Dark Matter RNA: an Intelligent Scaffold for the Dynamic Regulation of the Nuclear Information Landscape
Perhaps no other topic in contemporary genomics has inspired such diverse viewpoints as the 95+% of the genome, previously known as junk DNA, that does not code for proteins. Here, we present a theory in which dark matter RNA plays a role in the generation of a landscape of spatial micro-domains cou...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-04-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00057/full |
| _version_ | 1818214247034781696 |
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| author | Georges eSt. Laurent Yiannis eSavva Philipp eKapranov |
| author_facet | Georges eSt. Laurent Yiannis eSavva Philipp eKapranov |
| author_sort | Georges eSt. Laurent |
| collection | DOAJ |
| description | Perhaps no other topic in contemporary genomics has inspired such diverse viewpoints as the 95+% of the genome, previously known as junk DNA, that does not code for proteins. Here, we present a theory in which dark matter RNA plays a role in the generation of a landscape of spatial micro-domains coupled to the information signaling matrix of the nuclear landscape. Within and between these microdomains, dark matter RNAs additionally function to tether RNA interacting proteins and complexes of many different types, and by doing so, allow for a higher performance of the various processes requiring them at ultra-fast rates. This improves signal to noise characteristics of RNA processing, trafficking, and epigenetic signaling, where competition and differential RNA binding among proteins drives the computational decisions inherent in regulatory events. |
| first_indexed | 2024-12-12T06:17:09Z |
| format | Article |
| id | doaj.art-5b42e3fcce5244d9b78f5618e5d1f95b |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-12T06:17:09Z |
| publishDate | 2012-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-5b42e3fcce5244d9b78f5618e5d1f95b2022-12-22T00:35:00ZengFrontiers Media S.A.Frontiers in Genetics1664-80212012-04-01310.3389/fgene.2012.0005724178Dark Matter RNA: an Intelligent Scaffold for the Dynamic Regulation of the Nuclear Information LandscapeGeorges eSt. Laurent0Yiannis eSavva1Philipp eKapranov2St. Laurent InstituteBrown UniversitySt. Laurent InstitutePerhaps no other topic in contemporary genomics has inspired such diverse viewpoints as the 95+% of the genome, previously known as junk DNA, that does not code for proteins. Here, we present a theory in which dark matter RNA plays a role in the generation of a landscape of spatial micro-domains coupled to the information signaling matrix of the nuclear landscape. Within and between these microdomains, dark matter RNAs additionally function to tether RNA interacting proteins and complexes of many different types, and by doing so, allow for a higher performance of the various processes requiring them at ultra-fast rates. This improves signal to noise characteristics of RNA processing, trafficking, and epigenetic signaling, where competition and differential RNA binding among proteins drives the computational decisions inherent in regulatory events.http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00057/fullRNA Editingnon-coding RNARNA binding proteinRNA processingbiological signalingdark matter RNA |
| spellingShingle | Georges eSt. Laurent Yiannis eSavva Philipp eKapranov Dark Matter RNA: an Intelligent Scaffold for the Dynamic Regulation of the Nuclear Information Landscape Frontiers in Genetics RNA Editing non-coding RNA RNA binding protein RNA processing biological signaling dark matter RNA |
| title | Dark Matter RNA: an Intelligent Scaffold for the Dynamic Regulation of the Nuclear Information Landscape |
| title_full | Dark Matter RNA: an Intelligent Scaffold for the Dynamic Regulation of the Nuclear Information Landscape |
| title_fullStr | Dark Matter RNA: an Intelligent Scaffold for the Dynamic Regulation of the Nuclear Information Landscape |
| title_full_unstemmed | Dark Matter RNA: an Intelligent Scaffold for the Dynamic Regulation of the Nuclear Information Landscape |
| title_short | Dark Matter RNA: an Intelligent Scaffold for the Dynamic Regulation of the Nuclear Information Landscape |
| title_sort | dark matter rna an intelligent scaffold for the dynamic regulation of the nuclear information landscape |
| topic | RNA Editing non-coding RNA RNA binding protein RNA processing biological signaling dark matter RNA |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00057/full |
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