Effects of <i>Spirulina maxima</i> on a Model of Sexual Dysfunction in Streptozotocin-Induced Diabetic Male Rats
<i>Arthrospira (Spirulina) maxima</i> (SM) is a cyanobacterium that has a long history of being used as human food. In recent years, several investigations have shown its beneficial biological effects, among which its antioxidant capacity has been highlighted. The purpose of this study w...
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MDPI AG
2023-02-01
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| Online Access: | https://www.mdpi.com/2223-7747/12/4/722 |
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| author | Eduardo Osel Olvera-Roldán José Melesio Cristóbal-Luna Yuliana García-Martínez María Angélica Mojica-Villegas Ricardo Pérez-Pastén-Borja Gabriela Gutiérrez-Salmeán Salud Pérez-Gutiérrez Rosa Virginia García-Rodríguez Eduardo Madrigal-Santillán José A. Morales-González Germán Chamorro-Cevallos |
| author_facet | Eduardo Osel Olvera-Roldán José Melesio Cristóbal-Luna Yuliana García-Martínez María Angélica Mojica-Villegas Ricardo Pérez-Pastén-Borja Gabriela Gutiérrez-Salmeán Salud Pérez-Gutiérrez Rosa Virginia García-Rodríguez Eduardo Madrigal-Santillán José A. Morales-González Germán Chamorro-Cevallos |
| author_sort | Eduardo Osel Olvera-Roldán |
| collection | DOAJ |
| description | <i>Arthrospira (Spirulina) maxima</i> (SM) is a cyanobacterium that has a long history of being used as human food. In recent years, several investigations have shown its beneficial biological effects, among which its antioxidant capacity has been highlighted. The purpose of this study was to evaluate the effects of SM on body weight, glycemia, sexual behavior, sperm quality, testosterone levels, sex organ weights, and the activity of antioxidant enzymes in diabetic male rats (a disease characterized by an increase in reactive oxygen species). The experiment consisted of six groups of sexually expert adult males (n = 6): (1) control (vehicle); (2) streptozotocin (STZ)-65 mg/kg; (3) SM-400 mg/kg; (4) STZ + SM-100 mg/kg; (5) STZ + SM-200 mg/kg; and (6) STZ + SM-400 mg/kg. Sexual behavior tests were performed during the first 3 h of the dark period under dim red illumination. Our results showed that SM significantly improved sexual behavior and sperm quality vs. diabetic animals. Likewise, while the enzymatic activities of SOD and GPx increased, TBARS lipoperoxidation decreased and testosterone levels increased. In view of the findings, it is suggested that SM may potentially be used as a nutraceutical for the treatment of diabetic male sexual dysfunction due to its antioxidant property. |
| first_indexed | 2024-03-11T08:15:44Z |
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| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-11T08:15:44Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-5b442e32dd1c4aa59050248b2f09455c2023-11-16T22:46:35ZengMDPI AGPlants2223-77472023-02-0112472210.3390/plants12040722Effects of <i>Spirulina maxima</i> on a Model of Sexual Dysfunction in Streptozotocin-Induced Diabetic Male RatsEduardo Osel Olvera-Roldán0José Melesio Cristóbal-Luna1Yuliana García-Martínez2María Angélica Mojica-Villegas3Ricardo Pérez-Pastén-Borja4Gabriela Gutiérrez-Salmeán5Salud Pérez-Gutiérrez6Rosa Virginia García-Rodríguez7Eduardo Madrigal-Santillán8José A. Morales-González9Germán Chamorro-Cevallos10Laboratorio de Toxicología Preclínica, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City C.P. 07738, MexicoLaboratorio de Toxicología Preclínica, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City C.P. 07738, MexicoLaboratorio de Toxicología Preclínica, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City C.P. 07738, MexicoLaboratorio de Toxicología Preclínica, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City C.P. 07738, MexicoLaboratorio de Toxicología Preclínica, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City C.P. 07738, MexicoFacultad de Ciencias de la Salud/Centro de Investigaciones en Ciencias de la Salud (CICSA), Universidad Anáhuac, Mexico City C.P. 52786, MexicoDepartamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Mexico City C.P. 04960, MexicoUnidad de Servicios de Apoyo en Resolución Analítica, Universidad Veracruzana, Xalapa C.P. 91190, MexicoLaboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City C.P. 11340, MexicoLaboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City C.P. 11340, MexicoLaboratorio de Toxicología Preclínica, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City C.P. 07738, Mexico<i>Arthrospira (Spirulina) maxima</i> (SM) is a cyanobacterium that has a long history of being used as human food. In recent years, several investigations have shown its beneficial biological effects, among which its antioxidant capacity has been highlighted. The purpose of this study was to evaluate the effects of SM on body weight, glycemia, sexual behavior, sperm quality, testosterone levels, sex organ weights, and the activity of antioxidant enzymes in diabetic male rats (a disease characterized by an increase in reactive oxygen species). The experiment consisted of six groups of sexually expert adult males (n = 6): (1) control (vehicle); (2) streptozotocin (STZ)-65 mg/kg; (3) SM-400 mg/kg; (4) STZ + SM-100 mg/kg; (5) STZ + SM-200 mg/kg; and (6) STZ + SM-400 mg/kg. Sexual behavior tests were performed during the first 3 h of the dark period under dim red illumination. Our results showed that SM significantly improved sexual behavior and sperm quality vs. diabetic animals. Likewise, while the enzymatic activities of SOD and GPx increased, TBARS lipoperoxidation decreased and testosterone levels increased. In view of the findings, it is suggested that SM may potentially be used as a nutraceutical for the treatment of diabetic male sexual dysfunction due to its antioxidant property.https://www.mdpi.com/2223-7747/12/4/722diabetes mellitussexual behavioroxidative stress<i>Spirulina maxima</i> |
| spellingShingle | Eduardo Osel Olvera-Roldán José Melesio Cristóbal-Luna Yuliana García-Martínez María Angélica Mojica-Villegas Ricardo Pérez-Pastén-Borja Gabriela Gutiérrez-Salmeán Salud Pérez-Gutiérrez Rosa Virginia García-Rodríguez Eduardo Madrigal-Santillán José A. Morales-González Germán Chamorro-Cevallos Effects of <i>Spirulina maxima</i> on a Model of Sexual Dysfunction in Streptozotocin-Induced Diabetic Male Rats Plants diabetes mellitus sexual behavior oxidative stress <i>Spirulina maxima</i> |
| title | Effects of <i>Spirulina maxima</i> on a Model of Sexual Dysfunction in Streptozotocin-Induced Diabetic Male Rats |
| title_full | Effects of <i>Spirulina maxima</i> on a Model of Sexual Dysfunction in Streptozotocin-Induced Diabetic Male Rats |
| title_fullStr | Effects of <i>Spirulina maxima</i> on a Model of Sexual Dysfunction in Streptozotocin-Induced Diabetic Male Rats |
| title_full_unstemmed | Effects of <i>Spirulina maxima</i> on a Model of Sexual Dysfunction in Streptozotocin-Induced Diabetic Male Rats |
| title_short | Effects of <i>Spirulina maxima</i> on a Model of Sexual Dysfunction in Streptozotocin-Induced Diabetic Male Rats |
| title_sort | effects of i spirulina maxima i on a model of sexual dysfunction in streptozotocin induced diabetic male rats |
| topic | diabetes mellitus sexual behavior oxidative stress <i>Spirulina maxima</i> |
| url | https://www.mdpi.com/2223-7747/12/4/722 |
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