Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor.

Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor.

The use of targeted therapeutics to replenish pathologically deficient proteins on the luminal endothelial membrane has the potential to revolutionize emergency and cardiovascular medicine. Untargeted recombinant proteins, like activated protein C (APC) and thrombomodulin (TM), have demonstrated ben...

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Bibliographic Details
Main Authors: Colin F Greineder, Ann-Marie Chacko, Sergei Zaytsev, Blaine J Zern, Ronald Carnemolla, Elizabeth D Hood, Jingyan Han, Bi-Sen Ding, Charles T Esmon, Vladimir R Muzykantov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3828233?pdf=render

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