FGF7–FGFR2 autocrine signaling increases growth and chemoresistance of fusion‐positive rhabdomyosarcomas

FGF7–FGFR2 autocrine signaling increases growth and chemoresistance of fusion‐positive rhabdomyosarcomas

Rhabdomyosarcomas are aggressive pediatric soft‐tissue sarcomas and include high‐risk PAX3–FOXO1 fusion‐gene‐positive cases. Fibroblast growth factor receptor 4 (FGFR4) is known to contribute to rhabdomyosarcoma progression; here, we sought to investigate the involvement and potential for therapeuti...

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Bibliographic Details
Main Authors: Christopher I. Milton, Joanna Selfe, Ewa Aladowicz, Stella Y. K. Man, Carolina Bernauer, Edoardo Missiaglia, Zoë S. Walters, Susanne A. Gatz, Anna Kelsey, Melanie Generali, Gary Box, Melanie Valenti, Alexis deHaven‐Brandon, David Galiwango, Angela Hayes, Matthew Clarke, Elisa Izquierdo, David Gonzalez De Castro, Florence I. Raynaud, Vladimir Kirkin, Janet M. Shipley
Format: Article
Language:English
Published: Wiley 2022-03-01
Series:Molecular Oncology
Subjects:
autocrine loop
FGF7
FGFR2
fibroblast growth factor receptor
NVP‐BGJ398
rhabdomyosarcoma
Online Access:https://doi.org/10.1002/1878-0261.13145

Internet

https://doi.org/10.1002/1878-0261.13145

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