Autoimmune/inflammatory syndrome induced by adjuvants in a woman with Hashimoto thyroiditis and familial autoimmunity—a case report and literature review
IntroductionAutoimmune/inflammatory syndrome induced by adjuvants (ASIA) consists of a wide spectrum of symptoms and immunological features that are believed to develop in predisposed individuals after exposure to an adjuvant, including a silicone breast implant (SBI). Different autoimmune diseases...
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139603/full |
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| author | Aleksandra Plavsic Aleksandra Plavsic Snezana Arandjelovic Snezana Arandjelovic Milan Dimitrijevic Natasa Kusic Vesna Tomic Spiric Vesna Tomic Spiric Bojana Popovic Bojana Popovic Zikica Jovicic Zikica Jovicic Aleksandra Peric Popadic Aleksandra Peric Popadic Rada Miskovic Rada Miskovic |
| author_facet | Aleksandra Plavsic Aleksandra Plavsic Snezana Arandjelovic Snezana Arandjelovic Milan Dimitrijevic Natasa Kusic Vesna Tomic Spiric Vesna Tomic Spiric Bojana Popovic Bojana Popovic Zikica Jovicic Zikica Jovicic Aleksandra Peric Popadic Aleksandra Peric Popadic Rada Miskovic Rada Miskovic |
| author_sort | Aleksandra Plavsic |
| collection | DOAJ |
| description | IntroductionAutoimmune/inflammatory syndrome induced by adjuvants (ASIA) consists of a wide spectrum of symptoms and immunological features that are believed to develop in predisposed individuals after exposure to an adjuvant, including a silicone breast implant (SBI). Different autoimmune diseases (AIDs) have been associated with ASIA, but ASIA development after SBI in women with Hashimoto thyroiditis (HT) and familial autoimmunity has rarely been described.Case reportA 37-year-old woman presented in 2019 with arthralgia, sicca symptoms, fatigue, + antinuclear antibody (ANA), + anti SSA, and + anticardiolipin Immunoglobulin G (IgG) antibodies. She was diagnosed with HT and vitamin D deficiency in 2012. The familial autoimmunity was present: the patient’s mother had been diagnosed with systemic lupus erythematosus and secondary Sjogren’s syndrome and her grandmother with cutaneous lupus and pernicious anemia. In 2017, the patient had a cosmetic SBI procedure that was complicated by repeated right breast capsulitis. After 2 years of irregular visits due to COVID-19, she presented with + ANA, + anticentromere antibodies both in sera and seroma, sicca syndrome, arthralgias, twinkling in extremities, abnormal capillaroscopic findings, and reduced diffusing capacity of the lungs for carbon monoxide. She was diagnosed with ASIA, and antimalarial and corticosteroid therapy were introduced.ConclusionIn patients with HT and familial autoimmunity, SBI should be carefully considered due to the possibility of ASIA development. Hashimoto thyroiditis, familial autoimmunity, and ASIA seem to be interconnected in the complex mosaic of autoimmunity in predisposed individuals. |
| first_indexed | 2024-03-13T10:02:08Z |
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| id | doaj.art-5b4764f60a444f8c83e0c4475ca5c0c5 |
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| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T10:02:08Z |
| publishDate | 2023-05-01 |
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| series | Frontiers in Immunology |
| spelling | doaj.art-5b4764f60a444f8c83e0c4475ca5c0c52023-05-23T05:07:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11396031139603Autoimmune/inflammatory syndrome induced by adjuvants in a woman with Hashimoto thyroiditis and familial autoimmunity—a case report and literature reviewAleksandra Plavsic0Aleksandra Plavsic1Snezana Arandjelovic2Snezana Arandjelovic3Milan Dimitrijevic4Natasa Kusic5Vesna Tomic Spiric6Vesna Tomic Spiric7Bojana Popovic8Bojana Popovic9Zikica Jovicic10Zikica Jovicic11Aleksandra Peric Popadic12Aleksandra Peric Popadic13Rada Miskovic14Rada Miskovic15Clinic for Allergy and Immunology, University Clinical Centre of Serbia, Belgrade, SerbiaFaculty of Medicine, University Clinical Centre of Serbia, Belgrade, SerbiaClinic for Allergy and Immunology, University Clinical Centre of Serbia, Belgrade, SerbiaFaculty of Medicine, University Clinical Centre of Serbia, Belgrade, SerbiaClinic for Allergy and Immunology, University Clinical Centre of Serbia, Belgrade, SerbiaClinic for Allergy and Immunology, University Clinical Centre of Serbia, Belgrade, SerbiaClinic for Allergy