Liloia F. Cauda L. Uddin J. Manuello L. Mancuso R. Keller T. Costa |
| author_facet | D. Liloia F. Cauda L. Uddin J. Manuello L. Mancuso R. Keller T. Costa |
| author_sort | D. Liloia |
| collection | DOAJ |
| description |
Introduction
Despite decades of brain MRI research demonstrating atypical neuroanatomical substrate in patients with autism spectrum disorder (ASD), it remains unclear whether and to what extent disorder-selective neuroanatomical abnormalities occur in this spectrum. This, and the fact that multiple brain disorders report a common neuroanatomical substrate, makes transference and the application of neuroimaging findings into the clinical setting an open challenge.
Objectives
To investigate the selective neuroanatomical alteration profile of the ASD brain, we employed a meta-analytic, data-driven, and reverse inference-based approach (i.e.; Bayes fACtor mOdeliNg).
Methods
Eligible voxel-based morphometry data were extracted by a standardized search on BrainMap and MEDLINE databases (849 published experiments, 131 brain disorders, 22747 clinical subjects, 16572 x-y-z coordinates). Two distinct datasets were generated: the ASD dataset, composed of ASD-related data; and the non-ASD dataset, composed of all other clinical conditions data. Starting from the two unthresholded activation likelihood estimation (ALE) maps, the calculus of the Bayes fACtor mOdeliNg was performed. This allowed us to obtain posterior probability distributions on the evidence of brain alteration specificity in ASD.
Results
We revealed both cortical and cerebellar areas of neuroanatomical alteration selectivity in ASD. Eight clusters showed a selectivity value ≥ 90%, namely the bilateral precuneus, the right inferior occipital gyrus, left lobule IX, left Crus II, right Crus I, and the right lobule VIIIA (Fig. 1).
Conclusions
The identification of this neuroanatomical pattern provides new insights into the complex pathophysiology of ASD, opening attractive prospects for future neuroimaging-based interventions.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:36:53Z |
| format | Article |
| id | doaj.art-5b425ad2753f416882f5b6556d3425b0 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:36:53Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-5b425ad2753f416882f5b6556d3425b02023-11-17T05:09:19ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S640S64010.1192/j.eurpsy.2022.1642Exploring the selective gray matter profile of autism spectrum disorder through Bayes Factor ModelingD. Liloia0F. Cauda1L. Uddin2J. Manuello3L. Mancuso4R. Keller5T. Costa6University of Turin, Psychology, Turin, ItalyUniversity of Turin, Psychology, Turin, ItalyUniversity of California, Psychiatry And Biobehavioral Sciences, Los Angeles, United States of AmericaUniversity of Turin, Psychology, Turin, ItalyUniversity of Turin, Psychology, Turin, ItalyAdult Autism Centre, Asl To Unit, Torino, ItalyUniversity of Turin, Psychology, Turin, Italy Introduction Despite decades of brain MRI research demonstrating atypical neuroanatomical substrate in patients with autism spectrum disorder (ASD), it remains unclear whether and to what extent disorder-selective neuroanatomical abnormalities occur in this spectrum. This, and the fact that multiple brain disorders report a common neuroanatomical substrate, makes transference and the application of neuroimaging findings into the clinical setting an open challenge. Objectives To investigate the selective neuroanatomical alteration profile of the ASD brain, we employed a meta-analytic, data-driven, and reverse inference-based approach (i.e.; Bayes fACtor mOdeliNg). Methods Eligible voxel-based morphometry data were extracted by a standardized search on BrainMap and MEDLINE databases (849 published experiments, 131 brain disorders, 22747 clinical subjects, 16572 x-y-z coordinates). Two distinct datasets were generated: the ASD dataset, composed of ASD-related data; and the non-ASD dataset, composed of all other clinical conditions data. Starting from the two unthresholded activation likelihood estimation (ALE) maps, the calculus of the Bayes fACtor mOdeliNg was performed. This allowed us to obtain posterior probability distributions on the evidence of brain alteration specificity in ASD. Results We revealed both cortical and cerebellar areas of neuroanatomical alteration selectivity in ASD. Eight clusters showed a selectivity value ≥ 90%, namely the bilateral precuneus, the right inferior occipital gyrus, left lobule IX, left Crus II, right Crus I, and the right lobule VIIIA (Fig. 1). Conclusions The identification of this neuroanatomical pattern provides new insights into the complex pathophysiology of ASD, opening attractive prospects for future neuroimaging-based interventions. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S092493382201642X/type/journal_articlereverse inferencecerebellumdefault-mode networkstructural MRI |
| spellingShingle | D. Liloia F. Cauda L. Uddin J. Manuello L. Mancuso R. Keller T. Costa Exploring the selective gray matter profile of autism spectrum disorder through Bayes Factor Modeling European Psychiatry reverse inference cerebellum default-mode network structural MRI |
| title | Exploring the selective gray matter profile of autism spectrum disorder through Bayes Factor Modeling |
| title_full | Exploring the selective gray matter profile of autism spectrum disorder through Bayes Factor Modeling |
| title_fullStr | Exploring the selective gray matter profile of autism spectrum disorder through Bayes Factor Modeling |
| title_full_unstemmed | Exploring the selective gray matter profile of autism spectrum disorder through Bayes Factor Modeling |
| title_short | Exploring the selective gray matter profile of autism spectrum disorder through Bayes Factor Modeling |
| title_sort | exploring the selective gray matter profile of autism spectrum disorder through bayes factor modeling |
| topic | reverse inference cerebellum default-mode network structural MRI |
| url | https://www.cambridge.org/core/product/identifier/S092493382201642X/type/journal_article |
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