Toxicity Analysis of Mesoporous Polydopamine on Intestinal Tissue and Microflora
As a promising therapy, photothermal therapy (PTT) converts near-infrared (NIR) light into heat through efficient photothermal agents (PTAs), causing a rapid increase in local temperature. Considering the importance of PTAs in the clinical application of PTT, the safety of PTAs should be carefully e...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/19/6461 |
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| author | Luoyijun Xie Qiyan Li Yingying Liao Zihua Huang Yulin Liu Chutong Liu Leilei Shi Qingjiao Li Miaomiao Yuan |
| author_facet | Luoyijun Xie Qiyan Li Yingying Liao Zihua Huang Yulin Liu Chutong Liu Leilei Shi Qingjiao Li Miaomiao Yuan |
| author_sort | Luoyijun Xie |
| collection | DOAJ |
| description | As a promising therapy, photothermal therapy (PTT) converts near-infrared (NIR) light into heat through efficient photothermal agents (PTAs), causing a rapid increase in local temperature. Considering the importance of PTAs in the clinical application of PTT, the safety of PTAs should be carefully evaluated before their widespread use. As a promising PTA, mesoporous polydopamine (MPDA) was studied for its clinical applications for tumor photothermal therapy and drug delivery. Given the important role that intestinal microflora plays in health, the impacts of MPDA on the intestine and on intestinal microflora were systematically evaluated in this study. Through biological and animal experiments, it was found that MPDA exhibited excellent biocompatibility, in vitro and in vivo. Moreover, 16S rRNA analysis demonstrated that there was no obvious difference in the composition and classification of intestinal microflora between different drug delivery groups and the control group. The results provided new evidence that MPDA was safe to use in large doses via different drug delivery means, and this lays the foundation for further clinical applications. |
| first_indexed | 2024-03-09T21:24:36Z |
| format | Article |
| id | doaj.art-5b4b244c27a24ecfaff7423430d47691 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T21:24:36Z |
| publishDate | 2022-09-01 |
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| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5b4b244c27a24ecfaff7423430d476912023-11-23T21:11:47ZengMDPI AGMolecules1420-30492022-09-012719646110.3390/molecules27196461Toxicity Analysis of Mesoporous Polydopamine on Intestinal Tissue and MicrofloraLuoyijun Xie0Qiyan Li1Yingying Liao2Zihua Huang3Yulin Liu4Chutong Liu5Leilei Shi6Qingjiao Li7Miaomiao Yuan8The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518017, ChinaThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518017, ChinaThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518017, ChinaThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518017, ChinaThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518017, ChinaThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518017, ChinaThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518017, ChinaThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518017, ChinaThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518017, ChinaAs a promising therapy, photothermal therapy (PTT) converts near-infrared (NIR) light into heat through efficient photothermal agents (PTAs), causing a rapid increase in local temperature. Considering the importance of PTAs in the clinical application of PTT, the safety of PTAs should be carefully evaluated before their widespread use. As a promising PTA, mesoporous polydopamine (MPDA) was studied for its clinical applications for tumor photothermal therapy and drug delivery. Given the important role that intestinal microflora plays in health, the impacts of MPDA on the intestine and on intestinal microflora were systematically evaluated in this study. Through biological and animal experiments, it was found that MPDA exhibited excellent biocompatibility, in vitro and in vivo. Moreover, 16S rRNA analysis demonstrated that there was no obvious difference in the composition and classification of intestinal microflora between different drug delivery groups and the control group. The results provided new evidence that MPDA was safe to use in large doses via different drug delivery means, and this lays the foundation for further clinical applications.https://www.mdpi.com/1420-3049/27/19/6461intestinal microfloramesoporous polydopaminetoxicity analysis16S rRNA gene sequencing |
| spellingShingle | Luoyijun Xie Qiyan Li Yingying Liao Zihua Huang Yulin Liu Chutong Liu Leilei Shi Qingjiao Li Miaomiao Yuan Toxicity Analysis of Mesoporous Polydopamine on Intestinal Tissue and Microflora Molecules intestinal microflora mesoporous polydopamine toxicity analysis 16S rRNA gene sequencing |
| title | Toxicity Analysis of Mesoporous Polydopamine on Intestinal Tissue and Microflora |
| title_full | Toxicity Analysis of Mesoporous Polydopamine on Intestinal Tissue and Microflora |
| title_fullStr | Toxicity Analysis of Mesoporous Polydopamine on Intestinal Tissue and Microflora |
| title_full_unstemmed | Toxicity Analysis of Mesoporous Polydopamine on Intestinal Tissue and Microflora |
| title_short | Toxicity Analysis of Mesoporous Polydopamine on Intestinal Tissue and Microflora |
| title_sort | toxicity analysis of mesoporous polydopamine on intestinal tissue and microflora |
| topic | intestinal microflora mesoporous polydopamine toxicity analysis 16S rRNA gene sequencing |
| url | https://www.mdpi.com/1420-3049/27/19/6461 |
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