A novel site comes into sight
Oxysterols modulate the Hedgehog signalling pathway by binding a novel site on the membrane protein Smoothened, which may offer new options for the treatment of cancers linked to this pathway.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2013-12-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/01680 |
| _version_ | 1811200105332604928 |
|---|---|
| author | Yu Wang Andrew P McMahon |
| author_facet | Yu Wang Andrew P McMahon |
| author_sort | Yu Wang |
| collection | DOAJ |
| description | Oxysterols modulate the Hedgehog signalling pathway by binding a novel site on the membrane protein Smoothened, which may offer new options for the treatment of cancers linked to this pathway. |
| first_indexed | 2024-04-12T01:59:10Z |
| format | Article |
| id | doaj.art-5b492ff0c16847f1924b9a21b61e53ef |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:59:10Z |
| publishDate | 2013-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-5b492ff0c16847f1924b9a21b61e53ef2022-12-22T03:52:43ZengeLife Sciences Publications LtdeLife2050-084X2013-12-01210.7554/eLife.01680A novel site comes into sightYu Wang0Andrew P McMahon1State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad-California Institute for Regenerative Medicine Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine of the University of Southern California, Los Angeles, United StatesOxysterols modulate the Hedgehog signalling pathway by binding a novel site on the membrane protein Smoothened, which may offer new options for the treatment of cancers linked to this pathway.https://elifesciences.org/articles/01680Hedgehog signalingoxysterolsmoothenedcysteine rich domain |
| spellingShingle | Yu Wang Andrew P McMahon A novel site comes into sight eLife Hedgehog signaling oxysterol smoothened cysteine rich domain |
| title | A novel site comes into sight |
| title_full | A novel site comes into sight |
| title_fullStr | A novel site comes into sight |
| title_full_unstemmed | A novel site comes into sight |
| title_short | A novel site comes into sight |
| title_sort | novel site comes into sight |
| topic | Hedgehog signaling oxysterol smoothened cysteine rich domain |
| url | https://elifesciences.org/articles/01680 |
| work_keys_str_mv | AT yuwang anovelsitecomesintosight AT andrewpmcmahon anovelsitecomesintosight AT yuwang novelsitecomesintosight AT andrewpmcmahon novelsitecomesintosight |