Activation of adiponectin receptors has negative impact on muscle mass in C2C12 myotubes and fast-type mouse skeletal muscle.

Activation of adiponectin receptors has negative impact on muscle mass in C2C12 myotubes and fast-type mouse skeletal muscle.

This study investigated the effects of AdipoRon, which is an agonist for adiponectin receptor 1 (AdipoR1) and AdipoR2, on the protein content, myotube diameter, and number of nuclei per myotube of C2C12 cells and skeletal muscle mass in C57BL/6J mice. AdipoRon suppressed the protein content, myotube...

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Bibliographic Details
Main Authors: Rika Ito, Masaki Higa, Ayumi Goto, Megumi Aoshima, Akihiro Ikuta, Kazuya Ohashi, Shingo Yokoyama, Yoshitaka Ohno, Tatsuro Egawa, Hirofumi Miyata, Katsumasa Goto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6181411?pdf=render

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