and Immunology, University Clinical Centre of Serbia, Belgrade, SerbiaClinic for Endocrinology, Diabetes, and Metabolic Diseases, University Clinical Centre of Serbia, Belgrade, SerbiaFaculty of Medicine, University Clinical Centre of Serbia, Belgrade, SerbiaClinic for Endocrinology, Diabetes, and Metabolic Diseases, University Clinical Centre of Serbia, Belgrade, SerbiaClinic for Allergy and Immunology, University Clinical Centre of Serbia, Belgrade, SerbiaFaculty of Medicine, University Clinical Centre of Serbia, Belgrade, SerbiaClinic for Allergy and Immunology, University Clinical Centre of Serbia, Belgrade, SerbiaFaculty of Medicine, University Clinical Centre of Serbia, Belgrade, SerbiaClinic for Allergy and Immunology, University Clinical Centre of Serbia, Belgrade, SerbiaFaculty of Medicine, University Clinical Centre of Serbia, Belgrade, SerbiaIntroductionAutoimmune/inflammatory syndrome induced by adjuvants (ASIA) consists of a wide spectrum of symptoms and immunological features that are believed to develop in predisposed individuals after exposure to an adjuvant, including a silicone breast implant (SBI). Different autoimmune diseases (AIDs) have been associated with ASIA, but ASIA development after SBI in women with Hashimoto thyroiditis (HT) and familial autoimmunity has rarely been described.Case reportA 37-year-old woman presented in 2019 with arthralgia, sicca symptoms, fatigue, + antinuclear antibody (ANA), + anti SSA, and + anticardiolipin Immunoglobulin G (IgG) antibodies. She was diagnosed with HT and vitamin D deficiency in 2012. The familial autoimmunity was present: the patient’s mother had been diagnosed with systemic lupus erythematosus and secondary Sjogren’s syndrome and her grandmother with cutaneous lupus and pernicious anemia. In 2017, the patient had a cosmetic SBI procedure that was complicated by repeated right breast capsulitis. After 2 years of irregular visits due to COVID-19, she presented with + ANA, + anticentromere antibodies both in sera and seroma, sicca syndrome, arthralgias, twinkling in extremities, abnormal capillaroscopic findings, and reduced diffusing capacity of the lungs for carbon monoxide. She was diagnosed with ASIA, and antimalarial and corticosteroid therapy were introduced.ConclusionIn patients with HT and familial autoimmunity, SBI should be carefully considered due to the possibility of ASIA development. Hashimoto thyroiditis, familial autoimmunity, and ASIA seem to be interconnected in the complex mosaic of autoimmunity in predisposed individuals.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139603/fullASIAHashimoto thyroiditisfamilial autoimmunityAIDSBI |
| spellingShingle | Aleksandra Plavsic Aleksandra Plavsic Snezana Arandjelovic Snezana Arandjelovic Milan Dimitrijevic Natasa Kusic Vesna Tomic Spiric Vesna Tomic Spiric Bojana Popovic Bojana Popovic Zikica Jovicic Zikica Jovicic Aleksandra Peric Popadic Aleksandra Peric Popadic Rada Miskovic Rada Miskovic Autoimmune/inflammatory syndrome induced by adjuvants in a woman with Hashimoto thyroiditis and familial autoimmunity—a case report and literature review Frontiers in Immunology ASIA Hashimoto thyroiditis familial autoimmunity AID SBI |
| title | Autoimmune/inflammatory syndrome induced by adjuvants in a woman with Hashimoto thyroiditis and familial autoimmunity—a case report and literature review |
| title_full | Autoimmune/inflammatory syndrome induced by adjuvants in a woman with Hashimoto thyroiditis and familial autoimmunity—a case report and literature review |
| title_fullStr | Autoimmune/inflammatory syndrome induced by adjuvants in a woman with Hashimoto thyroiditis and familial autoimmunity—a case report and literature review |
| title_full_unstemmed | Autoimmune/inflammatory syndrome induced by adjuvants in a woman with Hashimoto thyroiditis and familial autoimmunity—a case report and literature review |
| title_short | Autoimmune/inflammatory syndrome induced by adjuvants in a woman with Hashimoto thyroiditis and familial autoimmunity—a case report and literature review |
| title_sort | autoimmune inflammatory syndrome induced by adjuvants in a woman with hashimoto thyroiditis and familial autoimmunity a case report and literature review |
| topic | ASIA Hashimoto thyroiditis familial autoimmunity AID SBI |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139603/full |
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